MID-CAREER AWARD IN PATIENT-ORIENTED DRUG ABUSE RESEARCH

项目总结 药物滥用和上瘾是毁灭性的慢性疾病，给医疗、经济、法律等方面带来了巨大的 以及我们国家的社会负担。跨学科协作与技术进步相结合，产生了 在前所未有的机会中提高成瘾治疗的有效性和持久性，并减少脆弱性 为了上瘾。持续的进展对于改进现有的循证治疗和开发新的治疗方法至关重要 治疗。因此，吸引和培训临床研究人员是至关重要的，以确保建立一个多样化的 高技能的科学家将可用于解决这些紧迫的卫生保健需求。艾米·麦克雷-克拉克博士是一位 职业生涯中期富有成效的研究员，她一直为NIH的创新工作提供持续的资金 药物开发领域和成瘾方面的性别差异。此外，她的记录也很好 吸引和成功地指导医学、研究生和博士后以及初级教师 专注于药物使用障碍的临床研究，她以前的成就证明了这一点 K24奖。这一职业生涯中期研究人员奖的目标是以患者为中心的研究更新应用 是为受保护的时间提供支持，这样麦克雷-克拉克博士就可以扩大她的正式、密集的计划 指导临床研究培训和职业发展活动，促进初级学者在以下领域的研究 滥用药物和上瘾。与她最初获奖时一样，她还将特别强调增加 代表不足的少数群体、妇女和其他以病人为导向的不同个人的参与 研究。此外，她将在现有研究计划的基础上，纳入新的熟练程度和 研究方向，包括获得进一步的指导性和经验性指导和领导能力培训 技能发展；参与与阿片类药物治疗相关的倡议和研究；并将她的工作扩大到 完善临床试验远程监测技术。

PROJECT SUMMARY Drug abuse and addiction are devastating and chronic conditions that place a significant medical, financial, legal and social burden on our country. Interdisciplinary collaboration combined with technical advances has resulted in unprecedented opportunities to enhance addiction treatment efficacy and durability, and reduce vulnerability to addiction. Continued progress is vital to improving existing evidenced-based treatments and developing new treatments. It is therefore critical to attract and train clinical researchers in order to ensure that a diverse pool of highly skilled scientists will be available to address these urgent health care needs. Dr. Aimee McRae-Clark is a productive mid-career investigator who has maintained consistent NIH funding for her innovative work in the area of medications development and gender differences in addictions. In addition, she has a strong track-record of attracting and successfully mentoring medical, graduate and post-doctoral students as well as junior faculty in clinical research focused on substance use disorders, as evidenced by the accomplishments of her previous K24 award. The objective of this Midcareer Investigator Award in Patient-Oriented Research renewal application is to provide support for protected time so that Dr. McRae-Clark can expand her formal, intensive program of mentored clinical research training and career development activities to promote junior scholars in the area of drug abuse and addiction. As in her initial award, particular emphasis will also be placed on increasing the participation of underrepresented minorities, women, and other diverse individuals conducting patient-oriented research. In addition, she will build on her existing program of research by incorporating new proficiencies and research directions, including obtaining further didactic and experiential training in mentorship and leadership skill development; participating in opioid treatment-related initiatives and research; and expanding her work to improve clinical trial remote monitoring technology.