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Mapping Stomach Autonomic Circuitry and Function for Neuromodulation of Gastric Disorders

绘制胃自主神经回路和功能以调节胃部疾病的神经调节

基本信息

批准号：
10445450
负责人：
TERRY L. POWLEY
金额：
$ 348.81万
依托单位：
PURDUE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-24 至 2022-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10445450
关键词：
Mapping Stomach Autonomic Circuitry Function

项目摘要

Project Summary Two series of complementary experiments, conducted by our exceptionally qualified team of 11 investigators from eight state-of-the-art laboratories at four institutions, will close critical gaps in the current characterization of the autonomic connectome controlling stomach function. These proposed synergistic anatomical and functional investigations will form the needed foundation for neuromodulation protocols that can correct shortcomings in past, first-generation bioelectronic attempts to ameliorate and monitor gastric disorders. Building on recent advances in mapping of vagal circuits, many reported by our research team, SA 1 will finish inventories of the efferent and afferent terminal phenotypes, analyze their collateral specializations, establish their regional distributions, and identify chemical taxonomies of their target tissues. We will also compare the neural circuitry of the human (and pig, an ideal large animal preclinical proof-of-principle model) stomach with that of the rat model to facilitate future translational extrapolations. The analyses of SA 1 will use a suite of high-definition neural tracing, immunohistochemical and molecular protocols, along with advanced imaging and morphometric techniques, that our team has adapted to autonomic circuits. SA 1 will focus on those elements in gastric neural network that may be most relevant to informing SA 2 and identify additional localized sites in the stomach wall where focal stimulation will have strong therapeutic potential. In functional assessments, SA 2 will identify optimal locations for both highly selective vagal stimulation (VNS) and precise surgical placement between the exit of the vagus from the brainstem and the target sites of the axons within the stomach wall and will determine the best stimulation protocols for augmenting gastric physiology. SA 2 will use state-of-the-art closed-loop stimulator technologies, algorithms, and electrodes (previously designed and robustly proven by investigators on our research team) and assess the reliability, validity, and stability of the VNS by employing a battery (≥ 6) of acute, short-term, and long-term non-invasive endpoints. The team will use data archiving and resource sharing platforms that are universally accessible to all research and medical communities.

项目总结

项目成果

期刊论文数量（32）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Overview of Flow Cytometry and Microbiology.

DOI：
10.1002/cpcy.37
发表时间：
2018-04-01
期刊：
Current protocols in cytometry
影响因子：
0
作者：
Robinson, J Paul
通讯作者：
Robinson, J Paul

Acute effects of vagus nerve stimulation parameters on gastric motility assessed with magnetic resonance imaging.

DOI：
10.1111/nmo.13853
发表时间：
2020-07
期刊：
Neurogastroenterology and motility
影响因子：
3.5
作者：
Lu KH;Cao J;Phillips R;Powley TL;Liu Z
通讯作者：
Liu Z

Chronic cuffing of cervical vagus nerve inhibits efferent fiber integrity in rat model.

DOI：
10.1088/1741-2552/aaa039
发表时间：
2018-06
期刊：
Journal of neural engineering
影响因子：
4
作者：
Somann JP;Albors GO;Neihouser KV;Lu KH;Liu Z;Ward MP;Durkes A;Robinson JP;Powley TL;Irazoqui PP
通讯作者：
Irazoqui PP

Contrast-Enhanced Magnetic Resonance Imaging of Gastric Emptying and Motility in Rats.