Nanovaccine for eliciting 10E8-like bnAbs against HIV-1

作为下一代HIV疫苗的基于颗粒的HIV免疫原共递送：定制的免疫原（如Envs、单体、天然和/或天然样三聚体、核酸/RNA如mrna、自我扩增RNA）与有效的多价抗原结合在纳米颗粒上进行递送，可能提供一种策略，以促进抗HIV的强效和长寿命的中和抗体反应，并直接向HIV中和抗体亲和力成熟。该合同的目的是开发、评估和优化基于纳米粒子的平台，以引发针对HIV-1 gp41蛋白的膜近端外区（MPER）的广泛中和抗体。

Particle-based Co-delivery of HIV immunogens as Next-generation HIV Vaccines: Tailored immunogens (such as Envs, monomers, native and/or native-like trimers, nucleic acids/RNA such as mRNAs, self-amplifying RNAs) combined with an effective multivalent antigenic display on nanoparticles for delivery may provide a strategy to promote strong and long-lived neutralizing antibody responses against HIV and direct affinity maturation toward HIV neutralizing antibodies. The objective of this contract is to develop, evaluate, and optimize nanoparticle-based platforms to elicit broadly neutralizing antibodies against the membrane proximal external region (MPER) of the HIV-1 gp41 protein.