GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS

B6.C小鼠同源品系，具有来自 高反应BALB/cByJ（C）小鼠的遗传背景 低应答C57 BL/6 ByJ（B6）小鼠，检查它们的能力， 对III型肺炎球菌多糖（SSS-III）产生抗体反应 和细菌（明串珠菌属）葡聚糖的α 1产量3决定簇 B-1355。 所获得的结果证实， 对SSS-III响应性的贡献位于不同的 染色体，即，染色体1，3，4，5和9。 至少还有一个基因 也会影响对这种抗原的反应;它与 H-17基因座，尚未被分配到一个特定的染色体。 基因 在染色体1，4和5被发现影响的大小， 对葡聚糖B-1355的抗体应答。 其中一些基因似乎 抗原特异性的作用模式;然而，其他人不是因为 它们影响对SSS-III和 葡聚糖B-1355。

B6.C congenic strains of mice, possessing chromosomal segments from high-responding BALB/cByJ (C) mice on the genetic background of low-responding C57BL/6ByJ (B6) mice, were examined for their ability to make an antibody response to Type III pneumococcal polysaccharide (SSS-III) and the alpha 1 yield 3 determinant of bacterial (Leuconostoc) dextran B-1355. The results obtained affirmed that genes making a positive contribution to responsiveness to SSS-III are located on different chromosomes, i.e., chromosomes 1,3,4,5, and 9. At least one other gene also influences responsiveness to this antigen; it it closely linked to the H-17 locus which has not yet been assigned to a specific chromosome. Genes on chromosomes 1,4, and 5 were found to influence the magnitude of the antibody response to dextran B-1355. Some of these genes appear to be antigen-specific in their mode of action; however, others are not since they exert an influence on the antibody response to both SSS-III and dextran B-1355.