An Integrative Longitudinal Analysis of Neural Rhythms in Early Development

早期发育神经节律的综合纵向分析

• 批准号: 10446689
• 负责人: Martha Ann Bell
• 金额: $ 64.46万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10446689
• 关键词: Address; Adult; Affective; Age; Age-Months; Alpha Rhythm; Behavioral; Brain; Characteristics; Child; Cognitive; Communication; Complex; Coupling; Development; Electroencephalography; Frequencies; Future; Goals; Individual; Individual Differences; Infant; Informal Social Control; Investigation; Knowledge; Link; Literature; Measures; Methodology; Methods; Motor; Outcome; Participant; Pattern; Practice Guidelines; Procedures; Process; Property; Research; Rest; Risk; Scientist; Signal Transduction; Standardization; System; Techniques; Time; brain electrical activity; cognitive neuroscience; community based participatory research; early childhood; infancy; interest; longitudinal analysis; myelination; psychologic; public health relevance; relating to nervous system; spatiotemporal; synaptic pruning; transmission process

PROJECT SUMMARY / ABSTRACT Our investigation is a developmental cognitive neuroscience examination of neural processing during early development. Brain electrical activity consists of multiple, co-occurring oscillatory rhythms that underlie functions critical to simple and complex brain processes. Spatiotemporal characteristics, functional properties, neural generators, and psychological correlates characterize these individual oscillatory rhythms in adult research. These neural signatures are essential for our understanding of brain processes involved in early self-regulatory cognitive and affective processes. Methods for examining brain systems and their oscillatory signals in infants and children, however, have long been non-systematic, lacking the level of standardization, sophistication, and scientific rigor seen in the adult research literature. There is a need for research that characterizes early brain functioning in typically developing infants and young children because it allows scientists to distinguish individual differences in development from at-risk trajectories. Our goal is to provide the first comprehensive and systematic analysis of longitudinal changes in EEG rhythms across infancy and early childhood. Our systematic examination of multiple oscillatory rhythms (delta, theta, alpha/mu, beta) will enhance understanding of their frequency signatures, spatial topographies, and functional properties, all within a developmental time course. We will address three research aims. 1) We will identify and compare developmentally appropriate techniques of characterizing neural oscillatory rhythms. 2) We will characterize ontogenetic changes in neural oscillatory rhythms and their interactions. 3) We will determine whether individual differences in neural oscillation parameters and their developmental trajectories are related to developmental outcomes.

项目总结/摘要 我们的研究是一个发展认知神经科学检查的神经加工过程中， 发展脑电活动由多个共同发生的振荡节律组成，这些节律是功能的基础 对简单和复杂的大脑过程至关重要。时空特征，功能特性，神经 发电机和心理相关的特点，这些个人的振荡节奏在成人研究。 这些神经信号对于我们理解参与早期自我调节的大脑过程至关重要。 认知和情感过程。婴儿脑系统及其振荡信号的检查方法 然而，儿童长期以来一直是非系统性的，缺乏标准化，复杂化， 在成人研究文献中看到的科学严谨性。有必要进行研究， 在发育中的婴儿和幼儿中发挥作用，因为它使科学家能够区分个体 发展与风险轨迹的差异。我们的目标是提供第一个全面和 婴儿期和幼儿期脑电图节律纵向变化的系统分析。我们的系统 检查多种振荡节律（δ，θ，α/μ，β）将增强对它们的理解。 频率特征、空间地形和功能特性，所有这些都在发育时间过程中。 我们将讨论三个研究目标。1)我们将确定和比较适合发展的技术 神经振荡节律的特征。2)我们将描述神经振荡的个体发育变化， 节奏及其相互作用。3)我们将确定神经振荡的个体差异 参数及其发展轨迹与发展结果有关。