Training in Multi-Scale Analysis of Biological Structure and Function

描述(由申请者提供)：为了帮助培养一支能够跨越医学、生物、物理和工程科学之间的学科界限的跨学科研究科学家队伍，拟议的研究培训计划将支持十名博士前学生在加州大学圣迭戈分校新设立的多尺度生物学跨学科博士学位专业的第二和第三年攻读博士学位。该专业的学生属于生物科学、健康科学、物理科学和雅各布斯工程学院的五个成熟和排名很高的研究生课程之一(生物工程、生物医学、生物科学和神经科学)。培训课程的一个独特特点是六门专门的动手实验室课程，涉及专门技术(包括质谱学、光学和电子显微镜、磁共振成像和高性能计算)，用于测量和分析从分子到整个生物体的生物组织的多个尺度上的生物结构和功能。对生物结构和功能的多尺度分析的科学关注反映了现代生物医学科学的根本挑战和来自18个系的37个项目教员(包括3名HHMI调查人员和1名MAS成员)的优势 (英国生物科学、物理科学和健康科学、医学院或药学院，斯卡格斯药学和制药科学学院的两名新教员)开发和应用从生物化学、细胞生物学、生物光子学、显微镜、组织工程、成像和计算建模的新方法，以解决生物医学中跨越分子到整个生物体尺度的综合问题。双导师培训计划在这些领域提供了优秀的跨学科研究生研究机会，特别是与人类遗传学、发育和癌症、神经、心血管和肌肉骨骼系统的疾病和障碍、诊断和治疗学有关的研究机会。研究生培训计划还提供了高度跨学科的培训环境和丰富的活动，以促进新的跨学科合作和互动。 相关性：现代生物医学最重要的科学挑战需要详细了解分子水平上的生物过程如何在细胞、组织、器官和全身水平上产生功能。该计划培养工程、物理科学、生物科学和健康科学之间的研究生，使他们能够应用现代技术应对这些挑战。

DESCRIPTION (provided by applicant): To help train a cadre of interdisciplinary research scientists who can cross disciplinary boundaries between medical, biological, physical and engineering sciences, the proposed research training program will support ten pre-doctoral students during their second and third years of doctoral study in a newly established interdisciplinary Ph.D. degree Specialization in Multi-Scale Biology at UCSD. Students in the specialization belong to one of five established and highly ranked graduate programs (Bioengineering, Biomedical Sciences, Biological Sciences and Neurosciences) from the Divisions of Biological Sciences, Health Sciences, Physical Sciences and the Jacobs School of Engineering. A unique feature of the training curriculum is six specialized hands-on laboratory courses in specialized technologies (including mass spectrometry, light and electron microscopy, magnetic resonance imaging and high-performance computing) for measuring and analyzing biological structures and functions across multiple scales of biological organization from molecular to whole organism. The scientific focus on multi-scale analysis of biological structure and function reflects a fundamental challenge of modern biomedical science and the strengths of the 37 program faculty (with three HHMI Investigators and one member of the MAS) from 18 departments (Eng., Biological Sciences., Physical Sciences and Health Sciences, Schools of Medicine or Pharmacy, with two new faculty from the Skaggs School of Pharmacy and Pharmaceutical Sciences) in developing and applying novel approaches from biochemistry, cell biology, biophotonics, microscopy, tissue engineering, imaging and computational modeling to integrative problems in biomedicine spanning the molecular to whole organism scales. The dual-mentored training program provides outstanding interdisciplinary graduate research opportunities in these areas, especially in relation to human genetics, development and cancer, diseases and disorders of the nervous, cardiovascular, and musculoskeletal systems, diagnostics and therapeutics. The graduate training program also provides a highly interdisciplinary training environment and a wealth of activities to promote new interdisciplinary collaborations and interactions. RELEVANCE: Most important scientific challenges of modern biomedicine require a detailed understanding of how biological processes at the molecular scale give rise to functions at the levels of the cell, tissue, organ and whole body. This program trains graduate students at the interfaces between engineering, physical sciences, biological sciences and health sciences to apply modern technologies to these challenges.