Clinical Qualification of Imaging and Fluid-Based Tumor Monitoring Biomarkers for Metastatic Castration Resistant Prostate Cancer
转移性去势抵抗性前列腺癌的影像学和基于液体的肿瘤监测生物标志物的临床资格
基本信息
- 批准号:10447573
- 负责人:
- 金额:$ 68.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2023-06-30
- 项目状态:已结题
- 来源:
- 关键词:AftercareAmericanBiological AssayBiological MarkersBone TissueCancer EtiologyCaringCessation of lifeCholineClinicalClinical TrialsDataData SetDevelopmentDiseaseEventFOLH1 geneFutureGoalsGuidelinesImageImaging TechniquesLesionLiquid substanceLymphMalignant neoplasm of prostateMeasurementMeasuresMetastatic Neoplasm to the BoneMetastatic Prostate CancerMethodsModalityModelingMolecularMonitorNeoplasm Circulating CellsOutcomePatientsPerformancePhase III Clinical TrialsPositron-Emission TomographyPrednisonePrognosisPrognostic FactorProgression-Free SurvivalsRadiation therapyRadionuclide ImagingRadiumRecommendationResearchResearch DesignSoft Tissue DisorderStandardizationStatistical ModelsTechniquesTestingTimeTrainingTumor BurdenValidationabirateronebasebonebone imagingburden of illnesscastration resistant prostate cancerchemotherapyclinical caredocetaxeldrug developmentimage processingimaging biomarkerimaging modalityimprovedindexingkinetic modelliquid biopsylymph nodesmennovelnovel imaging techniquenovel therapeuticspredicting responsepredictive modelingprognostic modelprogression markerprospectiveradiological imagingresponseserial imagingsoft tissuetemporal measurementtime usetreatment effecttreatment responsetumorworking group
项目摘要
Metastatic prostate cancer is the second largest cause of cancer-related death in American men. A major
obstacle to their treatment and to developing new drugs for this disease is the lack of reliable quantitative
treatment monitoring methods. Fluid-based tumor monitoring using circulating tumor cells (CTC) has
recently proven valuable for prognosis and predicting response to treatment. Current imaging methods for
treatment monitoring in prostate cancer involve lesion-counting of new bone metastases or selected index
lesions of soft tissue disease; both focus on progression only and cannot assess the full disease burden.
This proposal deploys two validated methods, automated bone scan index (aBSI) and lymph node
segmentation, to quantify standard imaging results so that a measure of total disease burden on imaging
can be integrated with CTC data in a predictive model. The hypothesis that this model will outperform
current methods for monitoring response to therapy will be tested via these specific aims: 1) Correlate
quantitative post-treatment changes in tumor burden as assessed by imaging and CTC’s; 2) Determine
whether a combination of fluid-based tumor monitoring (liquid biopsy) and an imaging assay is more
powerful than either assay alone in prognosticating for survival; 3) Identify the optimal combination of liquid
biopsy and imaging for different therapies. Models will be built to predict overall survival using imaging,
CTC, and prognostic factor data from phase III clinical trials of first-line treatments, docetaxel, docetaxel +
radium-223, and abiraterone + prednisone, for an advanced stage of disease, metastatic castration-
resistant prostate cancer (mCRPC). Clinical trials including this data are available for analysis due to the
recommendations for serial imaging (CT and bone scintigraphy) and CTC assessment as endpoints in the
Prostate Cancer Working Group (PCWG) 3 guidelines, co-authored by the study team. The results of this
study will create the first reliable, multiparametric, and fully quantitative biomarker that captures clinically
meaningful indices of both response and progression in mCRPC; generate evidence to support its inclusion
in future PCWG guidelines; and develop methods applicable to new imaging modalities.
