Amazonian Center of Excellence in Malaria Research

亚马逊疟疾研究卓越中心

• 批准号: 10441614
• 负责人: MARCIA C. CASTRO
• 金额: $ 23.19万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10441614
• 关键词: Bioinformatics; Biometry; Biostatistics Core; Brazil; Computer Security; Computer software; Computers; Core Facility; Data; Data Analyses; Data Collection; Databases; Deposition; Dictionary; Ensure; Entomology; Future; Genbank; Genetic; Genomics; Human Resources; Information Technology; Infrastructure; Institutes; Institution; Malaria; Metadata; Modeling; Modification; Participant; Peru; Peruvian; Preparation; Protocols documentation; Reporting; Research; Research Design; Research Personnel; Resource Sharing; Resources; Role; Secure; Services; Site; Standardization; Statistical Data Interpretation; Structure; Surveys; Tablets; Techniques; Time; Training; Universities; Work; base; cost; data management; data quality; data standards; longitudinal dataset; programs; public repository; skills; statistics

Data Management and Biostatistics Core - Core Leader: Dr. Marcia C. Castro, HSPH ABSTRACT The Data Management and Biostatistics Core will provide comprehensive data management and statistical support for all Projects of the Amazonia ICEMR Program. Its functions include: guide study design; develop study protocols and metadata; ensure proper and safe data collection, management, and sharing; generate simple tabulations routinely and as requested by Project leaders; provide training as needed; and assist with statistical analysis. The Core will be instituted at Harvard University, integrated with the existing infrastructure of the partner institutions, and will work in seamless integration with Project leaders and researchers in study sites. The Core Leader will be Dr. Castro, directly supported by a part-time data manager & programmer based at Harvard, and by full-time data managers available in Peru and Brazil. Levering resources freely available to Harvard personnel, and thus at no cost to the ICEMR project, the Core will benefit from a network of consultants that offer high quality services on survey planning, biostatistics, geospatial modeling, and bioinformatics. Specifically, the Core will create/organize longitudinal datasets, accompanied by dictionaries and metadata, of all survey data previously collected in Peru and Brazil during the 2010-2017 ICEMR Project; ensure that all study sites in Peru and Brazil have the necessary infrastructure to conduct day-to-day data management activities; assist in the preparation of standardized data collection and protocols, and to provide training on the use of data collection software in tablets in all study sites, guaranteeing data quality, standardization, and comparability across sites; enhance data management and statistics research capacity at the Peruvian and Brazilian partner institutions; provide Project leaders with secure access to a set of validated, easy to use databases with clearly-documented information and ready for analyses; provide systematic guidance on study design and data analysis for the proposed projects and for future modifications to the studies in terms of new projects that emerge from the ICEMR program; and interface with PlasmoDB, GenBank, and VectorBase in order to integrate and make publicly available genetic, genomic, and entomological data from the ICEMR sites. Lastly, as part of our proposed resource sharing plan, data will be deposited in the Harvard Dataverse, a public repository, hosted and maintained by Harvard University Information Technology, and in compliance with Harvard University requirements for good computer use practices, including system security requirements (e.g., idle session timeouts; disabling of generic accounts; inhibiting password guessing); operational requirements (e.g., breach reporting; patching; password complexity; logging); and regular auditing and review.

数据管理和生物统计学核心-核心负责人：Dr. Marcia C.卡斯特罗，HSPH 摘要 数据管理和生物统计核心将提供全面的数据管理和统计 支持亚马逊ICEMR计划的所有项目。它的功能包括：指导研究设计; 研究方案和元数据;确保正确和安全的数据收集、管理和共享;生成 根据项目负责人的要求，定期制作简单的表格;根据需要提供培训;并协助 统计分析核心将在哈佛大学建立，与现有的基础设施相结合 合作伙伴机构，并将与项目负责人和研究人员在研究中无缝集成 网站.核心领导人将是卡斯特罗博士，由兼职数据经理和程序员直接支持， 在哈佛，以及在秘鲁和巴西的全职数据管理员。勒韦林免费提供资源 哈佛的人员，因此在没有成本的ICEMR项目，核心将受益于一个网络， 提供调查规划、生物统计、地理空间建模等高质量服务的顾问， 生物信息学具体来说，核心将创建/组织纵向数据集，并附有字典 2010-2017年ICEMR项目期间在秘鲁和巴西收集的所有调查数据和元数据; 确保秘鲁和巴西的所有研究中心都有必要的基础设施来处理日常数据 管理活动;协助准备标准化的数据收集和协议，并提供 在所有研究中心进行平板电脑数据采集软件使用培训，保证数据质量， 标准化和各地点之间的可比性;加强数据管理和统计研究能力， 秘鲁和巴西的合作机构;为项目负责人提供安全访问一套经过验证， 易于使用的数据库，具有明确记录的信息，并准备进行分析;提供系统的 关于拟议项目的研究设计和数据分析以及今后修改 从ICEMR计划中出现的新项目方面进行研究;并与PlasmoDB接口， GenBank和VectorBase，以便整合并公开提供遗传、基因组和 ICEMR站点的昆虫学数据。最后，作为我们拟议的资源共享计划的一部分， 存放在哈佛Dataverse中，这是一个公共存储库，由哈佛大学托管和维护 信息技术，并符合哈佛大学对计算机使用的要求 实践，包括系统安全要求（例如，空闲会话超时;禁用通用帐户; 禁止密码猜测）;操作要求（例如，违规报告;修补;密码 复杂性;日志记录）;以及定期审计和审查。