GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS

对微生物抗原的抗体反应的遗传控制

• 批准号: 3818114
• 负责人: P J BAKER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3818114
• 关键词: B lymphocyte; active immunization; antibody formation; antibody specificity; antigen antibody reaction; antiserum; bacterial antigens; bacterial genetics; bacterial polysaccharides; erythrocytes; genetic regulation; genetic strain; immune tolerance /unresponsiveness; immunogenetics; immunoglobulin G; immunoglobulin M; immunologic memory; immunosuppressive antileukocyte serum; laboratory mouse; leukocyte activation /transformation; lipopolysaccharides; microorganism antigen; microorganism immunology; transferrin

RIIIS/J mice make low antibody responses to several polysaccharide antigens of bacterial origin. They have low levels of serum IgM and IgG3, and high levels of serum IgG2a and IgG2b. Low serum IgM and IgG3 levels appear to be due to a low frequency of Ly-1 B cells. RIIIS/J mice treated with bacterial lipopolysaccharide (LPS) produce a low anti-bromelain-mouse-erythrocyte (anti-BrMRBC) antibody response, but a normal antibody response against mouse transferrin. These data are consistent with the fact that Ly-1 B cells contain the precursors of B lymphocytes secreting anti-BrMRBC antibody. RIIIS/J mice should be valuable in studies on the development of the Ly-1 B cell lineage.

RIIIS/J小鼠对几种多糖产生低抗体应答 细菌来源的抗原。 他们的血清IgM水平很低 血清IgG 2a和IgG 2b水平升高。 低血清IgM 和IgG 3水平似乎是由于低频率的Ly-1 B 细胞 用细菌脂多糖处理的RIIIS/J小鼠 (LPS)产生低抗菠萝蛋白酶小鼠红细胞（抗BrMRBC） 抗体反应，但对小鼠的正常抗体反应 转铁蛋白 这些数据与Ly-1 B 细胞含有分泌抗BrMRBC的B淋巴细胞的前体 抗体的 RIIIS/J小鼠在研究中应该是有价值的。 Ly-1 B细胞谱系的发育。