Neural and Behavioral Mechanisms of Angry Hostility in Depression
抑郁症中愤怒敌意的神经和行为机制
基本信息
- 批准号:10744840
- 负责人:
- 金额:$ 81.61万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-07-01 至 2028-04-30
- 项目状态:未结题
- 来源:
- 关键词:AdultAgeAggressive behaviorAmygdaloid structureAngerAreaAttentionBehaviorBehavior assessmentBehavioralBehavioral MechanismsClinicalClinical assessmentsCodeDataDepressed moodDetectionDevelopmentDiagnosticDimensionsEcological momentary assessmentElementsEmotionalEmotionsEvaluationFaceFeedbackFusiform gyrusFutureGoalsHostilityImpairmentIndividualInferior frontal gyrusInsula of ReilLaboratoriesLeadLifeLinkMeasuresMediatingMental DepressionMiddle frontal gyrus structureModelingMotorNational Institute of Mental HealthNeural PathwaysNeurobiologyNeuronal DysfunctionNeurophysiology - biologic functionOutcomeParticipantPatientsPatternPhenotypePrefrontal CortexProcessProtocols documentationQuality of lifeRecording of previous eventsRegulationRiskSensorySeveritiesShort-Term MemoryStandardizationSupport SystemSymptomsSystemTestingVisualWorkbasebrain dysfunctionburden of illnessdepressive symptomsdisabilityemotion regulationexperienceextrastriateextrastriate visual cortexfollow up assessmentfollow-upfunctional disabilityfunctional improvementfunctional outcomeshigh riskimproved outcomeindividualized medicineneuralneurobehavioralneuroimagingneuromechanismnovelpersonalized medicineprospectivepsychiatric symptomrecruitreduce symptomsresponsesexstressorsuicidal risktherapy developmenttreatment strategy
项目摘要
ABSTRACT
Despite the fact that multiple different treatments for depression have been available for decades, the global
burden of the illness has grown steadily. Depression is now one of the leading causes of disability worldwide.
Current treatment strategies for depression remain largely trial-and-error, and fewer than 40% of patients
respond to a given treatment and sustain that response for a year, even when treatment is continued. A central
barrier to improving these outcomes is the need to characterize better phenotypes of depressive illness that are
more closely aligned to modifiable neurobiological targets than are current symptom constellations and
diagnostic codes. Findings from our group, and from others, suggest that one such phenotype involves the
propensity to experience anger, hostility, and irritability following negative experiences and to respond in an
aggressive, overly hostile manner (hereafter denoted Angry Hostility). Our preliminary data suggest that the
Angry Hostility phenotype is associated with a particular pattern of altered functioning in neural regions that
support emotion processing and emotion regulation. Furthermore, Angry Hostility appears to be strongly
associated with hostile, aggressive behaviors following provocation and with real-world interpersonal and work-
functioning impairments that can exacerbate depressive symptoms. The primary goal of this project is to test a
novel model through which higher levels of Angry Hostility among adults with depression are associated with
specific patterns of abnormal neural function and behavior, leading to poor functional outcomes and future
symptoms. To achieve these goals, 150 adults (18-45 years old) with at least mild symptoms of depression will
be recruited, as will 100 demographically matched, psychiatrically healthy individuals. Participants will complete
clinical, neuroimaging, and laboratory behavioral assessments, as well as 4-, 8-, and 12-month follow-up
assessments and four 10-day ecological momentary assessment protocols. The project will examine 1) whether
Angry Hostility is associated with abnormal neural function in emotion processing and emotion regulation
regions; 2) whether Angry Hostility is associated with aggressive behaviors in the laboratory and in real-world
settings; and 3) whether abnormalities in a-priori neural systems and behaviors prospectively predict poorer real-
world functioning and psychiatric symptoms over the 12-month follow-up. The aims of the project match well with
the strategic goals of the National Institute of Mental Health. Moreover, the results of this study have the potential
to describe the neurobiological bases, behavioral mechanisms, and real-world consequences of elevated Angry
Hostility among adults with depression. Future work will aim to develop personalized treatments to target the
neural mechanisms identified in this study in order to reduce symptoms and improve functional outcomes for
adults with depression who have higher levels of Angry Hostility.