转移性前列腺癌是美国男性癌症相关死亡的第二大原因。一个主要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
MICHAEL J MORRIS其他文献
EFFECTS OF PARTICULATE MATTER INHALATION ON CHEST IMAGING DURING DEPLOYMENT TO OPERATION INHERENT RESOLVE (OIR)
- DOI:
10.1016/j.chest.2022.08.1649 - 发表时间:
2022-10-01 - 期刊:
- 影响因子:
- 作者:
TYSON J SJULIN;MICHAEL J MORRIS;SALLY DELVECCHIO;GIOVANNI LORENZ;BENJAMIN P ILIFF - 通讯作者:
BENJAMIN P ILIFF
CASE REPORT: USE OF THE SERAPH-100 BLOOD FILTER IN LINE WITH EXTRACORPOREAL MEMBRANE OXYGENATION CIRCUIT FOR TREATMENT OF SEPTIC SHOCK FROM ENTEROCOCCUS FAECALIS BACTEREMIA
病例报告:在体外膜氧合回路中使用 SERAPH-100 血液过滤器联合治疗粪肠球菌菌血症所致的感染性休克
- DOI:
10.1016/j.chest.2022.08.800 - 发表时间:
2022-10-01 - 期刊:
- 影响因子:8.600
- 作者:
STEVEN STOFFEL;JOSHUA BOSTER;HENRY DANCHI;MELISSA ROSAS;MICHAEL J MORRIS;MAI T NGUYEN;ROBERT J WALTER - 通讯作者:
ROBERT J WALTER
CHARACTERIZING THE ASTHMA PHENOTYPE OF SERVICE-CONNECTED MEDICALLY SEPARATED MILITARY PERSONNEL
- DOI:
10.1016/j.chest.2023.07.3171 - 发表时间:
2023-10-01 - 期刊:
- 影响因子:
- 作者:
JOSHUA BOSTER;STEVEN STOFFEL;WILLIAM MOORE;MICHAEL J MORRIS - 通讯作者:
MICHAEL J MORRIS
REPEAT PULMONARY FUNCTION TESTING IN ACTIVE DUTY MILITARY FOR PULMONARY DISEASES RELATED TO ENVIRONMENTAL DEPLOYMENT EXPOSURES (STAMPEDE III)
- DOI:
10.1016/j.chest.2022.08.1651 - 发表时间:
2022-10-01 - 期刊:
- 影响因子:
- 作者:
STEVEN STOFFEL;JESS T. ANDERSON;MATEO HOULE;ROBERT J WALTER;MICHAEL J MORRIS - 通讯作者:
MICHAEL J MORRIS
ETIOLOGIES AND CHARACTERISTICS OF INTERSTITIAL LUNG DISEASE IN AN ACTIVE-DUTY MILITARY POPULATION
- DOI:
10.1016/j.chest.2023.07.2064 - 发表时间:
2023-10-01 - 期刊:
- 影响因子:
- 作者:
WILLIAM MOORE;JOSHUA BOSTER;MICHAEL J MORRIS;IAN CHR MCINNIS;BRIAN S BARBER;MICHAEL A GONZALES - 通讯作者:
MICHAEL A GONZALES
MICHAEL J MORRIS的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('MICHAEL J MORRIS', 18)}}的其他基金
MATCHES: Making Telehealth Delivery of Cancer Care at Home Effective and Safe
匹配:使远程医疗在家中提供有效且安全的癌症护理
- 批准号:
10673980 - 财政年份:2022
- 资助金额:
$ 68.99万 - 项目类别:
MATCHES: Making Telehealth Delivery of Cancer Care at Home Effective and Safe - Addressing missing data in the MATCHES study to improve ML/AI readiness
MATCHES:使远程医疗在家中有效且安全地提供癌症护理 - 解决 MATCHES 研究中缺失的数据,以提高 ML/AI 的准备情况
- 批准号:
10842906 - 财政年份:2022
- 资助金额:
$ 68.99万 - 项目类别:
MATCHES: Making Telehealth Delivery of Cancer Care at Home Effective and Safe
匹配:使远程医疗在家中提供有效且安全的癌症护理
- 批准号:
10454670 - 财政年份:2022
- 资助金额:
$ 68.99万 - 项目类别:
Clinical Qualification of Imaging and Fluid-Based Tumor Monitoring Biomarkers for Metastatic Castration Resistant Prostate Cancer
转移性去势抵抗性前列腺癌的影像学和基于液体的肿瘤监测生物标志物的临床资格
- 批准号:
9974088 - 财政年份:2020
- 资助金额:
$ 68.99万 - 项目类别:
