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Preventing Falls and Frailty in Prostate Cancer Survivors: GET FIT Prostate

预防前列腺癌幸存者跌倒和虚弱：GET FIT Prostate

基本信息

批准号：
10439785
负责人：
KERRI M WINTERS-STONE
金额：
$ 63.29万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-23 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10439785
关键词：
Address Aging Androgens Cancer Survivor Cancer Survivorship Caring Cessation of life Clinical Clinical Treatment Communities Control Groups Drops Elderly Ensure Equilibrium Ethics Evidence based program Exercise Exposure to Fall prevention Fracture Functional disorder Future Goals Guidelines Health Health Benefit Incidence Injury Integration Host Factors Intervention Knowledge Lead Life Link Literature Malignant Neoplasms Medical Care Costs Modality Morbidity - disease rate Muscular Atrophy Oncology Outcome Study Patient Self-Report Patients Pattern Physical Function Placebo Control Placebos Population Prevalence Prevention program Prevention strategy Property Prostate Prostate Cancer therapy Provider Public Health Quality of life Randomized Controlled Trials Recommendation Rehabilitation therapy Reporting Research Risk Single-Blind Study Sleep Stretching Structure Supervision Survivors Tai Ji Testing Therapeutic Time Training Treatment Factor androgen deprivation therapy attentional control base cancer care cancer survival cancer therapy clinical practice comparative efficacy conventional therapy cost design disability efficacy trial evidence base exercise intervention exercise program exhaustion fall risk falls follow-up frailty head-to-head comparison high risk improved injury-related death innovation insight men mode of exercise mortality muscle strength novel older men patient oriented patient population placebo group prevent primary outcome programs prostate cancer survivors randomized controlled design secondary outcome side effect strength training tumor

项目摘要

Based on recent findings from our team and others, we confirm initial reports that prostate cancer (PC) survivors treated with androgen deprivation therapy (ADT) are significantly more likely to fall and to become frail than PC survivors who do not receive this treatment or men without cancer, placing nearly half of all PC survivors at higher risk of fall-related fractures, other life-threatening injuries, disability and death. Currently, there are no evidence-based fall prevention strategies that specifically target PC survivors on ADT. The purpose of the proposed study is to determine and compare the efficacy of two very distinct types of exercise, tai chi versus strength training, to prevent falls specifically linked to ADT for prostate cancer. We will examine additional endpoints of frailty and physical function that are also worsened with ADT and contribute to the risk of falls and future disability. We propose a 3-group, single-blind, parallel design, randomized controlled trial in PC survivors treated with ADT (N=360) comparing 1) tai chi to 2) strength training against 3) a placebo control group of seated stretching exercise. Men will participate in supervised study programs 3x/wk for 6 months and will be followed for 6 more months after formal training stops. The specific aims of this study are to determine and compare the efficacy of both tai chi and strength training to 1) reduce falls and 2) lessen frailty (shrinking, weakness, slowness, exhaustion, and inactivity) and dysfunction (mobility, balance, self-report function) in PC survivors on ADT, 3) Determine whether or not the benefits of each intervention last after structured training stops and 4) Explore the patterns and predictors of men who respond best to each intervention. The proposed study is innovative in its approach because it applies two well-characterized fall prevention exercise programs (e.g., tai chi and strength training) to a new population just recently identified at high risk of falls and for whom the causes of falls and effective countermeasures remain unclear. This study is the very first attempt at a direct comparison of two known exercise modalities, each with distinct training properties, to reduce falls, frailty and dysfunction in PC survivors. The proposed project responds to an urgent research agenda in cancer survivorship that calls for developing appropriately targeted, effective, and sustainable exercise programs for cancer survivors and to NCI and IOM priorities to expand cancer care to prevent disability in older survivors. This study is relevant to public health because up to 45% of the 2 million PCS alive in the U.S. are prescribed ADT. Men on ADT can survive 16 years or longer, lengthening the time they grow susceptible to falls, frailty and dysfunction from aging and cancer treatment, yet there are no evidence-based therapeutic treatment options for these men. This study addresses this significant barrier in clinical practice by proposing a safe, low- cost, and scalable exercise-based approach. If the aims are achieved, an effective solution to prevent falls and reduce frailty associated with ADT will be readily available to clinical and rehabilitative practice. Importantly, this study would address a NCI Cancer MoonshotSM goal to reduce cancer's debilitating side effects.

根据我们团队和其他人最近的发现，我们证实了前列腺癌（PC）

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Protocol for GET FIT Prostate: a randomized, controlled trial of group exercise training for fall prevention and functional improvements during and after treatment for prostate cancer.

DOI：
10.1186/s13063-021-05687-7
发表时间：
2021-11-06
期刊：
Trials
影响因子：
2.5
作者：
Winters-Stone KM;Li F;Horak F;Dieckmann N;Hung A;Amling C;Beer TM
通讯作者：
Beer TM

A cognitively enhanced online Tai Ji Quan training intervention for community-dwelling older adults with mild cognitive impairment: A feasibility trial.

DOI：
10.1186/s12877-021-02747-0
发表时间：
2022-01-25
期刊：
BMC geriatrics
影响因子：
4.1
作者：
Li F;Harmer P;Fitzgerald K;Winters-Stone K
通讯作者：
Winters-Stone K

Tai Chi for cancer survivors: A systematic review toward consensus-based guidelines.

DOI：
10.1002/cam4.4273
发表时间：
2021-11
期刊：
Cancer medicine
影响因子：
4
作者：
Yang L;Winters-Stone K;Rana B;Cao C;Carlson LE;Courneya KS;Friedenreich CM;Schmitz KH
通讯作者：
Schmitz KH