摘要
尽管抑郁症的多种不同治疗方法已经存在了几十年,
疾病的负担不断增加。抑郁症现在是全球残疾的主要原因之一。
目前抑郁症的治疗策略在很大程度上仍然是试错法,只有不到40%的患者
对特定的治疗有反应,并保持这种反应一年,即使继续治疗。中央
改善这些结果的障碍是需要更好地表征抑郁症的表型,
与当前症状星座相比,与可修改的神经生物学目标更紧密地对齐,
诊断代码我们小组和其他人的研究结果表明,其中一种表型涉及
在经历负面经历后,倾向于经历愤怒、敌意和易怒,并以一种
咄咄逼人,过于敌对的态度(下文称为愤怒的敌意)。我们的初步数据表明,
愤怒敌意表型与神经区域功能改变的特定模式有关,
支持情绪处理和情绪调节。此外,愤怒的敌意似乎强烈
与挑衅后的敌对、攻击行为以及现实世界中的人际关系和工作有关,
会加重抑郁症状的功能障碍这个项目的主要目标是测试一个
一种新的模型,通过该模型,成年抑郁症患者的愤怒敌意水平较高,
异常的神经功能和行为的特定模式,导致不良的功能结果和未来
症状为了实现这些目标,150名至少有轻度抑郁症状的成年人(18-45岁)将
招募100名人口统计学上匹配的精神健康个体。参与者将完成
临床、神经影像学和实验室行为评估,以及4、8和12个月随访
评估和四个为期10天的生态瞬时评估协议。该项目将审查1)是否
愤怒敌意与情绪加工和情绪调节的神经功能异常有关
2)愤怒的敌意是否与实验室和现实世界中的攻击行为有关
环境;以及3)先验神经系统和行为的异常是否可以前瞻性地预测较差的真实的
12个月随访期间的世界功能和精神症状。该项目的目标与
国家心理健康研究所的战略目标。此外,这项研究的结果有可能
描述神经生物学基础、行为机制和愤怒情绪升高的现实后果。
成人抑郁症患者的敌意。未来的工作将旨在开发个性化的治疗方法,以针对
本研究中确定的神经机制,以减少症状和改善功能结果,
愤怒敌意水平较高的抑郁症成年人。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Jay C Fournier其他文献
Jay C Fournier的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Jay C Fournier', 18)}}的其他基金
Bottom-Up Mechanisms of Dysfunctional Self Evaluation in Depression
抑郁症自我评价功能失调的自下而上机制
- 批准号:
10377165 - 财政年份:2021
- 资助金额:
$ 81.61万 - 项目类别:
Transdiagnostic Neural Mechanisms Underlying Dimensions of Negative Affectivity in Depression and Anxiety
抑郁和焦虑中消极情感维度的跨诊断神经机制
- 批准号:
10455635 - 财政年份:2018
- 资助金额:
$ 81.61万 - 项目类别:
Transdiagnostic Neural Mechanisms Underlying Dimensions of Negative Affectivity in Depression and Anxiety
抑郁和焦虑中消极情感维度的跨诊断神经机制
- 批准号:
10349731 - 财政年份:2018
- 资助金额:
$ 81.61万 - 项目类别:
Transdiagnostic Neural Mechanisms Underlying Dimensions of Negative Affectivity in Depression and Anxiety
抑郁和焦虑中消极情感维度的跨诊断神经机制
- 批准号:
9912199 - 财政年份:2018
- 资助金额:
$ 81.61万 - 项目类别:
Neural Markers of Individual Difference in Emotion Regulation in Depressed Adults
抑郁成人情绪调节个体差异的神经标志物
- 批准号:
8643292 - 财政年份:2013
- 资助金额:
$ 81.61万 - 项目类别:
Neural Markers of Individual Difference in Emotion Regulation in Depressed Adults
抑郁成人情绪调节个体差异的神经标志物
- 批准号:
8503117 - 财政年份:2013
- 资助金额:
$ 81.61万 - 项目类别:
相似国自然基金
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
- 批准号:JCZRQN202500010
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
- 批准号:2025JJ70209
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
- 批准号:
- 批准年份:2024
- 资助金额:0 万元
- 项目类别:面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
- 批准号:2023JJ50274
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
- 批准号:
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
- 批准号:n/a
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
- 批准号:81973577
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
- 批准号:81602908
- 批准年份:2016
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
- 批准号:81501928
- 批准年份:2015
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
相似海外基金
PROTEMO: Emotional Dynamics Of Protective Policies In An Age Of Insecurity
PROTEMO:不安全时代保护政策的情绪动态
- 批准号:
10108433 - 财政年份:2024
- 资助金额:
$ 81.61万 - 项目类别:
EU-Funded
The role of dietary and blood proteins in the prevention and development of major age-related diseases
膳食和血液蛋白在预防和发展主要与年龄相关的疾病中的作用
- 批准号:
MR/X032809/1 - 财政年份:2024
- 资助金额:
$ 81.61万 - 项目类别:
Fellowship
Atomic Anxiety in the New Nuclear Age: How Can Arms Control and Disarmament Reduce the Risk of Nuclear War?
新核时代的原子焦虑:军控与裁军如何降低核战争风险?
- 批准号:
MR/X034690/1 - 财政年份:2024
- 资助金额:
$ 81.61万 - 项目类别:
Fellowship
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341426 - 财政年份:2024
- 资助金额:
$ 81.61万 - 项目类别:
Continuing Grant
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341424 - 财政年份:2024
- 资助金额:
$ 81.61万 - 项目类别:
Continuing Grant
Doctoral Dissertation Research: Effects of age of acquisition in emerging sign languages
博士论文研究:新兴手语习得年龄的影响
- 批准号:
2335955 - 财政年份:2024
- 资助金额:
$ 81.61万 - 项目类别:
Standard Grant
The economics of (mis)information in the age of social media
社交媒体时代(错误)信息的经济学
- 批准号:
DP240103257 - 财政年份:2024
- 资助金额:
$ 81.61万 - 项目类别:
Discovery Projects
How age & sex impact the transcriptional control of mammalian muscle growth
你多大
- 批准号:
DP240100408 - 财政年份:2024
- 资助金额:
$ 81.61万 - 项目类别:
Discovery Projects
Supporting teachers and teaching in the age of Artificial Intelligence
支持人工智能时代的教师和教学
- 批准号:
DP240100111 - 财政年份:2024
- 资助金额:
$ 81.61万 - 项目类别:
Discovery Projects
Enhancing Wahkohtowin (Kinship beyond the immediate family) Community-based models of care to reach and support Indigenous and racialized women of reproductive age and pregnant women in Canada for the prevention of congenital syphilis
加强 Wahkohtowin(直系亲属以外的亲属关系)以社区为基础的护理模式,以接触和支持加拿大的土著和种族育龄妇女以及孕妇,预防先天梅毒
- 批准号:
502786 - 财政年份:2024
- 资助金额:
$ 81.61万 - 项目类别:
Directed Grant