SIMULATION OF CORONARY ARTERY BYPASS GRAFT AND SURGICAL VENTRICULAR RESTORATION

冠状动脉搭桥术和心室修复手术的模拟

• 批准号: 8362806
• 负责人: Andrew D. McCulloch
• 金额: $ 2万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362806
• 关键词: Anatomy; Biomedical Computing; Blood flow; Cardiac; Cardiovascular Diseases; Computer software; Coronary Artery Bypass; Coronary artery; Funding; Grant; Heart failure; Magnetic Resonance Imaging; Myocardial Ischemia; National Center for Research Resources; Operative Surgical Procedures; Patients; Physics; Postoperative Period; Principal Investigator; Public Domains; Research; Research Infrastructure; Research Personnel; Resources; Simulate; Software Tools; Source; Surgeon; United States National Institutes of Health; Ventricular; base; cost; restoration; simulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall objective of this project is to develop and deploy a public-domain software tool that will enable cardiac surgeons and cardiovascular disease researchers to simulate the effects of coronary artery bypass graft (CABG) and surgical ventricular restoration (SVR) on patients with ischemic heart failure. The aims are to: 1. Obtain pre- and post-operative CT and MRI exams on STICH patients (n = 10) in order to quantify their LV wall geometry and regional function and coronary artery anatomy and blood flow. 2. Develop physics-based simulations of CABG and SVR using only public-domain software. Hypothesis: There is a benefit of SVR + CABG over CABG alone in the treatment of patients with ischemic heart failure.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 该项目的总体目标是开发和部署公共领域 软件工具将使心脏外科医生和心血管疾病研究人员能够 模拟冠状动脉旁路移植术 (CABG) 和手术心室的效果 缺血性心力衰竭患者的恢复（SVR）。目标是： 1. 按顺序获取 STICH 患者 (n = 10) 的术前和术后 CT 和 MRI 检查 量化他们的左室壁几何形状和区域功能以及冠状动脉解剖结构和 血流（量。 2. 仅使用公共领域软件开发基于物理的 CABG 和 SVR 模拟。 假设：在治疗患者方面，SVR + CABG 比单独 CABG 更有益处 患有缺血性心力衰竭。