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GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS

GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS
对微生物抗原的抗体反应的遗传控制
批准号：
3818114
负责人：
P J BAKER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3818114
关键词：
B lymphocyte active immunization antibody formation antibody specificity antigen antibody reaction antiserum bacterial antigens bacterial genetics bacterial polysaccharides erythrocytes genetic regulation genetic strain immune tolerance /unresponsiveness immunogenetics immunoglobulin G immunoglobulin M immunologic memory immunosuppressive antileukocyte serum laboratory mouse leukocyte activation /transformation lipopolysaccharides microorganism antigen microorganism immunology transferrin

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中文摘要
翻译
RIIIS/J小鼠对几种多糖的低抗体反应 细菌来源的抗原。他们的血清免疫球蛋白水平较低。 和IgG3，血清IgG2a和IgG2b水平升高。低血清IgM 而IgG3水平似乎是由于Ly-1B的低频率所致 细胞。细菌内毒素对RIIIS/J小鼠的治疗作用 (脂多糖)产生低抗菠萝蛋白酶-小鼠-红细胞(抗BrMRBC) 抗体反应，但对小鼠的正常抗体反应 转铁蛋白。这些数据与Ly-1B 细胞含有分泌抗BrMRBC的B淋巴细胞前体 抗体。RIIIS/J小鼠在人类免疫缺陷病毒的研究中具有重要价值 Ly-1B细胞系的发育。
英文摘要
RIIIS/J mice make low antibody responses to several polysaccharide antigens of bacterial origin. They have low levels of serum IgM and IgG3, and high levels of serum IgG2a and IgG2b. Low serum IgM and IgG3 levels appear to be due to a low frequency of Ly-1 B cells. RIIIS/J mice treated with bacterial lipopolysaccharide (LPS) produce a low anti-bromelain-mouse-erythrocyte (anti-BrMRBC) antibody response, but a normal antibody response against mouse transferrin. These data are consistent with the fact that Ly-1 B cells contain the precursors of B lymphocytes secreting anti-BrMRBC antibody. RIIIS/J mice should be valuable in studies on the development of the Ly-1 B cell lineage.
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GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS
GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS
REGULATION OF THE ANTIBODY RESPONSE TO MICROBIAL POLYSACCHARIDE ANTIGENS
MODE OF ACTION OF THYMUS DERIVED (T) SUPPRESSOR AND AMPLIFIER CELLS
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