Understanding how cortex supports flexible sensory representations

了解皮层如何支持灵活的感觉表征

• 批准号: 10448054
• 负责人: Katherine Charlotte Wood
• 金额: $ 12.43万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-04 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10448054
• 关键词: Acetylcholine; Area; Auditory area; Behavior; Behavioral; Brain; Cannulas; Cell Nucleus; Cells; Chronic; Cues; Dependovirus; Disease; Earplug; Electrophysiology (science); Environment; Exhibits; Feedback; Fiber; Goals; Grant; Hearing; Hearing Aids; Implant; Individual; Inferior Colliculus; Ipsilateral; Learning; Light; Linear Models; Location; Measures; Methods; Mus; Neurons; Optics; Pathway interactions; Patient Education; Patients; Perception; Phase; Photometry; Population; Presbycusis; Property; Quality of life; Research; Role; Sensory; Sensory Aids; Side; Signal Transduction; Sound Localization; Source; Stimulus; Synapses; Techniques; Testing; Training; Unilateral Hearing Loss; Viral; Visual; Weight; auditory feedback; calcium indicator; cholinergic; density; experience; flexibility; hearing impairment; improved; normal hearing; novel; optical fiber; optogenetics; receptive field; relating to nervous system; sensory input; sound

Project Summary Learning is a fundamental function of the brain: sensory representations must be flexible to adjust to changes in environmental demands and experience, thus allowing us to adapt to the world around us. Understanding the mechanisms of learning are important not only for normal function of the brain but also in disease, for example, after unilateral hearing loss. One important but often overlooked principle of learning is the importance of feedback from other brain areas. In this grant I propose to investigate the function of corticofugal feedback, from auditory cortex (ACx) to inferior colliculus (IC), in sound localization learning after unilateral hearing loss. I will test (1) the hypothesis that the function of cortico-collicular feedback is to provide information about the current sensory conditions using optogenetics and behavior; and (2) the hypothesis that acetylcholine (ACh) release in ACx modulates activity in IC during learning, using fiber photometry to record ACh release dynamics in ACx and neural activity in IC simultaneously. In the independent phase, I will test (3) the hypothesis that burst activity in feedback from ACx to IC contains an error signal which directs plasticity in IC and leads to behavioral adaptation to the new listening environment using electrophysiology and opto-tagging in ACx and IC. Understanding the mechanisms by which the brain compensates for changes in sensory input can provide information about how to best develop treatments, such as hearing and other sensory aids, or perceptual training for patients who experience such losses, thus improving their ability to communicate and quality of life.

项目总结