REGULATION OF THE ANTIBODY RESPONSE TO MICROBIAL POLYSACCHARIDE ANTIGENS

微生物多糖抗原抗体反应的调节

• 批准号: 3821967
• 负责人: P J BAKER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3821967
• 关键词: Escherichia coli; Streptococcus pneumoniae; T lymphocyte; antibody formation; antibody specificity; antigen antibody reaction; autoantibody; bacterial antigens; bacterial polysaccharides; genetic regulation; hybridomas; immune tolerance /unresponsiveness; immunogenetics; immunoglobulin genes; immunologic memory; immunoregulation; immunosuppressive; leukocyte activation /transformation; lipopolysaccharides; microorganism immunology; suppressor T lymphocyte; surface antigens

Although prior treatment with subimmunogenic amounts of some preparations of bacterial lipopolysaccharide (LPS) results in the development of immunological memory, prior exposure to others results in profound unresponsiveness or suppression. The results of preliminary experiments suggest that the later may be mediated by a subset of T cells possessing the Lyt2 cell-surface antigen. Extracts of mannan derived from Candida albicans can both enhance and suppress antibody responses to unrelated antigen. These immunomodulatory effects can be separated on the basis of molecular size and charge, indicating that they are mediated by distinct components present in extracts of mannan.

尽管先前用亚免疫原性量的一些 细菌脂多糖（LPS）的制备导致 免疫记忆的发展，之前暴露于他人 导致严重的反应迟钝或压抑。 结果 初步实验表明，后者可能是 由具有Lyt2细胞表面的T细胞亚群介导 抗原的 来源于白色念珠菌的甘露聚糖提取物既可以 增强和抑制对无关抗原的抗体应答。 这些免疫调节作用可以根据以下因素分开： 分子大小和电荷，表明它们是由 甘露聚糖提取物中存在的不同成分。