Training in the Design and Development of Infectious Disease Therapeutics

传染病治疗药物设计和开发培训

基本信息

  • 批准号:
    10447715
  • 负责人:
  • 金额:
    $ 22.32万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-07-08 至 2026-06-30
  • 项目状态:
    未结题

项目摘要

Project Summary/Abstract Infectious diseases remain the leading cause of death of children worldwide. New therapeutics are urgently needed to replace current treatments that are being compromised by drug resistance and emerging threats. The current COVID-19 pandemic perfectly illustrates the urgency. St. Jude Children’s Research Hospital (SJCRH) is the ideal pediatric research and treatment center to train postdoctoral fellows in this effort. The hospital’s translational and collaborative research environment combined with its expertise and infrastructure have a proven track record of successful therapeutic development. Our pediatric patients, particularly those treated for cancer, are typically immunocompromised and are at risk from a wide variety of infectious agents and pathogens that evolve more rapidly without immune clearance. SJCRH has developed an internationally recognized infectious disease program that dates from its establishment over 50 years ago. This program includes major research efforts in therapeutic and prophylactic strategies for bacterial, viral and fungal infectious agents. The training program leverages these strengths and the strong history of developing new therapeutics to provide unique and enhanced research training to postdoctoral fellows. The 16 preceptors in the program are from the departments of Infectious Diseases, Structural Biology, Chemical Biology & Therapeutics, Immunology and Pharmaceutical Sciences. They bring complementary expertise to this enterprise that not only seeks to understand the biology of infection but also strives to develop therapies to combat them. This expertise includes drug discovery, high-throughput screening, medicinal chemistry, immune responses to infection and therapies, and vaccine platforms and adjuvants. These efforts are linked to on-site best in class capabilities in GMP manufacturing and clinical trials. The broad goals of the program are to characterize pathogenic mechanisms, identify targets for therapeutic intervention, and develop vaccines and lead drug compounds that progress through the state-of-the-art therapeutics development infrastructure into safe and effective medicines. Collaborations between the preceptors provide a cross-disciplinary approach to the training program. In addition, 4 clinical collaborators will provide training in patient care, clinical trials and international medicine, and 5 training collaborators will provide training in specialized techniques. All trainees will be instructed in grant writing, rigor and reproducibility, ethics and mentoring. Interactions with pharmaceutical companies and visits to international sites in conjunction with the SJCRH Global Program are integral parts of the curriculum. To promote independence, trainees will develop their own research projects guided by a ‘team’ of mentors and apply for independent funding. We request support for three postdoctoral trainees, and the program will continue its efforts to recruit URM trainees by providing institutional support for an additional URM trainee. Finally, a formal evaluation process led by an External Advisory Committee has been established to track success and identify areas for improvement.
项目总结/摘要 传染病仍然是全世界儿童死亡的主要原因。新的治疗方法迫切需要 需要取代目前因耐药性和新出现的威胁而受到损害的治疗方法。 当前的COVID-19疫情充分说明了这一紧迫性。圣裘德儿童研究医院 (SJCRH)是理想的儿科研究和治疗中心,以培养博士后研究员在这方面的努力。的 医院的转化和协作研究环境结合其专业知识和基础设施 有成功的治疗开发的良好记录。我们的儿科患者,尤其是那些 接受过癌症治疗的患者,通常免疫功能低下,并面临各种感染因子的风险 以及没有免疫清除就进化得更快的病原体。SJCRH开发了一个国际化的 它是一个公认的传染病项目,可以追溯到50多年前成立的时候。这个程序 包括细菌、病毒和真菌感染的治疗和预防策略方面的主要研究成果。 传染源培训计划利用这些优势和开发新产品的强大历史, 为博士后研究员提供独特和增强的研究培训。16位导师 该计划来自传染病,结构生物学,化学生物学和 治疗学、免疫学和药物科学。他们带来了互补的专业知识, 该公司不仅寻求了解感染的生物学,而且还努力开发治疗方法, 打击他们。这些专业知识包括药物发现,高通量筛选,药物化学, 对感染和治疗的免疫应答,以及疫苗平台和佐剂。这些努力与 在GMP生产和临床试验方面具有一流的现场能力。该计划的广泛目标 是描述致病机制,确定治疗干预的靶点,并开发 疫苗和先导药物化合物通过最先进的治疗方法 发展基础设施,转化为安全有效的药物。导师之间的合作 为培训计划提供跨学科的方法。此外,4名临床合作者将提供 病人护理、临床试验和国际医学方面的培训,5名培训合作者将提供 专业技术培训。所有学员将在赠款写作,严谨性和可重复性,道德指导 和指导。与制药公司的互动以及与联合国有关机构一起访问国际地点 SJCRH全球计划是课程的组成部分。为了促进独立性,学员将 在导师“团队”的指导下开发自己的研究项目,并申请独立的资金。我们 请求支持三名博士后培训生,该计划将继续努力招募URM培训生 为额外的城市资源管理受训人员提供机构支助。最后,一个正式的评估过程, 已成立外部咨询委员会,以跟踪成功情况并确定需要改进的领域。

