Mapping Stomach Autonomic Circuitry and Function for Neuromodulation of Gastric Disorders

绘制胃自主神经回路和功能以调节胃部疾病的神经调节

基本信息

  • 批准号:
    9286967
  • 负责人:
  • 金额:
    $ 200.44万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-09-24 至 2022-12-31
  • 项目状态:
    已结题

项目摘要

Project Summary Two series of complementary experiments, conducted by our exceptionally qualified team of 11 investigators from eight state-of-the-art laboratories at four institutions, will close critical gaps in the current characterization of the autonomic connectome controlling stomach function. These proposed synergistic anatomical and functional investigations will form the needed foundation for neuromodulation protocols that can correct shortcomings in past, first-generation bioelectronic attempts to ameliorate and monitor gastric disorders. Building on recent advances in mapping of vagal circuits, many reported by our research team, SA 1 will finish inventories of the efferent and afferent terminal phenotypes, analyze their collateral specializations, establish their regional distributions, and identify chemical taxonomies of their target tissues. We will also compare the neural circuitry of the human (and pig, an ideal large animal preclinical proof-of-principle model) stomach with that of the rat model to facilitate future translational extrapolations. The analyses of SA 1 will use a suite of high-definition neural tracing, immunohistochemical and molecular protocols, along with advanced imaging and morphometric techniques, that our team has adapted to autonomic circuits. SA 1 will focus on those elements in gastric neural network that may be most relevant to informing SA 2 and identify additional localized sites in the stomach wall where focal stimulation will have strong therapeutic potential. In functional assessments, SA 2 will identify optimal locations for both highly selective vagal stimulation (VNS) and precise surgical placement between the exit of the vagus from the brainstem and the target sites of the axons within the stomach wall and will determine the best stimulation protocols for augmenting gastric physiology. SA 2 will use state-of-the-art closed-loop stimulator technologies, algorithms, and electrodes (previously designed and robustly proven by investigators on our research team) and assess the reliability, validity, and stability of the VNS by employing a battery (≥ 6) of acute, short-term, and long-term non-invasive endpoints. The team will use data archiving and resource sharing platforms that are universally accessible to all research and medical communities.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

TERRY L. POWLEY其他文献

TERRY L. POWLEY的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('TERRY L. POWLEY', 18)}}的其他基金

Mapping Stomach Autonomic Circuitry and Function for Neuromodulation of Gastric Disorders
绘制胃自主神经回路和功能以调节胃部疾病的神经调节
  • 批准号:
    10216768
  • 财政年份:
    2016
  • 资助金额:
    $ 200.44万
  • 项目类别:
Mapping Stomach Autonomic Circuitry and Function for Neuromodulation of Gastric Disorders
绘制胃自主神经回路和功能以调节胃部疾病的神经调节
  • 批准号:
    10445450
  • 财政年份:
    2016
  • 资助金额:
    $ 200.44万
  • 项目类别:
Mapping Stomach Autonomic Circuitry and Function for Neuromodulation of Gastric Disorders
绘制胃自主神经回路和功能以调节胃部疾病的神经调节
  • 批准号:
    9500389
  • 财政年份:
    2016
  • 资助金额:
    $ 200.44万
  • 项目类别:
Gastrointestinal Tract Innervation: Patterns of Aging
胃肠道神经支配:衰老模式
  • 批准号:
    8009573
  • 财政年份:
    2010
  • 资助金额:
    $ 200.44万
  • 项目类别:
Autonomic Control of Body Weight and Feeding
体重和进食的自主控制
  • 批准号:
    8006874
  • 财政年份:
    2010
  • 资助金额:
    $ 200.44万
  • 项目类别:
GASTROINTESTINAL NUTRIENT SIGNALS CONTROLLING INGESTION
控制摄入的胃肠营养信号
  • 批准号:
    7877745
  • 财政年份:
    2009
  • 资助金额:
    $ 200.44万
  • 项目类别:
GASTROINTESTINAL NIUTRIENT SIGNALS CONTROLLING INGESTION
控制摄入的胃肠道营养信号
  • 批准号:
    7699724
  • 财政年份:
    2008
  • 资助金额:
    $ 200.44万
  • 项目类别:
THE ANALYTICAL CORE
分析核心
  • 批准号:
    7699730
  • 财政年份:
    2008
  • 资助金额:
    $ 200.44万
  • 项目类别:
Gastrointestinal Nutrient Signals Controlling Ingestion
控制摄入的胃肠营养信号
  • 批准号:
    7300554
  • 财政年份:
    2007
  • 资助金额:
    $ 200.44万
  • 项目类别:
Gastrointestinal Tract Innervation: Patterns of Aging
胃肠道神经支配:衰老模式
  • 批准号:
    7456081
  • 财政年份:
    2002
  • 资助金额:
    $ 200.44万
  • 项目类别:

