Nanovaccine for eliciting 10E8-like bnAbs against HIV-1

基于粒子的HIV免疫原共传递作为下一代HIV疫苗：定制的免疫原(如env、单体、天然和/或天然样三聚体、核酸/RNA如mRNAs、自我扩增RNAs)与用于传递的纳米颗粒上有效的多价抗原展示相结合，可能提供一种策略来促进针对HIV的强大而持久的中和抗体应答和对HIV中和抗体的直接亲和力成熟。该合同的目标是开发、评估和优化基于纳米颗粒的平台，以诱导针对HIV-1 gp41蛋白的膜近端外部区域(MPER)的广泛中和抗体。

Particle-based Co-delivery of HIV immunogens as Next-generation HIV Vaccines: Tailored immunogens (such as Envs, monomers, native and/or native-like trimers, nucleic acids/RNA such as mRNAs, self-amplifying RNAs) combined with an effective multivalent antigenic display on nanoparticles for delivery may provide a strategy to promote strong and long-lived neutralizing antibody responses against HIV and direct affinity maturation toward HIV neutralizing antibodies. The objective of this contract is to develop, evaluate, and optimize nanoparticle-based platforms to elicit broadly neutralizing antibodies against the membrane proximal external region (MPER) of the HIV-1 gp41 protein.