Piriform cortex: sequential developmental events
梨状皮层:顺序发育事件
基本信息
- 批准号:10442245
- 负责人:
- 金额:$ 41.88万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-12-01 至 2027-03-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAfferent NeuronsAnteriorArchitectureAttentionAxonBrainCellsCiliaClustered Regularly Interspaced Short Palindromic RepeatsCodeComplexContralateralDataDevelopmentDidelphidaeElectroporationEpithelialEventFOXP2 geneFoundationsGangliaGeneticGoalsInterneuronsIpsilateralKnock-outKnowledgeLateralLens developmentLigand BindingMapsMethodsMolecularMolecular GeneticsMusNeocortexNeurogliaNeuronsOdorant ReceptorsOdorsOlfactory EpitheliumOlfactory PathwaysOlfactory tractPlayPropertyRadialRattusRecurrenceResolutionRoleSOX5 geneSeminalSmell PerceptionSpecificityStructureStudy modelsSurfaceSynapsesTestingTimeLineWorkanterior commissureassociation cortexconnectomecourse developmentexhaustionhippocampal pyramidal neuronin uteroinnovationinsightmigrationneocorticalnerve supplyneural circuitneuroblastneurogenesisnovelolfactory bulbolfactory bulb glomeruliolfactory sensory neuronspiriform cortexreceptorsegregationsensory systemspatiotemporaltooltranscription factor
项目摘要
Project Summary – Abstract
The perception of odors begins in the olfactory epithelium when odorant ligands bind to molecular
receptors expressed on the cilia of the olfactory sensory neurons, each of which expresses only 1 of ~1200
candidate receptors. As the sensory neuron axons exit the epithelium they progress over the surface of
the olfactory bulb and all of the axons coming from neurons expressing the same odorant receptor
converge into only 2/3 glomeruli/olfactory bulb. However, the convergence and discrete circuitry of the
olfactory bulb is not apparent in piriform cortex (PCX), at least grossly. Afferent projections to piriform
appear divergent and broadly distributed. Moreover, in contrast to the more widely studied neocortex, the
3-layer piriform paleocortex does not exhibit a definitive columnar structure, leaving open the question of
whether principles learned from neocortex can be applied to understanding piriform. Most of what we
know of the neuronal and synaptic organization of piriform has come from early studies of rat and opossum,
that while important did not benefit from contemporary genetic and molecular tools. The mouse, which
has emerged as the dominant mammalian model for studies of the olfactory epithelium and bulb, has
benefited immeasurably from these new tools. However, there are few examples of the application of
contemporary genetic and molecular methods to studies of mouse piriform cortex. We remain woefully
ignorant of the most fundamental features of mouse piriform cortex When do synapses first appear in
mouse PCX and when do they achieve laminar segregation? What is the organization of the ipsi- and
contralateral association axons that likely contribute to the cortical coding of odors in ensembles of
neurons? What are the molecular mechanisms/transcription factors underlying the fate and specificity of
PCX neurons/structure? To begin addressing these significant gaps in our knowledge we are proposing 3
specific aims: Aim 1 addresses the emergence of synaptic circuits in PCX and tests the hypothesis that
it occurs in a spatio-temporal format that distinguishes the laminar specificity of circuits. Aim 2 addresses
the PCX associational connectome, both ipsilateral and contralateral via the anterior commissure. Aim 3
tests the spatiotemporal expression of transcription factors (TFs) that we hypothesize are important in
establishing PCX pyramidal neuron identity and contributions to the association axon network in PCX.
Selective TFs will be knocked out using CRISPR to determine their role at a more granular level.
Collectively these innovative studies will provide new insight into the mechanisms regulating the
organization of PCX and the foundations of odor coding in PCX.
项目摘要-摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Charles A Greer其他文献
Charles A Greer的其他文献
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{{ truncateString('Charles A Greer', 18)}}的其他基金
Dynamic interactions among olfactory sensory neuron axons
嗅觉感觉神经元轴突之间的动态相互作用
- 批准号:
10224737 - 财政年份:2019
- 资助金额:
$ 41.88万 - 项目类别:
Dynamic interactions among olfactory sensory neuron axons
嗅觉感觉神经元轴突之间的动态相互作用
- 批准号:
10685631 - 财政年份:2019
- 资助金额:
$ 41.88万 - 项目类别:
Piriform cortex: sequential developmental events
梨状皮层:顺序发育事件
- 批准号:
10589155 - 财政年份:2014
- 资助金额:
$ 41.88万 - 项目类别:
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