Training in Multi-scale Analysis of Biological Structure and Function

项目摘要 这是NIBIB生物结构多尺度分析研究生培训计划的更新 和功能在加州圣地亚哥大学。博士前培训生完全来自一个 正式的跨学科博士多尺度生物学专业化（“接口研究生培训 计划”），其中包括来自10个高排名参与家庭博士的学生。程序（生物工程， 生物科学、生物医学科学、化学和生物化学、机械和航空航天 工程，神经科学和物理，材料科学与工程，化学工程和 自2015年加入Nanoengineering）。学生在研究生学习的第一年结束时申请。T32 该计划汇集了40名培训教师，并支持24名学生在本期来自生物 科学（2），健康科学（9），工程（5）和物理科学（8）。它的目标是培养一个新的干部 科学家谁可以跨越学科界限，以解决重要的生物医学问题，跨越规模， 从分子到有机体的生物组织。到目前为止，已有44名Interfaces学生毕业。13人 在这辆T32上训练城市登记管理代表增加到29% 培训课程的一个核心特点是七个动手研究生实验室课程， 向学生介绍在生物学尺度上测量和分析生命系统的先进技术 从分子到整个有机体。学生使用最先进的设施， 从质谱到电子显微镜和磁共振成像技术。科学 对生物结构和功能的多尺度分析的关注反映了现代生物学的一个基本挑战。 生物医学科学在开发和应用新的定量方法，从物理，工程， 生物科学和健康科学与生物医学中的综合问题。常规活动，包括 每两周一次的研究生研讨会，年度研讨会和务虚会，课程开放日和季度计划 会议，促进来自不同学科的学生和教师之间的互动。双导师 培训计划成功地促进了重要领域的新的跨学科合作，包括 发育生物学、神经科学和癌症、心血管疾病、诊断和药物发现。 这一更新申请建议继续培养最多样化的学生团体成为有效的领导者， 生物功能的结构集成多尺度分析。它将开发一个新的数据实验室课程 科学多尺度生物学，创建一个新的校友导师网络的学员和结构化的 为未来的学生提供共同指导的跨学科研究轮换。

Project Summary This is a renewal of an NIBIB Graduate Training Program in ​Multi-Scale Analysis of Biological Structure and Function at the University of California San Diego. Pre-doctoral trainees are drawn exclusively from a formal ​Interdisciplinary Ph.D. specialization in Multi-Scale Biology (the “Interfaces Graduate Training Program”), which includes students from 10 highly ranked participating home Ph.D. programs (Bioengineering, Biological Sciences, Biomedical Sciences, Chemistry and Biochemistry, Mechanical and Aerospace Engineering, Neurosciences and Physics, with Materials Science & Engineering, Chemical Engineering and Nanoengineering joining since 2015). Students apply at the end of their first year of graduate studies. This T32 program brings together 40 training faculty and supported 24 students in the current period are from Biological Sciences (2), Health Sciences (9), Engineering (5) and Physical Sciences (8). It’s goal is to train a new cadre of scientist who can cross disciplinary boundaries to solve important biomedical problem that span scales of biological organization from molecule to organism. To date 44 Interfaces students have graduated. 13 were trainees on this T32. URM representation increased to 29% A central feature of the training curriculum is seven hands-on graduate laboratory courses that introduce students to advanced techniques for measuring and analyzing living systems ​at scales of biological organization spanning from molecule to whole organism​. Students use state-of-the-art facilities and technologies from mass spectrometry to electron microscopy and magnetic resonance imaging. The scientific focus on multi-scale analysis of biological structure and function reflects a fundamental challenge of modern biomedical science in developing and applying novel quantitative approaches from the physical, engineering, biological and health sciences to integrative problems in biomedicine. Regular program activities, including bi-weekly graduate seminars, annual symposia and retreats, course open houses and quarterly program meetings, promote interactions between students and faculty from different disciplines. The dual-mentored training program is successful in promoting new interdisciplinary collaborations in important areas including developmental biology, neuroscience and cancer, cardiovascular disease, diagnostics and drug discovery. This renewal application proposes to continue to train the most diverse student body to be effective leaders in structurally integrated multi-scale analysis of biological function. It will develop a new lab course in Data Sciences for Multiscale Biology, create a new Alumni Mentor Network for trainees and a structured co-mentored interdisciplinary research rotation for prospective students.