Clinical Qualification of Imaging and Fluid-Based Tumor Monitoring Biomarkers for Metastatic Castration Resistant Prostate Cancer
转移性去势抵抗性前列腺癌的影像学和基于液体的肿瘤监测生物标志物的临床资格
- 批准号:
10868060 - 财政年份:2020
- 资助金额:
$ 68.99万 - 项目类别:
相似海外基金
Collaborative Research: REU Site: Earth and Planetary Science and Astrophysics REU at the American Museum of Natural History in Collaboration with the City University of New York
合作研究:REU 地点:地球与行星科学和天体物理学 REU 与纽约市立大学合作,位于美国自然历史博物馆
- 批准号:
2348998 - 财政年份:2025
- 资助金额:
$ 68.99万 - 项目类别:
Standard Grant
Collaborative Research: REU Site: Earth and Planetary Science and Astrophysics REU at the American Museum of Natural History in Collaboration with the City University of New York
合作研究:REU 地点:地球与行星科学和天体物理学 REU 与纽约市立大学合作,位于美国自然历史博物馆
- 批准号:
2348999 - 财政年份:2025
- 资助金额:
$ 68.99万 - 项目类别:
Standard Grant
Collaborative Research: Ionospheric Density Response to American Solar Eclipses Using Coordinated Radio Observations with Modeling Support
合作研究:利用协调射电观测和建模支持对美国日食的电离层密度响应
- 批准号:
2412294 - 财政年份:2024
- 资助金额:
$ 68.99万 - 项目类别:
Standard Grant
Conference: Doctoral Consortium at Student Research Workshop at the Annual Conference of the North American Chapter of the Association for Computational Linguistics (NAACL)
会议:计算语言学协会 (NAACL) 北美分会年会学生研究研讨会上的博士联盟
- 批准号:
2415059 - 财政年份:2024
- 资助金额:
$ 68.99万 - 项目类别:
Standard Grant
Conference: Polymeric Materials: Science and Engineering Division Centennial Celebration at the Spring 2024 American Chemical Society Meeting
会议:高分子材料:美国化学会 2024 年春季会议科学与工程部百年庆典
- 批准号:
2415569 - 财政年份:2024
- 资助金额:
$ 68.99万 - 项目类别:
Standard Grant
Collaborative Research: RUI: Continental-Scale Study of Jura-Cretaceous Basins and Melanges along the Backbone of the North American Cordillera-A Test of Mesozoic Subduction Models
合作研究:RUI:北美科迪勒拉山脊沿线汝拉-白垩纪盆地和混杂岩的大陆尺度研究——中生代俯冲模型的检验
- 批准号:
2346565 - 财政年份:2024
- 资助金额:
$ 68.99万 - 项目类别:
Standard Grant
REU Site: Research Experiences for American Leadership of Industry with Zero Emissions by 2050 (REALIZE-2050)
REU 网站:2050 年美国零排放工业领先地位的研究经验 (REALIZE-2050)
- 批准号:
2349580 - 财政年份:2024
- 资助金额:
$ 68.99万 - 项目类别:
Standard Grant
Collaborative Research: RUI: Continental-Scale Study of Jura-Cretaceous Basins and Melanges along the Backbone of the North American Cordillera-A Test of Mesozoic Subduction Models
合作研究:RUI:北美科迪勒拉山脊沿线汝拉-白垩纪盆地和混杂岩的大陆尺度研究——中生代俯冲模型的检验
- 批准号:
2346564 - 财政年份:2024
- 资助金额:
$ 68.99万 - 项目类别:
Standard Grant
Conference: Latin American School of Algebraic Geometry
会议:拉丁美洲代数几何学院
- 批准号:
2401164 - 财政年份:2024
- 资助金额:
$ 68.99万 - 项目类别:
Standard Grant
Conference: North American High Order Methods Con (NAHOMCon)
会议:北美高阶方法大会 (NAHOMCon)
- 批准号:
2333724 - 财政年份:2024
- 资助金额:
$ 68.99万 - 项目类别:
Standard Grant