MID-CAREER AWARD IN PATIENT-ORIENTED DRUG ABUSE RESEARCH

项目摘要 药物滥用和成瘾是一种毁灭性的慢性疾病，在医疗、金融、法律的 给我们国家带来了沉重的社会负担。跨学科合作与技术进步相结合， 在前所未有的机会，以提高成瘾治疗的疗效和持久性，并减少脆弱性， 上瘾。持续进展对于改善现有的循证治疗和开发新的治疗方法至关重要 治疗。因此，吸引和培训临床研究人员至关重要，以确保多样化的人才库 高技能的科学家将能够满足这些紧迫的医疗保健需求。艾米·麦克雷-克拉克博士是一位 一位富有成效的职业中期调查员，她一直为她在美国国家卫生研究院的创新工作提供资金。 药物开发领域和成瘾方面的性别差异。此外，她有一个强大的跟踪记录， 吸引并成功指导医学生、研究生和博士后学生以及初级教师 在专注于物质使用障碍的临床研究中，她以前的成就证明了这一点。 K24奖这项以患者为导向的研究更新申请的中期职业研究者奖的目的 是为受保护的时间提供支持，以便麦克雷-克拉克博士能够扩大她的正式，密集的计划， 指导临床研究培训和职业发展活动，以促进在该领域的初级学者 药物滥用和成瘾。与她最初获奖时一样，还将特别强调增加 代表性不足的少数民族、妇女和其他不同的个人参与以病人为导向的 research.此外，她还将在现有研究计划的基础上， 研究方向，包括在导师和领导力方面获得进一步的教学和经验培训 技能发展;参与阿片类药物治疗相关的倡议和研究;并将其工作扩展到 完善临床试验远程监控技术。

PROJECT SUMMARY Drug abuse and addiction are devastating and chronic conditions that place a significant medical, financial, legal and social burden on our country. Interdisciplinary collaboration combined with technical advances has resulted in unprecedented opportunities to enhance addiction treatment efficacy and durability, and reduce vulnerability to addiction. Continued progress is vital to improving existing evidenced-based treatments and developing new treatments. It is therefore critical to attract and train clinical researchers in order to ensure that a diverse pool of highly skilled scientists will be available to address these urgent health care needs. Dr. Aimee McRae-Clark is a productive mid-career investigator who has maintained consistent NIH funding for her innovative work in the area of medications development and gender differences in addictions. In addition, she has a strong track-record of attracting and successfully mentoring medical, graduate and post-doctoral students as well as junior faculty in clinical research focused on substance use disorders, as evidenced by the accomplishments of her previous K24 award. The objective of this Midcareer Investigator Award in Patient-Oriented Research renewal application is to provide support for protected time so that Dr. McRae-Clark can expand her formal, intensive program of mentored clinical research training and career development activities to promote junior scholars in the area of drug abuse and addiction. As in her initial award, particular emphasis will also be placed on increasing the participation of underrepresented minorities, women, and other diverse individuals conducting patient-oriented research. In addition, she will build on her existing program of research by incorporating new proficiencies and research directions, including obtaining further didactic and experiential training in mentorship and leadership skill development; participating in opioid treatment-related initiatives and research; and expanding her work to improve clinical trial remote monitoring technology.