MATCHES: Making Telehealth Delivery of Cancer Care at Home Effective and Safe

项目概要/摘要 比赛（使远程医疗在家中提供有效且安全的癌症护理）远程医疗研究 该中心旨在建立必要的证据基础，以建立远程医疗癌症的最佳实践 关心。该中心的总体目标是创建一个研究中心，生成证据、培训 研究人员，并开发点燃精准癌症护理领域所需的研究方法。 先前的工作表明，以肿瘤学为重点的远程医疗可以取得良好的结果，但大规模 试验仅限于姑息治疗或幸存者等特定情况。采用受到限制 通过限制性偿还。比赛中心将通过执行来帮助弥补这一证据差距 前瞻性试验、进行观察分析以及培训跨学科研究人员。我们的研究 主题侧重于来自远程医疗平台、患者门户、移动设备的多层数据的集成 跟踪设备和电子病历，以开发支持个性化的分析方法 关心。我们的目标是开发肿瘤学的新范式——精准交付——最终目标是匹配 个体患者拥有基于诊所或远程医疗支持的家庭环境的最有益组合 在适当的时间进行护理——所有这些都基于动态可用数据的整体。我们将完成这个 通过应用数据科学方法（包括灵活的试验设计和机器学习）来实现目标 迄今为止，远程医疗的应用有限。通过建立一个研究中心来培养跨领域的研究人员 学科并提供培训、工具、数据、分析方法以及共享知识和构建的场所 通过伙伴关系，我们期望加快医疗服务科学的进展。我们的具体目标是 1) 对肿瘤学远程医疗进行有效的务实试验，2) 分析大量现有的信息 表征远程医疗利用和结果的多维观察数据，3) 培训调查人员 并为他们配备在循证框架内进行创新所需的技能，以及 4) 整合 远程医疗与其他数据流并创建和应用分析方法来改变精确领域 护理服务。行政核心将协调活动并吸收内部和外部的反馈 利益相关者——包括患者和肿瘤学工作人员。我们的临床实践网络作为 创新实验室，由纽约州和新泽西州的 7 个门诊诊所组成，具有共享的信息学生态系统 包括远程医疗能力、数字监控和高流量的患者门户。这将使我们能够 启动并执行一项大型务实试验，比较现场护理与远程医疗，并利用旨在 使用整群随机设计支持家庭护理。研究与方法核心将支持 中心应用数据科学方法从远程医疗和其他数据中提取和综合见解 致力于开发与推进精准癌症护理服务和公平目标相关的方法， 功效和效率，为癌症治疗患者创造最佳体验。

Project Summary/Abstract The MATCHES (Making Telehealth Delivery of Cancer Care at Home Effective and Safe) Telehealth Research Center aims to build the evidence base necessary to establish best practices for telehealth-enabled cancer care. The overarching goal of the Center is to create a research hub that generates evidence, trains investigators, and develops the research methods required to ignite the field of precision cancer care delivery. Prior work demonstrates that oncology-focused telehealth can achieve favorable outcomes, but large-scale trials have been limited to specific contexts like palliative care or survivorship. Adoption has been constrained by restricted reimbursement. The MATCHES Center will help remediate this evidence gap by executing prospective trials, conducting observational analyses, and training transdisciplinary researchers. Our research theme focuses on the integration of multi-layered data from telehealth platforms, patient portals, mobile tracking devices, and the electronic medical record to develop analytic methods that support personalized care. We aim to develop a new paradigm in oncology—precision delivery—with the ultimate goal of matching individual patients with the most beneficial combination of clinic-based or telehealth-supported home-setting care at the appropriate time—all based on the totality of dynamically available data. We will accomplish this goal by applying data science methods—including nimble trial designs and machine learning—that have had limited application to telehealth to date. By establishing a research hub that nurtures investigators across disciplines and provides training, tools, data, analytic methods, and venues for sharing knowledge and building partnerships, we expect to accelerate progress in the science of care delivery. Our specific aims are 1) to conduct impactful pragmatic trials of telehealth in oncology, 2) to analyze a large existing cache of multidimensional observational data characterizing telehealth utilization and outcomes, 3) to train investigators and equip them with the skills necessary to innovate within an evidence-based framework, and 4) to integrate telehealth with other data streams and create and apply analytic methods to transform the field of precision care delivery. An Administrative Core will coordinate activities and engage feedback from internal and external stakeholders—including patients and the oncology workforce. Our Clinical Practice Network serves as an innovation laboratory and comprises 7 outpatient clinics in NY and NJ with a shared informatics ecosystem including telehealth capacity, digital monitoring, and a highly trafficked patient portal. This will enable us to launch and execute a large pragmatic trial comparing in-person care to telehealth, with resources designed to support home-based care using a cluster-randomized design. The Research & Methods Core will support the Center by applying data science methods to extract and synthesize insights from telehealth and other data streams to develop methods relevant to advancing precision cancer care delivery and the goals of equity, efficacy, and efficiency to create an optimal experience for people being treated for cancer.