A Text-Based Adherence Game for Young People Living with HIV in Ghana

针对加纳艾滋病毒感染者的基于文本的遵守游戏

基本信息

批准号：
10441361
负责人：
Nicholas Tarantino
金额：
$ 17.53万
依托单位：
RHODE ISLAND HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10441361
关键词：
Achievement Acquired Immunodeficiency Syndrome Address Adherence Adolescent and Young Adult Adult Africa South of the Sahara African Area Belief CD4 Lymphocyte Count Car Phone Caring Cellular Phone Childhood Clinic Clinical Clinical Psychology Cognitive Community Psychology Consult Consultations Counseling Country Coupled Data Development Drops Educational workshop Elements Face Failure Foundations Ghana Goals HIV HIV Infections Health Health Promotion Health Services Accessibility Healthcare Hospitals Infection Internet Intervention Intervention Trial Interview K-Series Research Career Programs Knowledge Life Medical Mentors Mentorship Methodology Modernization Outcome Patients Persons Phase Public Health Qualitative Methods Randomized Reading Research Research Personnel Resource-limited setting Rhode Island Risk Sahara Sampling Scientist Self Management Services Sex Behavior Social Interaction Social support Technical Expertise Testing Text Text Messaging Time Training Training Support United States Universities Viral Viral Load result Vulnerable Populations Work Youth age group antiretroviral therapy base behavioral adherence biobehavior care outcomes career cost design emerging adult experience global health high risk improved innovation mHealth medical schools middle age mobile application novel preference prevent prototype skills social standard of care substance use symposium theories therapy adherence therapy development transmission process two way texting young adult

项目摘要

PROJECT SUMMARY Maintaining adherence to HIV treatment is a challenge and nonadherence is associated with heightened risks for secondary HIV transmission and poor health outcomes. In sub-Saharan Africa, an estimated one in three patients do not take antiretroviral therapy (ART) as prescribed and one in four disengage from treatment within a year of initiating ART. Adherence to care outcomes are even worse among older adolescents and young adults (young people) living with HIV (YPLH) who experience the highest rates of ART nonadherence, treatment attrition, and virologic failure compared to other age groups. Consistent with the Division of AIDS Research’s areas of High Priority, the current project targets YPLH using a novel mHealth gaming intervention in order to promote their adherence to HIV care. Candidate: The candidate is a clinical scientist with a background in clinical and community psychology. His prior research focuses on the development of interventions to prevent HIV infection among underserved youth, primarily in the United States (U.S.). He is applying for a five-year K23 Career Development Award in order to expand his expertise and support his training, mentorship, and research within a novel area of intervention in a sub-Sahara African country (Ghana). Mentoring: Six well-established researchers serve as mentors on this proposal. Each brings complimentary expertise consistent with the study’s aims and training objectives. Dr. Larry Brown is the Primary Mentor and has experience in creating mobile gaming interventions for YPLH in the U.S. Four other mentors are HIV-focused investigators with expertise in global health research (Dr. Matthew Mimiaga), studies in Ghana (Drs. Awewura Kwara and Margaret Lartey), and applied qualitative methods (Dr. Kate Guthrie). Dr. Beth Bock is an expert in mHealth interventions including the use of text messages to address substance use. Research: The aims of the proposed project are to (1) gather information on the barriers and facilitators to adherence to care among YPLH attending an HIV clinic in Ghana and gauge YPLH preferences for an mHealth intervention via in-depth interviews with YPLH , their treatment buddies, and clinic staff; (2) develop a Text- Based Adherence Game to promote adherence to care by consulting with an mHealth developer and conducting an iterative open trial of the intervention with YPLH (n = 24); and (3) evaluate the intervention for feasibility and preliminary efficacy with a small randomized pilot examining biobehavioral adherence outcomes over one year in a sample of YPLH who receive the Text-Based Adherence Game versus YPLH who receive the standard of care (n = 60). Training: Specific training overseen by the mentorship team through formal coursework, workshops, seminars, conferences, directed readings, clinical work, and mentored experiences will be received by the candidate. Areas of focus include HIV-focused research in sub-Saharan Africa, broadly, and in Ghana, specifically; methodological and technical mHealth skills; and knowledge of gamification. The candidate is institutionally supported by Rhode Island Hospital and the Alpert Medical School of Brown University.

项目摘要保持遵守艾滋病毒治疗是一个挑战，不遵守与风险增加有关用于继发HIV传播和健康状况不佳。在撒哈拉以南非洲，估计三分之一患者不接受处方的抗逆转录病毒疗法（ART），四分之一的脱离治疗在发起艺术的一年之内。在年长的青少年中，遵守护理结果甚至更糟患有艾滋病毒（yplh）的年轻人（年轻人），经历了最高的艺术不遵守率，与其他年龄组相比，治疗属性和病毒衰竭。与艾滋病的划分一致研究的优先级高，目前的项目使用新型的MHealth游戏干预措施针对YPLH 为了促进他们遵守艾滋病毒护理。候选人：候选人是一名临床科学家临床和社区心理学背景。他的先前研究重点是发展预防服务不足的年轻人的干预措施，主要在美国（美国）。他是申请五年K23职业发展奖，以扩大他的专业知识并支持他的在撒哈拉以南非洲国家的新型干预领域内的培训，精神训练和研究（加纳）。指导：六名成熟的研究人员是该建议的指导者。每个带来免费专业知识与研究的目标和培训目标一致。拉里·布朗博士是主要导师，并具有在美国为YPLH创建移动游戏干预措施的经验导师是具有全球健康研究专业知识（Matthew Mimiaga博士）专业知识的艾滋病毒研究人员，研究在加纳（Awewura Kwara和Margaret Lartey博士），并应用定性方法（Kate Guthrie博士）。博士贝丝·博克（Beth Bock）是MHealth干预措施的专家，包括使用短信来解决使用物质的使用。研究：拟议项目的目的是（1）收集有关障碍和促进者的信息在加纳的HIV诊所和MHealth的YPLH诊所的YPLH遵守YPLH中的遵守通过与YPLH的深入访谈，他们的治疗伙伴和诊所工作人员进行干预；（2）开发文字 - 基于依从性游戏通过与MHealth开发人员进行咨询并进行咨询来促进遵守护理对YPLH干预的迭代开放试验（n = 24）；（3）评估可行性的干预措施和初步的效率，一个小的随机飞行员检查了生物行为的依从性结果在获得基于文本的依从性游戏的YPLH样本中与获得标准的YPLH的一年护理（n = 60）。培训：由Mentalship团队通过正式课程负责的特定培训，将会收到讲习班，半手，会议，定向阅读，临床工作和修改经验由候选人。重点领域包括在撒哈拉以南非洲，广泛的艾滋病毒研究和加纳的研究具体来说;方法和技术MHealth技能；和游戏化知识。候选人是由罗德岛医院和布朗大学的Alpert医学院的机构支持。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Correction to: A Review of Interventions to Enhance HIV Medication Adherence.

更正：增强艾滋病毒药物依从性的干预措施回顾。

DOI：
10.1007/s11904-021-00573-y
发表时间：
2021
期刊：
Current HIV/AIDS reports
影响因子：
4.6
作者：
Whiteley,LauraB;Olsen,ElizabethM;Haubrick,KaylaK;Odoom,Enyonam;Tarantino,Nicholas;Brown,LarryK
通讯作者：
Brown,LarryK

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