临床试验网络俄亥俄谷节点-猫眼课题宝

临床试验网络俄亥俄谷节点

批准号：

10441828

负责人：

T John WINHUSEN

金额：

$3.32万

依托单位：

UNIVERSITY OF CINCINNATI

依托单位国家：

美国

项目类别：

财政年份：

2021

资助国家：

美国

项目状态：

已结题

起止时间：

2021-07-01 至 2022-02-28

来源：

https://reporter.nih.gov/project-details/10441828

关键词：

Abstinence Acceleration Acquired Immunodeficiency Syndrome Address Adherence Adolescent Adult Affect African American Age Alcohols Anxiety Anxiety Disorders Back Behavior Behavior Therapy Behavioral Model Benzodiazepines Biography Black, Indigenous, People of Color Budgets Bupropion Calibration Categories Caucasians Cessation of life Characteristics Child Clinic Clinical Clinical Data Clinical Treatment Clinical Trials Clinical Trials Network Cocaine Cocaine Dependence Cocaine Users Cognitive Therapy Collection Color Communities Counseling Data Data Aggregation Data Analyses Data Collection Data Pooling Data Set Databases Death Rate Diagnostic Disease Drug abuse Education Effect Modifiers (Epidemiology)Effectiveness Employment Enrollment Ethnic Origin Ethnic group Evaluation Evidence based treatment Factor Analysis Fentanyl Frequencies Funding Gender Identity Glass Goals Grant Growth Harm Reduction Health Health Services Accessibility Health behavior Heroin Hispanics Incentives Individual Institution Institutional Review Boards Intercept Interest Group International Intervention Jordan Knowledge Latinx Learning Life Style Link Literature Long-Term Effects Measurement Measures Medical Meta-Analysis Methamphetamine Methodology Methods Minority Modality Modeling Motivation National Institute of Drug Abuse National Institute of Mental Health National Institute on Alcohol Abuse and Alcoholism Neighborhoods Ohio Opioid Outcome Outpatients Paper Participant Patient Self-Report Patient-Focused Outcomes Patients Perception Pharmaceutical Preparations Pharmacological Treatment Pharmacotherapy Population Positioning Attribute Post-Traumatic Stress Disorders Privatization Process Property Protocols documentation Provider Psychiatric therapeutic procedure Psychiatrist Psychiatry Psychosocial Factor Public Health Publications Publishing Race Randomized Randomized Clinical Trials Readiness Reporting Research Research Design Research Methodology Research Personnel Research Project Grants Resources Review Literature Risk Role Safety Sampling Self Efficacy Severities Site Smoker Social Conditions Socioeconomic Factors Source Stress Subgroup Substance Addiction Substance Use Disorder Substance abuse problem System Testing Therapeutic Time Time trend TimeLine Tobacco Use Disorder Toxicology Training Trauma Treatment Effectiveness Treatment Efficacy Treatment outcome Underrepresented Minority Underrepresented Populations United States Urine Validation Variant Veins Vital Statistics Weight Woman Work Writing active method addiction alcohol abuse therapy base black subgroup career childhood anxiety clinically significant cocaine overdose cocaine use comorbidity comparative effectiveness comparative efficacy compare effectiveness contextual factors cooking cultural competence data harmonization design dual diagnosis education research effectiveness evaluation efficacy evaluation ethnic difference ethnic diversity evidence base experience follow-up health care quality health difference health disparity improved individual patient innovation interest marijuana use meetings men men&apos s group methadone clinic/center motivational enhancement therapy multi-racial multidisciplinary multilevel analysis nicotine patch novel opioid epidemic opioid mortality opioid use overdose death patient subsets pregnant primary outcome programs psychosocial psychostimulant racial and ethnic racial and ethnic disparities racism rate of change response rural African American science education screening, brief intervention, referral, and treatment secondary analysis secondary outcome sex social social factors social health determinants sociodemographic factors sociodemographics statistics structured data substance abuse treatment substance use substance use treatment substance user symposium synergism synthetic opioid theories treatment adherence treatment arm treatment effect treatment program treatment trial young adult young man

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中文摘要

翻译

使用综合数据分析来检查心理社会治疗对黑人吸毒者加入NIDA药物滥用治疗临床试验网络（CTN）具体目标最近的报告显示，黑人阿片类药物过量死亡的加速现在超过了白色人。1这种增长是由于合成的可卡因供应中的阿片类药物（芬太尼）在阿片类药物过量死亡中约占三分之一。有限的工作表明，治疗效果可能因种族而异- 种族群体。然而，这些研究中只有一小部分专门研究了可卡因的使用。的 CTN提供了一个独特的，但未充分探索的研究收集，可以提高我们的知识对吸食可卡因的黑人进行有效的心理治疗拟定的研究将联合收割机数据来自7项CTN治疗研究（总N = 1442名黑人受试者），组合呈现混合的结果。使用多种新兴测量/数据分析框架（综合数据分析（IDA），个体患者数据的荟萃分析（MIPD），因果适度分析），拟议研究的目标是评估对使用可卡因的黑人进行物质使用障碍治疗的有效性。该项目有三个具体目标：目的1：估计可卡因使用严重程度的量表评分，同时考虑研究水平测量不变性目的2：比较可卡因使用严重程度循证治疗模型的有效性。目的3：探索个体和研究水平的调节因素，如合并使用阿片类药物，年龄，性别、就业情况、治疗前精神状态和保留情况，以评价亚组治疗效果的差异。

英文摘要

Using Integrative Data Analysis to Examine the Impact of Psychosocial Treatments for Black Cocaine Users Enrolled in the NIDA Drug Abuse Treatment Clinical Trials Network (CTN) Specific Aims Recent reports reveal that the acceleration of opioid-involved overdose deaths for Black people now outpaces that of White people.1 This increase is attributable to the presence of synthetic opioids (fentanyl) in the cocaine supply in approximately one third of opioid overdose deaths. The limited body of work available suggests that treatment effectiveness may vary across racial- ethnic groups. Yet, only a subset of these studies have specifically looked at cocaine use. The CTN provides a unique but underexplored collection of studies that can improve our knowledge on effective psychosocial treatments for Black people who use cocaine. The proposed study will combine data from 7 CTN treatment studies (total N = 1442 Black participants) that in combination present mixed findings. Using multiple emerging measurement/data analysis frameworks (integrative data analysis (IDA), meta-analysis of individual patient data (MIPD), causal moderation analysis), the goal of the proposed study is to evaluate the effectiveness of substance use disorder treatments for Black people who use cocaine. The project has three specific aims: Aim 1: Estimate scale scores of cocaine use severity while considering study-level measurement non-invariance. Aim 2: Compare the effectiveness of evidence-based treatment models for cocaine use severity. Aim 3: Explore individual- and study-level moderators, such as concomitant opioid use, age, sex, employment, pre-treatment psychiatric status, and retention to evaluate subgroup differences in treatment effectiveness.

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