Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN)Scientific Leadership Center; ADMIN SUPPLEMENT

这份附录的科学基础是支持青少年艾滋病药物试验网络 干预措施(ATN)的任务和总体目标。这些补充资金需要用来支付意外费用。 原始科学领导中心(SLC)应用程序(RFA-HD-23- 020)或运营与协作中心(OCC)应用程序(RFA-HD-23-021)，但对于 ATN目标的成功执行。请拨的所有资金用于支持通过以下方式确定的核心需求和差距 与SLC、OCC和NIH成员进行协作协商，并在 原审定申请的范围。根据我们对家长财务报告的详细审查，我们 预计所有这些活动都将包括在OCC提出的申请中。 然而，现在网络已经启动，我们发现这些关键差距存在并重新编制预算 从主要奖励中支付这些费用不是一种选择，因为所有奖励的资金都是债务。 具体目标1：推动一项严谨和创新的研究议程，在以下方面结束艾滋病毒流行 美国青少年和青壮年(13-24岁)通过建立强大的ATN基础设施 优先安排和实施高影响力的研究。行政副刊将支持研究 当前ATN议程中的差距，特别是解决受以下影响的青年中的艾滋病毒预防和护理需求 酒精使用和使目前支持的方案之一与艾滋病毒的合作方案相一致 预防试验网络(HPTN)。此外，本补编还支持成功研究的重要方面。 实施，包括通过社交媒体和电子会议注册和保留参与者以及 监测参与者安全和药物警戒的关键方面。具体目标2：促进内部 沟通、外部协作和思想交流，以优化与NIH的合作 优先事项，处理紧急机会，最大限度地提高网络生产力和资源。这个 行政补充将支持ATN议定书的成功实施和传播。而当 OCC正在开发ATN网站，他们没有能力或专业知识来创建任何 招聘/传播材料将在网站上展示，他们也没有计划 现场一级的传播活动。具体目标3：发展和培育伙伴关系，以确保 社区和青年在概念化、设计、实施和 对研究的解释。行政补编将支持青年的适当代表性。 在ATN内。主题研究顾问(SMRC)是ATN的一个核心方面，并且正在 深入到项目的各个方面，包括作为礼宾团队的成员、科学领导 小组，以及传播和传播中心，他们将在那里提供持续的咨询。

The scientific rationale for this supplement is to support the Adolescent Medicine Trials Network for HIV Interventions (ATN) mission and overall aims. These supplemental funds are needed to cover unanticipated costs that were not budgeted in either the original Scientific Leadership Center (SLC) application (RFA-HD-23- 020) or the Operations and Collaborations Center (OCC) application (RFA-HD-23-021) but are critical to the successful execution of the ATN goals. All funds requested support core needs and gaps identified through collaborative consultation with members of the SLC, OCC and NIH and are for activities that are within the scope of the originally reviewed and awarded application. Based on our detailed review of the parent RFAs, we anticipated that all of these activities would have been included in the application put forth by the OCC. However, now that the network has launched, we have found that these critical gaps exist and re-budgeting from the prime award to cover these costs is not an option because all the awarded funds are obligated. Specific Aim 1: Advance a rigorous and innovative research agenda to end the HIV epidemic among adolescents and young adults (ages 13-24) in the US by establishing a robust ATN infrastructure that prioritizes and implements high-impact research. The administrative supplement will support research gaps in current ATN agenda, specifically addressing HIV prevention and care needs among youth impacted by alcohol use and aligning one of the currently supported protocols with a collaborative protocol in the HIV Prevention Trials Network (HPTN). Further, the supplement supports important aspects of successful research implementation, including enrollment and retention of participants through social media and eConsent and critical aspects of monitoring participant safety and pharmacovigilance. Specific Aim 2: Facilitate internal communication and external collaborations and idea exchange to optimize alignment with NIH priorities, address emergent opportunities and maximize network productivity and resources. The administrative supplement will support successful implementation and dissemination of ATN protocols. While the OCC is developing the ATN website, they do not have the capacity or expertise to create any recruitment/dissemination materials to be displayed on the website nor have they planned for any dissemination activities at the site level. Specific Aim 3: Develop and nurture partnerships that will ensure community and youth input at all stages of conceptualization, design, implementation, and interpretation of the research. The administrative supplement will support adequate representation of youth within the ATN. The Subject Matter Research Consultants (SMRC) are a core facet of the ATN and are being deeply embedded into all aspects of the project including as members of protocol teams, scientific leadership groups, and Communication and Dissemination Hub where they will provide ongoing consultation.