A tailored, peer-delivered intervention to reduce recurring opioid overdoses

量身定制的、同行提供的干预措施，以减少反复出现的阿片类药物过量

• 批准号: 9015947
• 负责人: T John WINHUSEN
• 金额: $ 22.52万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9015947
• 关键词: Accounting; Acute; Certification; Cessation of life; Clinical Trials; Competence; Control Groups; Effectiveness; Emergency Care; Emergency department visit; Enrollment; Epidemic; Evidence based intervention; Factor Analysis; Feedback; Fright; Future; Health; Hour; Individual; Intervention; Knowledge; Mediation; Mediator of activation protein; Methods; Modeling; Morbidity - disease rate; Naloxone; Opioid; Overdose; Participant; Patients; Persons; Persuasive Communication; Pharmaceutical Preparations; Preparation; Preventive Intervention; Publishing; Randomized; Recruitment Activity; Recurrence; Reporting; Risk; Risk Factors; Risk Reduction; Secondary Prevention; Self Efficacy; Staging; Structure; Surveys; Telephone; Testing; Time; Training; United States; base; computer program; cost; design; disability; experience; medication-assisted treatment; opioid use; opioid use disorder; peer; pilot trial; prevent; satisfaction

 DESCRIPTION (provided by applicant): In recent years, the United States has experienced a growing opioid-use epidemic accompanied by a dramatic rise in opioid-overdose (OOD). Individuals experiencing a non-fatal OOD are at heightened risk for future OODs. A recent study revealed that patients with repeated OODs accounted for 15% of all OOD ED visits, and were more likely to be hospitalized. Although naloxone can reverse an acute overdose, there is no guarantee the medication will be available in time. The only completely effective method of preventing subsequent OOD is successful treatment of the underlying opioid use disorder (OUD). Despite this, there are no published interventions to facilitate treatment entry for patient experiencing a non-fatal OOD. To fill this gap, we created the Tailored Telephone Intervention delivered by Peers to Prevent Recurring Opioid Overdoses (TTIP-PRO), a secondary prevention intervention for individuals with OUD and a recent OOD designed to: 1) encourage patients to initiate medication assisted treatment (MAT) and 2) increase knowledge about OOD risk reduction. To maximize effectiveness, TTIP-PRO was designed based on principles from the elaboration likelihood model (ELM) of persuasion. Based on the ELM, TTIP-PRO is patient-tailored, provides empirically-based information in a multimodal format, and is delivered by a Peer Interventionist - a person who has been abstinent from illicit opioids for at least a year, is enrolled in MAT, and has personal experience with OOD. To minimize cost and implementation barriers, TTIP-PRO is provided remotely and consists of: 1) a 30-minute telephone call during which the Peer Interventionist engages the individual in an open discussion about MAT and provides tailored feedback based on the individual's OOD risk factors and knowledge about OOD and MAT; 2) a mailing with materials to reinforce the patient's knowledge of his/her personal risk factors, review how to appropriately respond to an OOD, re-emphasize the benefits of MAT, and remind the participant where he/she can obtain treatment. Because the TTIP-PRO computer program generates tailored feedback and guides the Peer Interventionist through intervention delivery, TTIP-PRO training and certification can be accomplished in 4 hours. Our initial study evaluating the acceptability of TTIP-PRO revealed a high degree of satisfaction with TTIP-PRO for both Peer Interventionists and participants and a significant increase in the participants' knowledge about OOD and MAT. The specific aims of this project are to: 1) Finalize the Peer Interventionist training materials by creating training files and evaluating the inter-rater reliability of TTIP-PRO's competence assessment (Stage IA); and 2) Conduct pilot testing in preparation for a full-scale clinical trial (Stage IB). Exploratory aims ae to: E1) Test the validity of two assessments developed for TTIP-PRO; E2) Test our conceptual model of TTIP-PRO's mechanisms of change.

 描述（由申请人提供）：近年来，美国经历了日益增长的阿片类药物使用流行病，伴随着阿片类药物过量（OOD）的急剧上升。经历非致命OOD的个体未来OOD的风险更高。最近的一项研究显示，反复OOD的患者占所有OOD艾德就诊的15%，并且更有可能住院。虽然纳洛酮可以逆转急性过量，但不能保证药物将及时提供。预防后续OOD的唯一完全有效的方法是成功治疗潜在的阿片类药物使用障碍（OUD）。尽管如此，没有发表的干预措施来促进非致死性OOD患者的治疗入组。为了填补这一空白，我们创建了由同行提供的量身定制的电话干预，以防止复发阿片类药物过量（TTIP-PRO），这是OUD和最近OOD患者的二级预防干预措施，旨在：1）鼓励患者开始药物辅助治疗（MAT）和2）增加有关OOD风险降低的知识。为了最大限度地提高效率，TTIP-PRO是根据说服的阐述可能性模型（ELM）的原则设计的。基于ELM，TTIP-PRO是为患者量身定制的，以多模式格式提供基于药物的信息，并由同行干预者提供-一个已经戒除非法阿片类药物至少一年的人， 在MAT注册，并有OOD的个人经验。为了最大限度地减少成本和实施障碍，TTIP-PRO是远程提供的，包括：1）一个30分钟的电话，在此期间，同伴干预者与个人进行关于MAT的公开讨论，并根据个人的OOD风险因素和对OOD和MAT的了解提供量身定制的反馈; 2）邮寄材料，以加强患者对其个人风险因素的了解，回顾如何适当应对OOD，再次强调MAT的好处，并提醒参与者他/她可以在哪里获得治疗。由于TTIP-PRO计算机程序生成量身定制的反馈，并通过干预提供指导同行干预医生，TTIP-PRO培训和认证可以在4小时内完成。我们评估TTIP-PRO可接受性的初步研究显示，同伴干预者和参与者对TTIP-PRO的满意度都很高，参与者对OOD和MAT的知识也有显著增加。该项目的具体目标是：1）通过创建培训文件和评估TTIP-PRO能力评估的评估者间可靠性（IA阶段），最终确定同伴干预培训材料; 2）进行试点测试，为全面临床试验做准备（IB阶段）。探索性研究旨在：E1）测试为TTIP-PRO开发的两种评估的有效性; E2）测试我们关于TTIP-PRO变化机制的概念模型。