Core C: Microbial Engineering and Transplantation Core
核心 C:微生物工程和移植核心
基本信息
- 批准号:10447067
- 负责人:
- 金额:$ 21.74万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-01 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:Anaerobic BacteriaAnimalsAtherosclerosisBacteroidesBiochemicalBioinformaticsBiological AssayBloodBreedingCardiometabolic DiseaseCecumCesarean sectionChromosomal InsertionClinicClinicalClostridiumColony-forming unitsCommunitiesComplexDerivation procedureDoseEngineeringEnrollmentEnsureFecesFoodGenerationsGenesGeneticGenetic EngineeringGerm-FreeGnotobioticGoalsHarvestHuman EngineeringHuman ResourcesIn VitroIndividualInfrastructureIntestinesMaintenanceMetabolicMethodsMicrobeModelingMusNutrientOrganismPathway interactionsPerformancePhenotypeRampResearch PersonnelResearch Project GrantsResourcesRoleSamplingServicesSourceTestingTimeTissuesTransplantationUniversitiesUrineWaterWorkbacterial communitycardiometabolismcost effectivedesigndisease phenotypeexperimental studygain of functiongenetic manipulationgut microbiotain vivoloss of functionmembermicrobialmouse modelmutantprogramsreconstitutionsample collectiontraining projectvalidation studies
项目摘要
Microbial Engineering and Transplantation Core (Core C). ABSTRACT:
The overall goals of the Microbial Engineering and Transplantation Core are to maintain and develop
bacterial strains, including model synthetic communities, and provide complex polymicrobial
communities for transplantation, as well as to assist in all aspects of gnotobiotic reconstitution
(microbial transplantation) studies for Project Investigators. All projects in this PPG involve
transplantation of native or genetically manipulated bacterial species, either singly, as polymicrobial
communities, and/or synthetic bacterial communities harboring selective metabolite-producing capabilities (or
functional deletion mutants) into germ-free mice (i.e. gnotobiotic reconstitution). Anaerobic culturing and
microbial engineering, as well as germ-free mouse derivation, maintenance, and microbial transplantation, are
all complex features of intricate experiments that require specialized expertise, and infrastructure. The
Microbial Engineering and Transplantation Core will provide all of these services to investigators of this PPG.
The microbial culturing and engineering component of the Core will assist investigators with centralized
anaerobic culturing capabilities for both in vitro metabolic/biochemical, and in vivo microbial transplantation
studies. Each Project will also draw on this core for its expertise and assistance with genetic engineering of
human commensals as needed. The gnotobiotics component of this core will assist all Projects in performance
of gnotobiotic reconstitution studies, and their interface with cardiometabolic phenotyping studies (in Core D).
微生物工程和移植核心(核心C)。摘要:
微生物工程和移植核心的总体目标是保持和发展
细菌菌株,包括模型合成社区,并提供复杂的多微生物
社区的移植,以及协助各方面的gnotobiotic重建
(微生物移植)研究。本PPG中的所有项目均涉及
移植天然或遗传操作的细菌物种,无论是单独的,作为多微生物
群落和/或具有选择性代谢物产生能力的合成细菌群落(或
功能缺失突变体)转化到无菌小鼠中(即无菌重建)。厌氧培养和
微生物工程,以及无菌小鼠的衍生、维持和微生物移植,
复杂实验的所有复杂特征都需要专门的专业知识和基础设施。的
微生物工程和移植中心将为本PPG的研究者提供所有这些服务。
核心的微生物培养和工程组件将协助研究人员集中
用于体外代谢/生物化学和体内微生物移植的厌氧培养能力
问题研究每个项目还将利用这一核心的专门知识和援助,
需要的人的身体该核心的gnotobiotics成分将有助于所有项目的性能
gnotobiotic重建研究,及其与心脏代谢表型研究的接口(核心D)。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ADELINE M HAJJAR其他文献
ADELINE M HAJJAR的其他文献
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{{ truncateString('ADELINE M HAJJAR', 18)}}的其他基金
Core C: Microbial Engineering and Transplantation Core
核心 C:微生物工程和移植核心
- 批准号:
10206252 - 财政年份:2019
- 资助金额:
$ 21.74万 - 项目类别:
Core C: Microbial Engineering and Transplantation Core
核心 C:微生物工程和移植核心
- 批准号:
10653047 - 财政年份:2019
- 资助金额:
$ 21.74万 - 项目类别:
Development of humanized TLR4 SNP mouse models
人源化TLR4 SNP小鼠模型的开发
- 批准号:
8837077 - 财政年份:2014
- 资助金额:
$ 21.74万 - 项目类别:
Development of humanized TLR4 SNP mouse models
人源化TLR4 SNP小鼠模型的开发
- 批准号:
8701498 - 财政年份:2014
- 资助金额:
$ 21.74万 - 项目类别:
TLR-Based Adjuvant Development in Non-Human Primates
非人灵长类动物基于 TLR 的佐剂开发
- 批准号:
7639068 - 财政年份:2008
- 资助金额:
$ 21.74万 - 项目类别:
TLR4 and Pulmonary Innate Immunity to P.aeruginosa
TLR4 和肺对铜绿假单胞菌的先天免疫
- 批准号:
6528178 - 财政年份:2001
- 资助金额:
$ 21.74万 - 项目类别:
TLR4 and Pulmonary Innate Immunity to P.aeruginosa
TLR4 和肺对铜绿假单胞菌的先天免疫
- 批准号:
6789299 - 财政年份:2001
- 资助金额:
$ 21.74万 - 项目类别:
TLR4 and Pulmonary Innate Immunity to P.aeruginosa
TLR4 和肺对铜绿假单胞菌的先天免疫
- 批准号:
6442681 - 财政年份:2001
- 资助金额:
$ 21.74万 - 项目类别:
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