Amazonian Center of Excellence in Malaria Research

亚马逊疟疾研究卓越中心

• 批准号: 9911994
• 负责人: MARCIA C. CASTRO
• 金额: $ 10.3万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9911994
• 关键词: Bioinformatics; Biometry; Biostatistics Core; Brazil; Computer Security; Computer software; Computers; Core Facility; Data; Data Analyses; Data Collection; Databases; Deposition; Dictionary; Ensure; Entomology; Future; Genbank; Genetic; Genomics; Human Resources; Information Technology; Infrastructure; Institutes; Institution; Malaria; Metadata; Modeling; Modification; Participant; Peru; Peruvian; Preparation; Protocols documentation; Reporting; Research; Research Design; Research Personnel; Resource Sharing; Resources; Role; Secure; Services; Site; Standardization; Statistical Data Interpretation; Structure; Surveys; Tablets; Techniques; Time; Training; Universities; Work; base; cost; data management; data quality; data standards; longitudinal dataset; programs; public repository; skills; statistics

Data Management and Biostatistics Core - Core Leader: Dr. Marcia C. Castro, HSPH ABSTRACT The Data Management and Biostatistics Core will provide comprehensive data management and statistical support for all Projects of the Amazonia ICEMR Program. Its functions include: guide study design; develop study protocols and metadata; ensure proper and safe data collection, management, and sharing; generate simple tabulations routinely and as requested by Project leaders; provide training as needed; and assist with statistical analysis. The Core will be instituted at Harvard University, integrated with the existing infrastructure of the partner institutions, and will work in seamless integration with Project leaders and researchers in study sites. The Core Leader will be Dr. Castro, directly supported by a part-time data manager & programmer based at Harvard, and by full-time data managers available in Peru and Brazil. Levering resources freely available to Harvard personnel, and thus at no cost to the ICEMR project, the Core will benefit from a network of consultants that offer high quality services on survey planning, biostatistics, geospatial modeling, and bioinformatics. Specifically, the Core will create/organize longitudinal datasets, accompanied by dictionaries and metadata, of all survey data previously collected in Peru and Brazil during the 2010-2017 ICEMR Project; ensure that all study sites in Peru and Brazil have the necessary infrastructure to conduct day-to-day data management activities; assist in the preparation of standardized data collection and protocols, and to provide training on the use of data collection software in tablets in all study sites, guaranteeing data quality, standardization, and comparability across sites; enhance data management and statistics research capacity at the Peruvian and Brazilian partner institutions; provide Project leaders with secure access to a set of validated, easy to use databases with clearly-documented information and ready for analyses; provide systematic guidance on study design and data analysis for the proposed projects and for future modifications to the studies in terms of new projects that emerge from the ICEMR program; and interface with PlasmoDB, GenBank, and VectorBase in order to integrate and make publicly available genetic, genomic, and entomological data from the ICEMR sites. Lastly, as part of our proposed resource sharing plan, data will be deposited in the Harvard Dataverse, a public repository, hosted and maintained by Harvard University Information Technology, and in compliance with Harvard University requirements for good computer use practices, including system security requirements (e.g., idle session timeouts; disabling of generic accounts; inhibiting password guessing); operational requirements (e.g., breach reporting; patching; password complexity; logging); and regular auditing and review.

数据管理和生物统计核心 - 核心领导者：Marcia C. Castro 博士，HSPH 抽象的 数据管理和生物统计核心将提供全面的数据管理和统计 支持 Amazonia ICEMR 计划的所有项目。其功能包括：指导研究设计；发展 研究方案和元数据；确保正确、安全的数据收集、管理和共享；产生 按照项目负责人的要求定期进行简单的表格；根据需要提供培训；并协助 统计分析。核心将在哈佛大学建立，与现有基础设施整合 合作机构的成员，并将与项目负责人和研究人员无缝对接 网站。核心领导者将是卡斯特罗博士，由兼职数据经理和程序员直接支持 哈佛大学以及秘鲁和巴西的全职数据经理。利用免费可用的资源 哈佛人员，因此在 ICEMR 项目不花费任何费用的情况下，核心将受益于一个网络 提供调查规划、生物统计、地理空间建​​模等方面高质量服务的顾问 生物信息学。具体来说，核心将创建/组织纵向数据集，并附有字典 先前在 2010-2017 年 ICEMR 项目期间在秘鲁和巴西收集的所有调查数据的元数据； 确保秘鲁和巴西的所有研究地点都拥有必要的基础设施来进行日常数据处理 管理活动；协助准备标准化数据收集和协议，并提供 在所有研究地点进行平板电脑数据收集软件使用培训，保证数据质量， 标准化和跨站点的可比性；加强数据管理和统计研究能力 秘鲁和巴西合作机构；为项目领导者提供对一组经过验证的、 易于使用的数据库，具有清晰记录的信息并可供分析；提供系统化的 关于拟议项目的研究设计和数据分析以及未来修改的指导 研究 ICEMR 计划中出现的新项目；并与 PlasmoDB 接口， GenBank 和 VectorBase，以便整合并公开遗传、基因组和 来自 ICEMR 站点的昆虫学数据。最后，作为我们提议的资源共享计划的一部分，数据将被 存放在由哈佛大学托管和维护的公共存储库哈佛数据宇宙中 信息技术，并符合哈佛大学良好使用计算机的要求 实践，包括系统安全要求（例如空闲会话超时；禁用通用帐户； 禁止密码猜测）；操作要求（例如，违规报告；修补；密码 复杂;记录）；以及定期审核和审查。