Training in the Design and Development of Infectious Disease Therapeutics

传染病治疗药物设计和开发培训

基本信息

  • 批准号:
    10447715
  • 负责人:
  • 金额:
    $ 22.32万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-07-08 至 2026-06-30
  • 项目状态:
    未结题

项目摘要

Project Summary/Abstract Infectious diseases remain the leading cause of death of children worldwide. New therapeutics are urgently needed to replace current treatments that are being compromised by drug resistance and emerging threats. The current COVID-19 pandemic perfectly illustrates the urgency. St. Jude Children’s Research Hospital (SJCRH) is the ideal pediatric research and treatment center to train postdoctoral fellows in this effort. The hospital’s translational and collaborative research environment combined with its expertise and infrastructure have a proven track record of successful therapeutic development. Our pediatric patients, particularly those treated for cancer, are typically immunocompromised and are at risk from a wide variety of infectious agents and pathogens that evolve more rapidly without immune clearance. SJCRH has developed an internationally recognized infectious disease program that dates from its establishment over 50 years ago. This program includes major research efforts in therapeutic and prophylactic strategies for bacterial, viral and fungal infectious agents. The training program leverages these strengths and the strong history of developing new therapeutics to provide unique and enhanced research training to postdoctoral fellows. The 16 preceptors in the program are from the departments of Infectious Diseases, Structural Biology, Chemical Biology & Therapeutics, Immunology and Pharmaceutical Sciences. They bring complementary expertise to this enterprise that not only seeks to understand the biology of infection but also strives to develop therapies to combat them. This expertise includes drug discovery, high-throughput screening, medicinal chemistry, immune responses to infection and therapies, and vaccine platforms and adjuvants. These efforts are linked to on-site best in class capabilities in GMP manufacturing and clinical trials. The broad goals of the program are to characterize pathogenic mechanisms, identify targets for therapeutic intervention, and develop vaccines and lead drug compounds that progress through the state-of-the-art therapeutics development infrastructure into safe and effective medicines. Collaborations between the preceptors provide a cross-disciplinary approach to the training program. In addition, 4 clinical collaborators will provide training in patient care, clinical trials and international medicine, and 5 training collaborators will provide training in specialized techniques. All trainees will be instructed in grant writing, rigor and reproducibility, ethics and mentoring. Interactions with pharmaceutical companies and visits to international sites in conjunction with the SJCRH Global Program are integral parts of the curriculum. To promote independence, trainees will develop their own research projects guided by a ‘team’ of mentors and apply for independent funding. We request support for three postdoctoral trainees, and the program will continue its efforts to recruit URM trainees by providing institutional support for an additional URM trainee. Finally, a formal evaluation process led by an External Advisory Committee has been established to track success and identify areas for improvement.
项目总结/文摘

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Richard E. Lee其他文献

EVALUATION OF GLYCEROL AND DIMETHYL SULFOXIDE FOR THE CRYOPRESERVATION OF SPERMATOZOA FROM THE WOOD FROG (RANA SYLVATICA)
甘油和二甲基亚砜对林蛙 (RANA SYLVATICA) 精子冷冻保存的评价
  • DOI:
  • 发表时间:
    1998
  • 期刊:
  • 影响因子:
    0
  • 作者:
    J. A. Mugnano;J. P. Costanzo;Sara G. Beesley;Richard E. Lee
  • 通讯作者:
    Richard E. Lee
Carotid blood flow and pathogenesis of cerebral ischaemia
颈动脉血流与脑缺血的发病机制
The Bulbar Conjunctival Vascular Bed in Normal Pregnancy
  • DOI:
    10.1016/s0002-9378(16)38683-5
  • 发表时间:
    1953-04-01
  • 期刊:
  • 影响因子:
  • 作者:
    Robert Landesman;Gordon Douglas;Georgene Dreishpoon;Richard E. Lee
  • 通讯作者:
    Richard E. Lee
Ultrastructural effects of lethal freezing on brain, muscle and Malpighian tubules from freeze-tolerant larvae of the gall fly, Eurosta solidaginis.
致命冷冻对耐冻胆蝇幼虫脑、肌肉和马氏小管的超微结构影响。
  • DOI:
    10.1016/s0022-1910(96)00073-x
  • 发表时间:
    1997
  • 期刊:
  • 影响因子:
    2.2
  • 作者:
    Stephen D Collins;A. Allenspach;Richard E. Lee
  • 通讯作者:
    Richard E. Lee
An approach to combinatorial library generation of galactofuranose mimics as potential inhibitors of mycobacterial cell wall biosynthesis: Synthesis of a peptidomimetic of uridine 5′-diphosphogalactofuranose (UDP-Galf)
呋喃半乳糖模拟物作为分枝杆菌细胞壁生物合成潜在抑制剂的组合文库生成方法:尿苷 5′-二磷酸半乳呋喃糖肽模拟物的合成 (UDP-Galf)
  • DOI:
  • 发表时间:
    1999
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Richard E. Lee;Martin D. Smith;L. Pickering;G. Fleet
  • 通讯作者:
    G. Fleet

Richard E. Lee的其他文献

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{{ truncateString('Richard E. Lee', 18)}}的其他基金

Spectinomycin analogs for NTM infections
用于 NTM 感染的壮观霉素类似物
  • 批准号:
    10471892
  • 财政年份:
    2020
  • 资助金额:
    $ 22.32万
  • 项目类别:
Spectinomycin analogs for NTM infections
用于 NTM 感染的壮观霉素类似物
  • 批准号:
    10265604
  • 财政年份:
    2020
  • 资助金额:
    $ 22.32万
  • 项目类别:
Spectinomycin analogs for NTM infections
用于 NTM 感染的壮观霉素类似物
  • 批准号:
    10673801
  • 财政年份:
    2020
  • 资助金额:
    $ 22.32万
  • 项目类别:
Training in the Design and Development of Infectious Disease Therapeutics
传染病治疗药物设计和开发培训
  • 批准号:
    10617855
  • 财政年份:
    2015
  • 资助金额:
    $ 22.32万
  • 项目类别:
Development of Aminospectinomycins for Biodefense
用于生物防御的氨基大观霉素的开发
  • 批准号:
    8860114
  • 财政年份:
    2014
  • 资助金额:
    $ 22.32万
  • 项目类别:
Development of Aminospectinomycins for Biodefense
用于生物防御的氨基大观霉素的开发
  • 批准号:
    9291410
  • 财政年份:
    2014
  • 资助金额:
    $ 22.32万
  • 项目类别:
Development of Aminospectinomycins for Biodefense
用于生物防御的氨基大观霉素的开发
  • 批准号:
    8693411
  • 财政年份:
    2014
  • 资助金额:
    $ 22.32万
  • 项目类别:
Development of novel proteins synthesis inhibitors for MDR tuberculosis
耐多药结核病新型蛋白质合成抑制剂的开发
  • 批准号:
    8305156
  • 财政年份:
    2010
  • 资助金额:
    $ 22.32万
  • 项目类别:
Development of novel proteins synthesis inhibitors for MDR tuberculosis
耐多药结核病新型蛋白质合成抑制剂的开发
  • 批准号:
    7989056
  • 财政年份:
    2010
  • 资助金额:
    $ 22.32万
  • 项目类别:
Development of novel proteins synthesis inhibitors for MDR tuberculosis
耐多药结核病新型蛋白质合成抑制剂的开发
  • 批准号:
    8495235
  • 财政年份:
    2010
  • 资助金额:
    $ 22.32万
  • 项目类别:

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用于治疗开发的新型混合细胞群的分析和质量控制
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