GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS

对微生物抗原的抗体反应的遗传控制

• 批准号: 4688363
• 负责人: P J BAKER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4688363
• 关键词: B lymphocyte; Escherichia coli; Streptococcus pneumoniae; active immunization; antibody formation; antibody specificity; bacterial genetics; bacterial polysaccharides; exotoxins; gene complementation; genetic markers; genetic recombination; genetic regulation; genetic strain; immune tolerance /unresponsiveness; immunogenetics; immunosuppressive antileukocyte serum; leukocyte activation /transformation; linkage mapping; microorganism antigen; microorganism immunology

B6.C congenic strains of mice, possessing chromosomal segments from high-responding BALB/cByJ (C) mice on the genetic background of low-responding C57BL/6ByJ (B6) mice, were examined for their ability to make an antibody response to Type III pneumococcal polysaccharide (SSS-III) and the alpha 1 yield 3 determinant of bacterial (Leuconostoc) dextran B-1355. The results obtained affirmed that genes making a positive contribution to responsiveness to SSS-III are located on different chromosomes, i.e., chromosomes 1,3,4,5, and 9. At least one other gene also influences responsiveness to this antigen; it it closely linked to the H-17 locus which has not yet been assigned to a specific chromosome. Genes on chromosomes 1,4, and 5 were found to influence the magnitude of the antibody response to dextran B-1355. Some of these genes appear to be antigen-specific in their mode of action; however, others are not since they exert an influence on the antibody response to both SSS-III and dextran B-1355.

B6.C小鼠同源品系，具有来自