Subjective Valuation of Physical Effort in Health and Disease

健康和疾病中体力消耗的主观评价

• 批准号: 10437627
• 负责人: Vikram S Chib
• 金额: $ 39.7万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10437627
• 关键词: Behavioral; Behavioral Mechanisms; Brain; Brain region; Cognitive; Computer Models; Data; Decision Making; Disease; Exercise; Exertion; Exhibits; Fatigue; Feeling; Functional Magnetic Resonance Imaging; Goals; Health; Health Services Accessibility; Human; Individual; Intervention; Investigation; Judgment; Lead; Life; Light; Mathematics; Measures; Mediating; Mind; Motor; Motor Cortex; Motor output; Movement; Multiple Sclerosis; Nervous system structure; Neurologic; Outcome; Participant; Pathologic; Patient Self-Report; Patients; Physical Efforts; Physical Exercise; Physical activity; Physical therapy exercises; Physiological; Physiology; Property; Questionnaires; Rehabilitation therapy; Rewards; Scanning; Symptoms; Testing; Transcranial magnetic stimulation; Work; base; computer framework; cost; design; disabling symptom; experimental study; motor control; multiple sclerosis patient; neural circuit; neurobehavioral; neuromechanism; neuroregulation; non-compliance; noninvasive brain stimulation; novel; preference; prospective; relating to nervous system; social factors; transportation access; willingness

PROJECT SUMMARY A major hurdle to compliance with rehabilitation therapies is poor effort on the part of patients, caused by fatigue and feelings of insurmountable effort. If a physical exercise feels very effortful one may be unwilling to exert the effort required, whereas if an exercise feels less effortful one may be more likely to persevere. Despite the ubiquity of effort-based judgments, and their disruption in a variety of neurological conditions, the mechanisms responsible for the subjective valuation of physical effort have received limited investigation. The central hypothesis of this proposal is that an individual's subjective valuation of effort is reflected in her inherent excitability of motor cortex, and that this metric is sensitive to disease state. We will perform experiments in healthy human participants; and a group of participants with multiple sclerosis (MS). We have developed a novel effort-based choice paradigm that allows us to obtain a precise objective measure of an individual's subjective valuation of effort. We will use this approach, in combination with computational modeling, functional magnetic resonance imaging (fMRI), and noninvasive brain stimulation, to investigate the mechanisms responsible for the subjective valuation of effort. In Aim 1 we will study how motor physiology influences subjective effort valuation in healthy participants. We will use transcranial magnetic stimulation (TMS) to non invasively probe the physiological properties of participants' motor cortex; and we will have the same participants make decisions about effort while they are scanned with fMRI, and use this data to computationally model their subjective valuation of effort and associated brain activity. These experiments will allow us to test the relationships between an individual's representations of effort value and motor physiology. In Aim 2 we will identify the mechanisms of subjective effort valuation in patients with MS. We will use TMS and fMRI to investigate the neural and behavioral representations of effort value in MS. These experiments will shed light on the neural circuits that are disrupted in individuals with MS, suffering from feelings of fatigue. Our studies will have a broad impact on the fields of decision-making and motor control by dissecting the fundamental mechanisms responsible for physical effort valuation. This work will provide an understanding of the neural mechanisms underlying disrupted feelings of effort in MS, and may eventually reveal neurobehavioral markers and neuromodulatory interventions to aid in the prediction and treatment of rehabilitation non-compliance.

项目概要 遵守康复治疗的一个主要障碍是患者的努力不足，这是由以下原因造成的： 疲劳和难以克服的努力的感觉。如果一项体育锻炼感觉非常费力，人们可能不愿意 付出所需的努力，而如果一项运动感觉不那么费力，人们可能更有可能坚持下去。 尽管基于努力的判断无处不在，并且它们在各种神经系统疾病中受到干扰， 负责对体力努力进行主观评估的机制受到的调查有限。这 该提议的中心假设是，个人对努力的主观评价反映在她固有的 运动皮层的兴奋性，并且该指标对疾病状态敏感。我们将进行实验 健康的人类参与者；以及一组患有多发性硬化症（MS）的参与者。我们开发了一个 新颖的基于努力的选择范式，使我们能够准确客观地衡量个人的 对努力的主观评价。我们将使用这种方法，结合计算建模、功能 磁共振成像（fMRI）和无创脑刺激，以研究其机制 负责对努力的主观评估。在目标 1 中，我们将研究运动生理学如何影响 健康参与者的主观努力评估。我们将使用经颅磁刺激（TMS）来非 侵入性地探测参与者运动皮层的生理特性；我们也会有同样的 参与者在使用功能磁共振成像扫描时做出关于努力的决定，并使用这些数据进行计算 模拟他们对努力和相关大脑活动的主观评价。这些实验将使我们能够测试 个人对努力价值的表征与运动生理学之间的关系。在目标 2 中，我们将 确定多发性硬化症患者主观努力评估的机制。我们将使用 TMS 和 fMRI 研究多发性硬化症中努力价值的神经和行为表征。这些实验将揭示 多发性硬化症患者的神经回路因疲劳感而受到干扰。我们的研究 通过剖析基本原理，将对决策和运动控制领域产生广泛的影响 负责体力劳动评估的机制。这项工作将提供对神经网络的理解 多发性硬化症患者努力感觉受损的机制，可能最终揭示神经行为标志物 和神经调节干预措施，以帮助预测和治疗康复不依从性。