The Ohio Valley Node of the Clinical Trials Network

临床试验网络俄亥俄谷节点

• 批准号: 10583134
• 负责人: T John WINHUSEN
• 金额: $ 153.74万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10583134
• 关键词: Accident and Emergency department; Address; African American; Appalachian Region; Area; Artificial Intelligence; Behavior Therapy; Bioinformatics; Buprenorphine; Clinic; Clinical; Clinical Treatment; Clinical Trials; Clinical Trials Network; Cocaine use disorder; Communicable Diseases; Communities; Conduct Clinical Trials; Cultural Diversity; Data; Data Set; Databases; Drug abuse; Electronic Health Record; Enrollment; Ensure; Epidemic; FDA approved; Formulation; Funding; Geography; Goals; Health Personnel; Health Services; Healthcare; Healthcare Systems; Hospitals; Infrastructure; Institution; Intervention; Investigational Drugs; Kentucky; Leadership; Methamphetamine; Mission; Missouri; Multi-Institutional Clinical Trial; National Institute of Drug Abuse; Native Americans; North Dakota; Ohio; Opioid; Participant; Patients; Performance; Perinatal; Pharmaceutical Preparations; Pharmacists; Pharmacy facility; Pregnant Women; Primary Health Care; Productivity; Public Health; Randomized; Recording of previous events; Research; Research Personnel; Serine; Services; Site; South American; Substance Use Disorder; Sum; System; Technology; Testing; West Virginia; Work; addiction; adverse event risk; base; behavioral health; clinical center; clinical practice; clinical trial participant; design; driving force; effectiveness implementation trial; experience; health care service organization; innovation; medical specialties; meetings; member; multi-site trial; opioid use; opioid use disorder; point of care; practice setting; prescription monitoring program; programs; prospective; racial diversity; recruit; research study; retention rate; statistics; stimulant use; stimulant use disorder; substance misuse; substance use; support tools; treatment program; trend; validation studies

Project Summary (Abstract): Since its establishment in 2000, the Ohio Valley Node (OVN) has been one of the most productive of NIDA's Clinical Trials Network (CTN) nodes, both in leading and participating in multi-site trials. The OVN includes successful partnerships with four healthcare systems, two pharmacy networks, and six addiction specialty/ infectious disease programs. These collaborating sites span a seven-state region including some of the states most heavily impacted by opioid (Ohio, Kentucky, and West Virginia) and methamphetamine (Missouri, Kentucky, and North Dakota) use. The OVN includes Midwestern, Appalachian, Upper South, and Native American representation, which significantly enhances the geographical and cultural diversity of the CTN. The OVN Research Core is the driving force of the OVN and is led by Dr. Winhusen, one of the foremost experts in conducting multi-site addiction clinical trials in clinical practice settings. The OVN investigators have extensive expertise in substance use disorders (Winhusen, Brown, Burlew, Lyons, Montgomery, Lofwall, Walsh) and bioinformatics (Kaelber, Xu). The six members of the OVN research-implementation team bring > 60 years of combined experience conducting CTN clinical trials. If funded, our overall goal would be to utilize the wealth of experience and expertise gained over the past 19 years to conduct the research needed to address public health care crises, including the opioid use epidemic and the alarming increase in stimulant use. To this end, we would work with our healthcare partners to engage a diverse set of patients and service systems in areas highly impacted by substance use in CTN research. We would also contribute our expertise in conducting efficacy, effectiveness, and implementation trials testing the full range of interventions, from medications to behavioral interventions and health service innovations, for both opioid and stimulant use disorders. Moreover, we would contribute our expertise in the use of electronic health records for prospective and retrospective research studies, including the application of artificial intelligence to large healthcare datasets. In sum, we seek to continue providing scientific leadership, particularly on studies that could meaningfully impact clinical practice, and to effectively collaborate with a variety of professionals including treatment providers, investigators from diverse institutions, and staff of the Center for CTN (CCTN), clinical coordinating center (CCC) and data and statistics center (DSC) in support of the CTN mission.

项目摘要（Abstract）： 自2000年成立以来，俄亥俄州山谷节点（OVN）一直是NIDA最富有成效的项目之一。 临床试验网络（CTN）节点，领导和参与多中心试验。OVN包括 与四个医疗保健系统、两个药房网络和六个成瘾专业/ 传染病项目。这些合作地点跨越七个州的地区，其中包括一些州 受阿片类药物（俄亥俄州、肯塔基州和西弗吉尼亚州）和甲基苯丙胺（密苏里州， 肯塔基州和北达科他州）使用。OVN包括中西部，阿巴拉契亚，上南部和本地 美国的代表性，这大大增强了CTN的地理和文化多样性。的 OVN研究核心是OVN的驱动力，由Winhusen博士领导，他是OVN领域最重要的专家之一。 在临床实践环境中开展多地点成瘾临床试验。OVN调查人员有广泛的 物质使用障碍方面的专业知识（Winhusen、Brown、Burlew、里昂、蒙哥马利、Lofwall、沃尔什），以及 生物信息学（Kaelber，Xu）。OVN研究实施团队的六名成员带来了超过60年的经验， 结合开展CTN临床试验的经验。如果得到资助，我们的总体目标将是利用 在过去19年中获得的经验和专业知识，以进行所需的研究，以解决公众 卫生保健危机，包括类阿片使用流行和兴奋剂使用惊人增加。为此目的， 我们将与我们的医疗保健合作伙伴合作，让不同领域的患者和服务系统参与进来， 在CTN研究中受到物质使用的高度影响。我们还将贡献我们的专业知识， 有效性，有效性和实施试验，测试从药物到 行为干预和卫生服务创新，用于阿片类药物和兴奋剂使用障碍。此外，委员会认为， 我们将贡献我们在使用电子健康记录方面的专业知识， 研究，包括人工智能在大型医疗数据集上的应用。总而言之，我们寻求 继续提供科学领导，特别是在可能对临床产生有意义影响的研究方面 实践，并与包括治疗提供者在内的各种专业人员有效合作， 来自不同机构的研究者和CTN中心（CCTN）的工作人员，临床协调中心 (CCC)以及数据和统计中心（DSC），以支持CTN使命。