Early Stage Training in the Neurosciences

项目摘要/摘要。继续支持我们的培训赠款，在 2001年在密歇根大学(UM)建立的神经科学(ESTN)，这是要求的。目标是 这笔赠款是神经科学研究生计划(NGP)的核心内容，目的是为 在神经科学方面受过广泛训练的优秀博士后。这将为他们的职业生涯做好准备 帮助满足国家基础科学和生物医学研究需求。一些令人兴奋的新变化已经 发生在ESTN/NGP中，包括新的领导团队、新的最先进的设施和资源、 充满活力的新一批年轻神经科学教员，卡夫利学者，以及修订后的课程和考试 格式以更好地为我们的学生做好准备。要有资格获得ESTN支持，学生必须被NGP录取， 密歇根大学最具选择性的生物医学课程，通过直接录取或PIBS录取 雨伞。在第一年，学生完成一门基础广泛的神经科学课程，包括：神经科学 “训练营”、神经科学原理、人类神经解剖学、统计学、研究责任和伦理，以及 神经科学研究研讨会，除了进行实验室研究轮换。到了年底， 学生参加他们的资格考试。在他们的第二年，学生们选修课程，在 神经科学研讨会课程，完成NRSA的拨款，并从事博士研究。ESTN包括 代表5所学校或学院19个系的85名教职员工。学术分布广，实力雄厚 ESTN教职员工的研究经费和高水平的同行认可与此应用程序非常匹配 专注于广泛的早期神经科学培训。学员将接触到广泛的研究领域 包括：分子和细胞神经科学；发育神经科学；感觉神经科学； 认知神经科学；行为和系统神经科学；计算神经科学；临床和 翻译神经科学。在完成培训后，我们的毕业生将准备处理一系列基本的 神经科学和/或公共卫生问题，从神经退行性疾病的分子基础到 精神疾病中的脑回路异常。密歇根大学的NGP有招聘的历史 并培训来自代表性不足群体的学生，但仍努力继续增加其 实习生。我们的成就和继续招聘、留住和发展成功的详细计划 突出了神经科学研究中代表性不足的博士生。我们还提出了详细的计划 指导、专业发展、项目评估，以及定量方法和 负责任的研究行为。总而言之，密歇根ESTN为未来提供出色的培训 一所主要研究型大学背景下的神经科学家。

Project Summary/Abstract. Continuing support of our training grant, ‘Early Stage Training in the Neurosciences’ (ESTN), which was founded at the University of Michigan (UM) in 2001, is requested. The goal of this grant, which is a centerpiece of the Neuroscience Graduate Program (NGP), is to provide a cadre of exceptional predoctoral students with broad training in neuroscience. This will prepare them for careers that will help to meet the nation’s basic science and biomedical research needs. A number of exciting new changes have occurred in the ESTN/NGP including a new leadership team, new state-of-the-art facilities and resources, a dynamic new cohort of young neuroscience faculty, the Kavli Scholars, and a revised curriculum and examination format to better prepare our students. To be eligible for ESTN support, students must be admitted to the NGP, the most selective biomedical science program at UM, through either direct admit or the PIBS admission umbrella. In the first year, students complete a broad-based neuroscience curriculum that includes: neuroscience “bootcamp”, principles of neuroscience, human neuroanatomy, statistics, research responsibility and ethics, and neuroscience research seminar, in addition to performing laboratory research rotations. At the end of the year, students take their Qualifying Exam. In their second year, students take electives, give oral presentations in the Neuroscience seminar course, complete an NRSA grant and work on their doctoral research. The ESTN consists of 85 faculty representing 19 departments in 5 schools or colleges. The wide academic distribution, strong research funding and high-level of peer recognition of the ESTN faculty excellently matches this application’s focus on broad early stage neuroscience training. Trainees are exposed to a broad range of research areas including: Molecular and Cellular Neuroscience; Developmental Neuroscience; Sensory Neuroscience; Cognitive Neuroscience; Behavioral and Systems Neuroscience; Computational Neuroscience; and Clinical and Translational Neuroscience. Upon completion of training, our graduates are poised to tackle a host of basic neuroscience and/or public health issues ranging from the molecular basis of neurodegenerative disorders to brain circuit abnormalities in psychiatric disease. The NGP at University of Michigan has a history of recruiting and training students from underrepresented groups, yet strives to continue to increase the diversity of its trainees. Our accomplishments and a detailed plan for continuing to recruit, retain and develop successful underrepresented Ph.D. trainees in neuroscience research are highlighted. We also present detailed plans for mentoring, professional development, evaluation of the program, and for instruction in quantitative methods and the responsible conduct of research. Taken together, the Michigan ESTN provides outstanding training to future neuroscientists within the setting of a major research university.