Enhancing transdiagnostic mechanisms of cognitive dyscontrol using computer-based training

使用基于计算机的训练增强认知失调的跨诊断机制

• 批准号: 10451615
• 负责人: Jessica Bomyea
• 金额: $ 61.85万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10451615
• 关键词: Address; Adult; Affect; Anxiety; Behavioral; Benchmarking; Brain; Cellular Phone; Clinical; Cognition; Cognitive; Data; Disease; Distress; Dose; E-learning; Environment; Executive Dysfunction; Exercise; Foundations; Frequencies; Functional Magnetic Resonance Imaging; Goals; Individual; Intervention; Knowledge; Memory; Mental Depression; Mission; Modeling; Moods; National Institute of Mental Health; Neurobehavioral Manifestations; Neurobiology; Neurosciences; Outcome; Participant; Performance; Persons; Phase; Population; Post-Traumatic Stress Disorders; Public Health; Randomized; Randomized Controlled Trials; Research; Research Priority; Resources; Role; Sampling; Short-Term Memory; Symptoms; System; Task Performances; Testing; Therapeutic; Thinking; Training; Training Programs; Training Technics; Traumatic Stress Disorders; adverse outcome; associated symptom; base; clinical effect; cognitive enhancement; cognitive function; cognitive performance; cognitive system; cognitive task; cognitive testing; cognitive training; computerized; confirmatory trial; cost; design; disability; emotional functioning; emotional symptom; executive function; experience; improved; innovation; mHealth; mood symptom; negative mood; neuroimaging; novel; portability; primary outcome; psychologic; reduce symptoms; relating to nervous system; rumination; standard care; stem; suicidal risk; tool; treatment program

Mood, anxiety, and traumatic stress disorders are common psychiatric conditions - affecting over 40 million U.S. adults - and are leading causes of disability worldwide. People with these conditions are commonly plagued by difficulty controlling distressing personal thoughts and memories, collectively referred to as repetitive negative thinking symptoms. Models suggest that repetitive negative thinking is driven by executive functioning deficits, such that cognitive resources are insufficient to downregulate unwanted thoughts. Executive functioning deficits could be a promising treatment target but are not typically addressed with existing interventions. The long-term goal advanced by this proposal is to develop effective, mechanistic cognitive training programs that can improve cognition and reduce symptoms associated with mood, anxiety, and traumatic stress disorders. The objectives of this proposal are first to determine the optimal dose of a cognitive training program designed to improve executive functioning in this population using behavioral and neural outcomes (R61). If the cognitive training tested in the R61 successfully improves executive functioning (go/no-go decision), we will evaluate the relationship between change in executive functioning and change in clinical symptoms (R33). Our central hypothesis is that repeated training exercises will enhance executive functioning and will lead to a reduction of repetitive negative thinking in mood, anxiety, and traumatic stress disorders. The hypothesis will be tested by pursing two specific aims: Aim 1 is to identify the cognitive effects and optimal dose of cognitive training. Aim 2 is to evaluate the clinical effects of the optimized cognitive training program relative to a sham condition. We will also conduct an exploratory aim to determine generalization of cognitive training to real-world cognitive performance. The R61 phase will test Aim 1 by randomizing participants with depression, anxiety, and/or traumatic stress disorders to one of two doses of cognitive training or a no-treatment control condition. We will examine executive functioning change with cognitive task performance and functional neuroimaging assessments. The R33 phase will randomize participants to the dose decided by the R61 or a sham condition. The R33 intends to replicate the impact on executive functioning and assess the relationship between change in executive functioning and clinical symptoms. We will explore how cognitive training helps people in their daily lives by including assessments given with a smartphone mobile cognitive testing app. The research proposed is innovative because it aims to address symptoms by intervening on a cognitive target thought to generate symptoms across multiple disorders, thus explicitly testing the interactions of cognitive and emotional symptoms. Outcomes derived from the proposed research will include a novel treatment program and information about its utility for reducing clinical symptoms. Knowledge from this proposal will advance our treatment options by targeting a specific cognitive system, providing a foundation for neuroscience-based therapeutic alternative for symptoms that span mood, anxiety, and traumatic stress disorders.

情绪、焦虑和创伤性应激障碍是常见的精神疾病，影响着超过4000万美国人

项目成果

Prospective relations between anxiety sensitivity and transdiagnostic anxiety following cognitive-behavioral therapy: Evidence from the Coordinated Anxiety Learning management trial.

认知行为治疗后焦虑敏感性与跨诊断焦虑之间的前瞻性关系：来自协调焦虑学习管理试验的证据。

• DOI: 10.1016/j.brat.2022.104119
• 发表时间: 2022
• 期刊: Behaviour research and therapy
• 影响因子: 4.1
• 作者: Hunt,Christopher;Campbell-Sills,Laura;Chavira,Denise;Craske,Michelle;Sherbourne,Cathy;Sullivan,Greer;Roy-Byrne,Peter;Stein,MurrayB;Bomyea,Jessica
• 通讯作者: Bomyea,Jessica

Examining Individual Differences in the Within-Person Process of Perceived Stress and Cognitive Functioning to Advance Precision Health: Commentary on "Sex Differences in the Relationship between Perceived Stress and Cognitive Trajectories" by Paolillo et

检查感知压力和认知功能的个体差异以促进精准健康：对 Paolillo 等人的“感知压力与认知轨迹之间关系的性别差异”的评论

• DOI: 10.1016/j.jagp.2023.01.018
• 发表时间: 2023
• 期刊: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
• 作者: Moore,RaeanneC;Henneghan,AshleyM
• 通讯作者: Henneghan,AshleyM