相似海外基金

Acute senescence: a novel host defence counteracting typhoidal Salmonella
急性衰老:对抗伤寒沙门氏菌的新型宿主防御
  • 批准号:
    MR/X02329X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 200.44万
  • 项目类别:
    Fellowship
Transcriptional assessment of haematopoietic differentiation to risk-stratify acute lymphoblastic leukaemia
造血分化的转录评估对急性淋巴细胞白血病的风险分层
  • 批准号:
    MR/Y009568/1
  • 财政年份:
    2024
  • 资助金额:
    $ 200.44万
  • 项目类别:
    Fellowship
Combining two unique AI platforms for the discovery of novel genetic therapeutic targets & preclinical validation of synthetic biomolecules to treat Acute myeloid leukaemia (AML).
结合两个独特的人工智能平台来发现新的基因治疗靶点
  • 批准号:
    10090332
  • 财政年份:
    2024
  • 资助金额:
    $ 200.44万
  • 项目类别:
    Collaborative R&D
Cellular Neuroinflammation in Acute Brain Injury
急性脑损伤中的细胞神经炎症
  • 批准号:
    MR/X021882/1
  • 财政年份:
    2024
  • 资助金额:
    $ 200.44万
  • 项目类别:
    Research Grant
KAT2A PROTACs targetting the differentiation of blasts and leukemic stem cells for the treatment of Acute Myeloid Leukaemia
KAT2A PROTAC 靶向原始细胞和白血病干细胞的分化,用于治疗急性髓系白血病
  • 批准号:
    MR/X029557/1
  • 财政年份:
    2024
  • 资助金额:
    $ 200.44万
  • 项目类别:
    Research Grant
Combining Mechanistic Modelling with Machine Learning for Diagnosis of Acute Respiratory Distress Syndrome
机械建模与机器学习相结合诊断急性呼吸窘迫综合征
  • 批准号:
    EP/Y003527/1
  • 财政年份:
    2024
  • 资助金额:
    $ 200.44万
  • 项目类别:
    Research Grant
FITEAML: Functional Interrogation of Transposable Elements in Acute Myeloid Leukaemia
FITEAML:急性髓系白血病转座元件的功能研究
  • 批准号:
    EP/Y030338/1
  • 财政年份:
    2024
  • 资助金额:
    $ 200.44万
  • 项目类别:
    Research Grant
STTR Phase I: Non-invasive focused ultrasound treatment to modulate the immune system for acute and chronic kidney rejection
STTR 第一期:非侵入性聚焦超声治疗调节免疫系统以治疗急性和慢性肾排斥
  • 批准号:
    2312694
  • 财政年份:
    2024
  • 资助金额:
    $ 200.44万
  • 项目类别:
    Standard Grant
ロボット支援肝切除術は真に低侵襲なのか?acute phaseに着目して
机器人辅助肝切除术真的是微创吗?
  • 批准号:
    24K19395
  • 财政年份:
    2024
  • 资助金额:
    $ 200.44万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Collaborative Research: Changes and Impact of Right Ventricle Viscoelasticity Under Acute Stress and Chronic Pulmonary Hypertension
合作研究:急性应激和慢性肺动脉高压下右心室粘弹性的变化和影响
  • 批准号:
    2244994
  • 财政年份:
    2023
  • 资助金额:
    $ 200.44万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了