The neuroimmune model of excessive alcohol consumption: Transition to Alcohol Use Disorder.

过量饮酒的神经免疫模型:向酒精使用障碍的转变。

基本信息

项目摘要

Project Summary/Abstract Activation of the innate immune system results in the release of pro-inflammatory cytokines, which may lead to changes in neuroimmune signaling and behavioral abnormalities, such as high alcohol (ethanol) consumption, which may ultimately lead to the development of alcohol use disorder (AUD). We lack understanding of how changes in neuroimmune signaling are integrated into neuronal networks that mediate the transition from normal (social) drinking to excessive alcohol consumption. Here, we propose the neuroimmune model of excessive alcohol consumption, where repeated injections of the immune activator Poly(I:C) produce progressive escalation of alcohol intake over several weeks of drinking. We hypothesize that immune activation induces cell type-specific changes in gene expression, which are integrated to affect neuronal functions and drive excessive drinking. We will use a combination of molecular, cellular, behavioral and computational approaches to test this hypothesis. Gene expression will be measured in neurons, astrocytes and microglia to investigate cell type-specific molecular mechanisms of immune activation. We will then use molecular signatures from different cell types and computationally-driven drug-repurposing approaches to identify and test pharmacological compounds with the potential to reduce high alcohol drinking. We will investigate roles of specific neural networks in immune-induced escalation of drinking by measuring neuronal functions and manipulating excitability of critical projection neurons. Temporal profiling across three critical time points will identify dynamic changes in cell type-specific transcriptomes and neuronal functions. Results of the proposed experiments will advance our understanding of the role of neuroimmune signaling in the transition to AUD and will be widely applicable to brain disorders with pro- inflammatory phenotypes.
项目总结/文摘

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Igor Ponomarev其他文献

Igor Ponomarev的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Igor Ponomarev', 18)}}的其他基金

The neuroimmune model of excessive alcohol consumption: Transition to Alcohol Use Disorder.
过量饮酒的神经免疫模型:向酒精使用障碍的转变。
  • 批准号:
    9892345
  • 财政年份:
    2018
  • 资助金额:
    $ 57.38万
  • 项目类别:
The neuroimmune model of excessive alcohol consumption: Transition to Alcohol Use Disorder.
过量饮酒的神经免疫模型:向酒精使用障碍的转变。
  • 批准号:
    10200611
  • 财政年份:
    2018
  • 资助金额:
    $ 57.38万
  • 项目类别:
The neuroimmune model of excessive alcohol consumption: Transition to Alcohol Use Disorder.
过量饮酒的神经免疫模型:向酒精使用障碍的转变。
  • 批准号:
    9778698
  • 财政年份:
    2018
  • 资助金额:
    $ 57.38万
  • 项目类别:
Epigenetic control of gene expression in alcoholic brain
酗酒者大脑基因表达的表观遗传控制
  • 批准号:
    8511961
  • 财政年份:
    2013
  • 资助金额:
    $ 57.38万
  • 项目类别:
Epigenetic control of gene expression in alcoholic brain
酗酒者大脑基因表达的表观遗传控制
  • 批准号:
    8728702
  • 财政年份:
    2013
  • 资助金额:
    $ 57.38万
  • 项目类别:
Molecular and cellular mechanisms of novel targets in alcohol reward
酒精奖励新靶点的分子和细胞机制
  • 批准号:
    8201635
  • 财政年份:
    2012
  • 资助金额:
    $ 57.38万
  • 项目类别:
Molecular Mechanisms of Cellular Plasticity in a Mouse Model of Excessive Alcohol
过量饮酒小鼠模型细胞可塑性的分子机制
  • 批准号:
    8019762
  • 财政年份:
    2010
  • 资助金额:
    $ 57.38万
  • 项目类别:
Molecular Mechanisms of Cellular Plasticity in a Mouse Model of Excessive Alcohol
过量饮酒小鼠模型细胞可塑性的分子机制
  • 批准号:
    7357591
  • 财政年份:
    2008
  • 资助金额:
    $ 57.38万
  • 项目类别:
Molecular Mechanisms of Cellular Plasticity in a Mouse Model of Excessive Alcohol
过量饮酒小鼠模型细胞可塑性的分子机制
  • 批准号:
    7646436
  • 财政年份:
    2008
  • 资助金额:
    $ 57.38万
  • 项目类别:
Molecular Mechanisms of Cellular Plasticity in a Mouse Model of Excessive Alcohol
过量饮酒小鼠模型细胞可塑性的分子机制
  • 批准号:
    7877997
  • 财政年份:
    2008
  • 资助金额:
    $ 57.38万
  • 项目类别:

相似海外基金

How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 57.38万
  • 项目类别:
    Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 57.38万
  • 项目类别:
    Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 57.38万
  • 项目类别:
    Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 57.38万
  • 项目类别:
    Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 57.38万
  • 项目类别:
    Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 57.38万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 57.38万
  • 项目类别:
    Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 57.38万
  • 项目类别:
    Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
  • 批准号:
    23K00129
  • 财政年份:
    2023
  • 资助金额:
    $ 57.38万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
  • 批准号:
    2883985
  • 财政年份:
    2023
  • 资助金额:
    $ 57.38万
  • 项目类别:
    Studentship
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了