Evaluating a novel working memory training program to decrease symptoms of PTSD

评估一种新的工作记忆训练计划以减少 PTSD 症状

• 批准号: 8197806
• 负责人: Jessica Bomyea
• 金额: $ 3.02万
• 依托单位: SAN DIEGO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8197806
• 关键词: Accounting; Affect; Aftercare; Amber; American; American Psychiatric Association; Amygdaloid structure; Anxiety; Applications Grants; Area; Attention; Award; Biometry; Burn injury; Characteristics; Chronic; Clinical Research; Cognition; Cognitive; Cognitive Science; Cognitive deficits; Complement; Computers; Disease; Distress; Educational process of instructing; Emotional; Event; Extinction (Psychology); Fright; Functional Magnetic Resonance Imaging; Future; Generalized Anxiety Disorder; Generations; Goals; Individual; Intervention; Interviewer; Knowledge; Laboratories; Laboratory Research; Lead; Learning; Length; Life; Link; Literature; Maintenance; Mediating; Memory; Mental Depression; Methodology; Methods; Modification; Monitor; National Institute of Mental Health; Neurobiology; Obsessive-Compulsive Disorder; Participant; Patient Self-Report; Performance; Pharmacological Treatment; Play; Post-Traumatic Stress Disorders; Preparation; Procedures; Process; Program Effectiveness; Publications; Randomized; Relative (related person); Reporting; Research; Research Training; Role; Secondary to; Short-Term Memory; Social Phobia; Stimulus; Strategic Planning; Symptoms; Task Performances; Testing; Theoretical model; Thinking; Training; Training Programs; Training Technics; Trauma; Treatment outcome; Update; Woman; Work; base; career; cognitive control; cognitive training; cost; cost effective; depressive symptoms; design; disorder control; economic cost; effective therapy; executive function; experience; health care service utilization; improved; innovation; neural circuit; neuropsychological; novel; novel strategies; operation; primary outcome; programs; psychosocial; public health relevance; response; secondary outcome; sexual assault; skills; social; suicidal risk

DESCRIPTION (provided by applicant): Post-traumatic stress Disorder (PTSD) is a chronic and debilitating disorder that affects millions of people each year (Kessler et al., 2005). Although effective psychosocial and pharmacological treatments exist for this disorder, as many as 50 percent of individuals still experience symptoms after treatment (Schottenbaeur et al., 2008). Empirical literature suggests that cognitive deficits may play a role in maintaining symptoms in individuals with PTSD through a variety of mechanisms, including decreased cognitive control over intrusive thoughts (Verwoerd et al., in press) and dysregulation in neural circuitry linking prefrontal cognitive control functions and amygdala activity (McNally, 2007). The goals of the proposed research are to improve the candidate's understanding of cognitive mechanisms of PTSD symptoms while building skills in conducting treatment research. The application aims to test a novel methodology for approaching PTSD treatment based on modification of underlying cognitive mechanisms of the disorder. To this end, 50 participants with PTSD will be randomly assigned to an 8-session executive control training condition designed to improve working memory functioning or a control condition. The aims of this study are 1) To test the effect of a working memory training program on working memory performance and 2) To examine the effects of this program on PTSD symptoms. The research plan is complemented by a set of training goals for the candidate to achieve over the proposed award period. These include 1) training in the use of fMRI and neuropsychological assessment 2) additional coursework and seminars in cognitive science and biostatistics for use in future work, 3) experience with teaching in the undergraduate and graduate setting and presenting original work for publication in preparation for a career in academic research. Taken together, the research and training components of this grant application will facilitate the candidate's long-term goal of conducting treatment outcome and basic mechanism research in PTSD. Moreover, as per the strategic plan outlined by NIMH, this application is designed develop an innovative intervention based on prior clinical research and knowledge of cognitive and neurobiological features of the disorder, and will advance knowledge of mechanisms of fear learning. It is designed to target core cognitive features of the disorder in an effort to reduce symptoms. PUBLIC HEALTH RELEVANCE: Post-traumatic stress disorder impacts millions of Americans, and is associated with significant personal distress as well as societal cost. The current application is designed to examine the effect of a novel working memory training program on PTSD symptoms. This approach is promising in that it may be a cost- effective and accessible method for decreasing symptoms associate with this disorder.

描述（由申请人提供）：创伤后应激障碍（PTSD）是一种慢性且使人衰弱的疾病，每年影响数百万人（Kessler等人，2005年）。尽管对于这种疾病存在有效的心理社会和药理学治疗，但多达50%的个体在治疗后仍然经历症状（Schottenbaeur等人，2008年）。经验文献表明，认知缺陷可能通过多种机制在PTSD个体中维持症状中发挥作用，包括对侵入性想法的认知控制降低（Verwoerd et al.，在出版）和神经回路的失调连接前额叶认知控制功能和杏仁核活动（麦克纳利，2007年）。拟议研究的目标是提高候选人对PTSD症状的认知机制的理解，同时建立进行治疗研究的技能。该申请旨在测试一种新的方法，用于基于对该疾病的潜在认知机制的修改来接近PTSD治疗。为此，50名患有PTSD的参与者将被随机分配到旨在改善工作记忆功能的8节执行控制训练条件或控制条件。本研究的目的是：1）测试工作记忆训练计划对工作记忆表现的影响; 2）检查该计划对PTSD症状的影响。研究计划由一系列培训目标补充，供候选人在拟议的奖励期内实现。这些包括1）培训使用功能磁共振成像和神经心理学评估2）额外的课程和研讨会在认知科学和生物统计学在未来的工作中使用，3）在本科生和研究生设置教学经验，并提出原创作品出版准备在学术研究生涯。总的来说，这项资助申请的研究和培训部分将促进候选人的长期目标，即进行创伤后应激障碍的治疗结果和基本机制研究。此外，根据NIMH概述的战略计划，该应用程序旨在根据先前的临床研究以及对该疾病的认知和神经生物学特征的了解开发创新干预措施，并将促进对恐惧学习机制的了解。它旨在针对该疾病的核心认知特征，以减轻症状。 公共卫生相关性：创伤后应激障碍影响着数百万美国人，并与重大的个人痛苦和社会成本有关。当前的应用程序旨在检查一种新的工作记忆训练计划对PTSD症状的影响。这种方法是有前途的，因为它可能是一种成本有效和可获得的方法，用于减少与这种疾病相关的症状。