Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN)Scientific Leadership Center; ADMIN SUPPLEMENT

艾滋病毒/艾滋病干预青少年医学试验网络 (ATN) 科学领导中心；

• 批准号: 10855435
• 负责人: Lisa B Hightow-Weidman
• 金额: $ 195.49万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-05 至 2029-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10855435
• 关键词: AIDS prevention; Achievement; Acquired Immunodeficiency Syndrome; Address; Administrative Supplement; Adolescence; Adolescent; Adolescent Medicine Trials Network; Adolescent and Young Adult; Age; Alcohol consumption; Area; Award; Budgets; Caring; Clinical Research; Clinical Trials; Collaborations; Communication; Communities; Complex; Consultations; Continuity of Patient Care; Development; Dissemination and Implementation; Elements; Emotional; Enrollment; Ensure; Epidemic; Evolution; Friends; Funding; Goals; Growth; HIV; HIV Infections; HIV Seronegativity; HIV prevention trials network; HIV/AIDS; HIV/STD; Individual; Infection; Infrastructure; Intervention; Leadership; Mental Health; Mission; Monitor; Neurocognitive; Oils; Ownership; Parents; Pharmaceutical Preparations; Phase; Population; Poverty; Prevalence; Prevention; Productivity; Protocols documentation; Qualifying; Research; Research Priority; Research Support; Resources; Science; Site; Social Change; Structure; Substance abuse problem; System; Talents; United States; United States National Institutes of Health; Violence; Viral; Vision; Work; Youth; adolescent HIV prevention; adolescent health outcomes; age group; career; clinical research site; community-level factor; cost; design; electronic consent; evidence base; experience; improved; innovation; insight; medical appointment; member; multidisciplinary; operation; participant retention; participant safety; pharmacovigilance; pre-exposure prophylaxis; programs; racism; recruit; resilience; social media; social stigma; uptake; web site; young adult

The scientific rationale for this supplement is to support the Adolescent Medicine Trials Network for HIV Interventions (ATN) mission and overall aims. These supplemental funds are needed to cover unanticipated costs that were not budgeted in either the original Scientific Leadership Center (SLC) application (RFA-HD-23- 020) or the Operations and Collaborations Center (OCC) application (RFA-HD-23-021) but are critical to the successful execution of the ATN goals. All funds requested support core needs and gaps identified through collaborative consultation with members of the SLC, OCC and NIH and are for activities that are within the scope of the originally reviewed and awarded application. Based on our detailed review of the parent RFAs, we anticipated that all of these activities would have been included in the application put forth by the OCC. However, now that the network has launched, we have found that these critical gaps exist and re-budgeting from the prime award to cover these costs is not an option because all the awarded funds are obligated. Specific Aim 1: Advance a rigorous and innovative research agenda to end the HIV epidemic among adolescents and young adults (ages 13-24) in the US by establishing a robust ATN infrastructure that prioritizes and implements high-impact research. The administrative supplement will support research gaps in current ATN agenda, specifically addressing HIV prevention and care needs among youth impacted by alcohol use and aligning one of the currently supported protocols with a collaborative protocol in the HIV Prevention Trials Network (HPTN). Further, the supplement supports important aspects of successful research implementation, including enrollment and retention of participants through social media and eConsent and critical aspects of monitoring participant safety and pharmacovigilance. Specific Aim 2: Facilitate internal communication and external collaborations and idea exchange to optimize alignment with NIH priorities, address emergent opportunities and maximize network productivity and resources. The administrative supplement will support successful implementation and dissemination of ATN protocols. While the OCC is developing the ATN website, they do not have the capacity or expertise to create any recruitment/dissemination materials to be displayed on the website nor have they planned for any dissemination activities at the site level. Specific Aim 3: Develop and nurture partnerships that will ensure community and youth input at all stages of conceptualization, design, implementation, and interpretation of the research. The administrative supplement will support adequate representation of youth within the ATN. The Subject Matter Research Consultants (SMRC) are a core facet of the ATN and are being deeply embedded into all aspects of the project including as members of protocol teams, scientific leadership groups, and Communication and Dissemination Hub where they will provide ongoing consultation.

这一补充的科学依据是支持艾滋病毒的青少年医学试验网络 干预（ATN）的使命和总体目标。这些补充资金需要支付意外的 在最初的科学领导中心（SLC）申请中没有预算的费用（RFA-HD-23- 020)或运营与协作中心（OCC）应用程序（RFA-HD-23-021），但对 成功实现ATN目标。所要求的所有资金都用于支持通过以下途径查明的核心需求和差距： 与SLC，OCC和NIH成员的合作磋商，并用于在 最初审查和授予申请的范围。根据我们对父RFA的详细审查，我们 预计所有这些活动都将包括在OCC提出的申请中。 然而，现在网络已经启动，我们发现这些关键的差距存在，并重新预算 从主合同中提取资金来支付这些费用是不可行的，因为所有的合同资金都是有义务的。 具体目标1：推进严格和创新的研究议程，以结束艾滋病毒的流行， 青少年和年轻人（13-24岁）在美国通过建立一个强大的ATN基础设施， 优先考虑并实施高影响力的研究。行政补充将支持研究 目前的扶贫网络议程中的差距，特别是解决受艾滋病毒影响的青年的艾滋病毒预防和护理需求 酒精使用和调整目前支持的协议之一，在艾滋病毒的合作协议， 预防试验网络。此外，该补充支持成功研究的重要方面 实施，包括通过社交媒体和eConsent招募和保留参与者， 监测受试者安全性和药物警戒的关键方面。具体目标2：促进内部 沟通和外部合作以及思想交流，以优化与NIH的一致性 优先级，解决紧急机会，最大限度地提高网络生产力和资源。的 行政补充将支持ATN协议的成功实施和传播。而 OCC正在开发ATN网站，他们没有能力或专业知识来创建任何 他们没有计划在网站上展示任何招聘/宣传材料，也没有计划在网站上展示任何招聘/宣传材料。 现场一级的传播活动。具体目标3：发展和培育伙伴关系， 社区和青年在概念化、设计、实施和 研究的解释。行政补编将支持青年的充分代表性 在ATN。主题研究顾问（SMRC）是ATN的核心方面， 深入到项目的各个方面，包括作为协议团队的成员，科学领导 他们将在该中心提供持续的咨询。