项目成果

期刊论文数量(0)
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Richard E. Lee其他文献

EVALUATION OF GLYCEROL AND DIMETHYL SULFOXIDE FOR THE CRYOPRESERVATION OF SPERMATOZOA FROM THE WOOD FROG (RANA SYLVATICA)
甘油和二甲基亚砜对林蛙 (RANA SYLVATICA) 精子冷冻保存的评价
  • DOI:
  • 发表时间:
    1998
  • 期刊:
  • 影响因子:
    0
  • 作者:
    J. A. Mugnano;J. P. Costanzo;Sara G. Beesley;Richard E. Lee
  • 通讯作者:
    Richard E. Lee
Carotid blood flow and pathogenesis of cerebral ischaemia
颈动脉血流与脑缺血的发病机制
The Bulbar Conjunctival Vascular Bed in Normal Pregnancy
  • DOI:
    10.1016/s0002-9378(16)38683-5
  • 发表时间:
    1953-04-01
  • 期刊:
  • 影响因子:
  • 作者:
    Robert Landesman;Gordon Douglas;Georgene Dreishpoon;Richard E. Lee
  • 通讯作者:
    Richard E. Lee
Ultrastructural effects of lethal freezing on brain, muscle and Malpighian tubules from freeze-tolerant larvae of the gall fly, Eurosta solidaginis.
致命冷冻对耐冻胆蝇幼虫脑、肌肉和马氏小管的超微结构影响。
  • DOI:
    10.1016/s0022-1910(96)00073-x
  • 发表时间:
    1997
  • 期刊:
  • 影响因子:
    2.2
  • 作者:
    Stephen D Collins;A. Allenspach;Richard E. Lee
  • 通讯作者:
    Richard E. Lee
An approach to combinatorial library generation of galactofuranose mimics as potential inhibitors of mycobacterial cell wall biosynthesis: Synthesis of a peptidomimetic of uridine 5′-diphosphogalactofuranose (UDP-Galf)
呋喃半乳糖模拟物作为分枝杆菌细胞壁生物合成潜在抑制剂的组合文库生成方法:尿苷 5′-二磷酸半乳呋喃糖肽模拟物的合成 (UDP-Galf)
  • DOI:
  • 发表时间:
    1999
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Richard E. Lee;Martin D. Smith;L. Pickering;G. Fleet
  • 通讯作者:
    G. Fleet

Richard E. Lee的其他文献

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{{ truncateString('Richard E. Lee', 18)}}的其他基金

Spectinomycin analogs for NTM infections
用于 NTM 感染的壮观霉素类似物
  • 批准号:
    10471892
  • 财政年份:
    2020
  • 资助金额:
    $ 22.32万
  • 项目类别:
Spectinomycin analogs for NTM infections
用于 NTM 感染的壮观霉素类似物
  • 批准号:
    10265604
  • 财政年份:
    2020
  • 资助金额:
    $ 22.32万
  • 项目类别:
Spectinomycin analogs for NTM infections
用于 NTM 感染的壮观霉素类似物
  • 批准号:
    10673801
  • 财政年份:
    2020
  • 资助金额:
    $ 22.32万
  • 项目类别:
Training in the Design and Development of Infectious Disease Therapeutics
传染病治疗药物设计和开发培训
  • 批准号:
    10617855
  • 财政年份:
    2015
  • 资助金额:
    $ 22.32万
  • 项目类别:
Development of Aminospectinomycins for Biodefense
用于生物防御的氨基大观霉素的开发
  • 批准号:
    8860114
  • 财政年份:
    2014
  • 资助金额:
    $ 22.32万
  • 项目类别:
Development of Aminospectinomycins for Biodefense
用于生物防御的氨基大观霉素的开发
  • 批准号:
    9291410
  • 财政年份:
    2014
  • 资助金额:
    $ 22.32万
  • 项目类别:
Development of Aminospectinomycins for Biodefense
用于生物防御的氨基大观霉素的开发
  • 批准号:
    8693411
  • 财政年份:
    2014
  • 资助金额:
    $ 22.32万
  • 项目类别:
Development of novel proteins synthesis inhibitors for MDR tuberculosis
耐多药结核病新型蛋白质合成抑制剂的开发
  • 批准号:
    8305156
  • 财政年份:
    2010
  • 资助金额:
    $ 22.32万
  • 项目类别:
Development of novel proteins synthesis inhibitors for MDR tuberculosis
耐多药结核病新型蛋白质合成抑制剂的开发
  • 批准号:
    7989056
  • 财政年份:
    2010
  • 资助金额:
    $ 22.32万
  • 项目类别:
Development of novel proteins synthesis inhibitors for MDR tuberculosis
耐多药结核病新型蛋白质合成抑制剂的开发
  • 批准号:
    8495235
  • 财政年份:
    2010
  • 资助金额:
    $ 22.32万
  • 项目类别:

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