SES health gradients in late life: testing models of gene-environment interplay in an international twin consortium

晚年的 SES 健康梯度：在国际双胞胎联盟中测试基因与环境相互作用的模型

• 批准号: 10440382
• 负责人: Brian K. Finch
• 金额: $ 54.96万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10440382
• 关键词: Accounting; Activities of Daily Living; Address; Adult; Affect; Age; Aging; Area; Australia; Blood Pressure; Body mass index; Capital; Characteristics; Chronic Disease; Classification; Cognitive; Cohort Studies; Collaborations; Coronary Arteriosclerosis; Country; Data; Data Collection; Data Set; Denmark; Disease; Disease susceptibility; Dizygotic Twins; Economic Conditions; Education; Elderly; Emotional; Environment; Environmental Risk Factor; Exposure to; Financial Hardship; Finland; Genes; Genetic; Genetic Predisposition to Disease; Genotype; Goals; Hand Strength; Health; Health Policy; Health Promotion; Health Status; Healthy People 2020; Human; Income; Individual; Inherited; Intake; International; Life Cycle Stages; Life Style; Loneliness; Measures; Mediating; Mental Depression; Methods; Modeling; Monozygotic twins; Nature; Occupational; Occupations; Outcome; Participant; Phenotype; Physical Exercise; Poverty; Prevention strategy; Quantitative Genetics; Research; Research Personnel; Resources; Risk; Role; Sampling; Sex Differences; Social Class; Social Policies; Social status; Social stratification; Societies; Socioeconomic Status; Stress; Structure; Sweden; Testing; Time; Toxic effect; Translating; Twin Multiple Birth; Twin Studies; Vision; Woman; Women' s Health; Work; cohort; cost effective; design; disorder risk; environmental enrichment for laboratory animals; genome-wide; health economics; health inequalities; indexing; innovation; low socioeconomic status; memory process; men; physical conditioning; polygenic risk score; population health; processing speed; public health priorities; pulmonary function; safety net; sex; social; social health determinants; social inequality; socioeconomics; tool

Inequalities in health outcomes are targeted by Healthy People 2020 as a public health priority. The social stratification of health is well documented, pervasive, and of growing concern because it appears to be increasing over time. Reducing these social class disparities will require greater understanding of how social class impacts health than we currently have. While most research focuses on individual-level socioeconomic status—defined as social status that accrues to occupational classification, education, and income—new research has begun to focus on the macro-economic environment. Further, although both genetic (G) and environmental (E) factors are known to contribute to the SES-health gradient, the mechanisms by which the two sets of factors combine to influence health outcomes (i.e., GE interplay) are poorly understood. Models of GE interplay differ in their environmental focus (disease-triggering effects of toxic environments vs. health- promoting benefits of favorable environments) and the expected genetic contribution to disease (maximized in adverse environments, in favorable environments, or at both extremes) Understanding whether high-SES preferentially promotes good health among a genetically selected subset of individuals (i.e., social enhancement), whether low-SES triggers poor health among a genetically vulnerable subset of individuals (i.e., diathesis-stress), or both, is essential for translating research in this area into effective prevention strategies. The consortium on Interplay of Genes and Environments across Multiple Studies (IGEMS) with 16 existing longitudinal twin studies in the U.S., Sweden, Denmark, Finland, and Australia is poised to evaluate these models. IGEMS includes more than 52,000 individual twins, with over 7000 identical twin pairs for within-pair difference models, and over 12,600 dizygotic twin pairs with nearly 4000 opposite sex pairs for sex-difference models. The sample spans a wide age range (15 to 103 years at intake) and includes a set of well-characterized longitudinal phenotypes, including harmonized measures of physical health (e.g., subjective health, chronic disease indicators, body mass index, lung function, blood pressure, activities of daily living, and grip strength), cognitive health (verbal ability, spatial ability, memory, and processing speed), and emotional health (depression, loneliness) as well as measures of multiple facets of SES (e.g., occupation, education, financial strain). In addition, a large subset of IGEMS participants has genome wide genotyping from which we have computed polygenic risk scores (PRS). We will use co-twin control/within pair models, quantitative genetic moderation, sex-limitation models, and PRS analyses to investigate specific mechanisms of the SES-health gradient at the individual level as well as the country and historical cohort level (e.g., country-level indices of social inequality). The proposed study reflects an innovative vision by the investigators who—rather than addressing the research questions through new data collection—successfully created a collaboration among 16 large international studies with relevant phenotypes, making this study highly cost-effective and efficient.

《2020年健康人》将健康结果不平等作为一项公共卫生优先事项。的社会

项目成果

Erectile Function, Sexual Satisfaction, and Cognitive Decline in Men From Midlife to Older Adulthood.

中年到老年男性的勃起功能、性满意度和认知能力下降。

• DOI: 10.1093/geront/gnac151
• 发表时间: 2023
• 期刊: The Gerontologist
• 作者: Slayday,RikiE;Bell,TylerR;Lyons,MichaelJ;WarrenBa,TeresaS;Toomey,Rosemary;Vandiver,Richard;Sliwinski,MartinJ;Kremen,WilliamS;Franz,CarolE
• 通讯作者: Franz,CarolE

Periventricular and deep abnormal white matter differ in associations with cognitive performance at midlife.

• DOI: 10.1037/neu0000718
• 发表时间: 2021-03
• 期刊: Neuropsychology
• 影响因子: 2.4
• 作者: Sanderson-Cimino M;Panizzon MS;Elman JA;Tu X;Gustavson DE;Puckett O;Cross K;Notestine R;Hatton SN;Eyler LT;McEvoy LK;Hagler DJ;Neale MC;Gillespie NA;Lyons MJ;Franz CE;Fennema-Notestine C;Kremen WS
• 通讯作者: Kremen WS

Interaction between Alcohol Consumption and Apolipoprotein E (ApoE) Genotype with Cognition in Middle-Aged Men.

饮酒与载脂蛋白E（APOE）基因型与中年男性认知之间的相互作用。

• DOI: 10.1017/s1355617720000570
• 发表时间: 2021-01
• 期刊: Journal of the International Neuropsychological Society : JINS
• 作者: Slayday RE;Gustavson DE;Elman JA;Beck A;McEvoy LK;Tu XM;Fang B;Hauger RL;Lyons MJ;McKenzie RE;Sanderson-Cimino ME;Xian H;Kremen WS;Franz CE
• 通讯作者: Franz CE

Predicting Health-Related Quality of Life in Trauma-Exposed Male Veterans in Late Midlife: A 20 Year Longitudinal Study.

预测中年晚期遭受创伤的男性退伍军人与健康相关的生活质量：一项 20 年纵向研究。

• DOI: 10.3390/ijerph17124554
• 发表时间: 2020
• 期刊: International journal of environmental research and public health
• 作者: Stevens,SamanthaM;Gustavson,DanielE;Fang,Bin;Tu,Xin;Logue,Mark;Lyons,MichaelJ;Reynolds,ChandraA;Kremen,WilliamS;Franz,CarolE
• 通讯作者: Franz,CarolE

Interplay of body mass index and metabolic syndrome: association with physiological age from midlife to late-life.

• DOI: 10.1007/s11357-023-01032-9
• 发表时间: 2024-04
• 期刊: GEROSCIENCE
• 影响因子: 5.6
• 作者: Ler, Peggy;Ploner, Alexander;Finkel, Deborah;Reynolds, Chandra A.;Zhan, Yiqiang;Jylhava, Juulia;Aslan, Anna K. Dahl;Karlsson, Ida K.
• 通讯作者: Karlsson, Ida K.