Effects of DLPFC tDCS on Cognition, Oscillations and GABA Levels in Schizophrenia

DLPFC tDCS 对精神分裂症认知、振荡和 GABA 水平的影响

• 批准号: 10448414
• 负责人: Cameron S. Carter
• 金额: $ 66.46万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-12 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10448414
• 关键词: Address; Adult; Affect; Anodes; Area; Attention; Behavioral Paradigm; Brain; Cognition; Cognitive deficits; Data; Development; Disease; Dose; Economic Burden; Electrophysiology (science); Equilibrium; Expectancy; Failure; Functional disorder; Goals; Human; Impaired cognition; Impairment; Individual; Intuition; Link; Literature; Magnetic Resonance Spectroscopy; Maintenance; Measures; Mediation; Mental disorders; Meta-Analysis; Methods; Modeling; National Institute of Mental Health; Occipital lobe; Occupational; Outcome; Pattern; Performance; Prefrontal Cortex; Process; Research; Rest; Role; Schizophrenia; Site; Specificity; Task Performances; Techniques; Testing; Time; Work; base; brain circuitry; cognitive control; cognitive disability; cognitive neuroscience; cognitive performance; cognitive task; daily functioning; design; effective therapy; efficacy testing; electric field; frontal lobe; gamma-Aminobutyric Acid; improved; insight; neural network; neuroimaging; neuromechanism; noninvasive brain stimulation; psychotic symptoms; relating to nervous system; social; support network; therapy development; tool

PROJECT SUMMARY/ABSTRACT Cognitive control deficits are associated with poor functioning in schizophrenia (SZ). These deficits include an impaired ability to maintain task-relevant goals and attention to a task over time, and are connected to impaired functioning of the dorsolateral prefrontal cortex (DLPFC), a key hub in the neural network supporting cognitive control. The proposed research uses a non-invasive brain stimulation technique, transcranial direct current stimulation (tDCS) to test a set of mechanistic hypotheses about the role of the DLPFC in cognitive control deficits in SZ, focusing on stimulation-induced changes in neural oscillations and DLPFC GABA levels. To do so, we will use DLPFC-targeted tDCS in combination with electrophysiology (EEG) and magnetic resonance spectroscopy (MRS) methods to examine stimulation-induced changes in neural activity related to cognitive control in SZ. Preliminary data from our lab suggests that DLPFC-targeted anodal tDCS can enhance neural oscillations that support goal maintenance in both healthy controls and individuals with SZ. This neurostimulation approach offers an exciting new avenue for understanding the neural mechanisms underlying impaired cognition in SZ, which we propose to utilize with three specific aims. Aim 1: Compare the effects of task-engaged versus resting tDCS in order to optimize the impact of tDCS on goal maintenance related neural oscillatory activity and task performance in SZ. Aim 2: Establish the regional specificity of the impact of DLPFC tDCS (compared to Occipital tDCS) effects on brain circuitry underlying goal maintenance in SZ. Aim 3: Test hypotheses about relationships between tDCS effects on DLPFC GABA levels, DLPFC-related oscillatory activity and cognitive performance in SZ. Successful completion of these Aims will address critical gaps in the literature on cognitive disability in SZ, which has, to date, relied on correlative approaches and will provide new insights into the role of disrupted DLPFC related brain circuity in SZ and its underlying pathophysiological mechanisms. It will also provide important new insights into the mechanisms of tDCS effects on brain and cognition in this illness.

项目总结/文摘