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Neotropical Primate Reagent Resource

新热带灵长类试剂资源

基本信息

批准号：
10450091
负责人：
Kathleen Engelman
金额：
$ 56.53万
依托单位：
UNIV OF MASSACHUSETTS MED SCH WORCESTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10450091
关键词：
Address Affinity African Aging Animal Disease Models Animal Model Animals Antibodies Antibody Response Area Asian Basic Science Biological Biological Markers Biomedical Research CD8B1 gene Callithrix Callithrix jacchus jacchus Cell surface Cells Clinical Communicable Diseases Development Disease Disease model Engineering Funding Generations Genetic Polymorphism Goals IgG Receptors Immune Immune Targeting Immune response Immune system Immunoglobulin A Immunoglobulin G Immunoglobulin M Immunoglobulins Immunologics Inflammatory Lymphocyte Depletion Lymphocyte Subset MS4A1 gene Mediator of activation protein Metabolic Diseases Modeling Modification Monoclonal Antibodies Neurodegenerative Disorders Population Primates Reagent Recovery Research Research Contracts Research Personnel Resources Rodent Saimiri Surface Antigens Testing Time Transgenic Animals Translational Research United States National Institutes of Health antibody diagnostic cross reactivity drug development exhaustion in vivo interest nonhuman primate novel therapeutics novel vaccines receptor tool

项目摘要

Summary Nonhuman primates (NHPs) have historically served as crucial animal models for diseases, and for testing of new therapies and vaccines that cannot be evaluated in rodents. Neotropical primates are used in biomedical research less frequently in the U.S. than Old World primates, but there is growing interest in these animals as models due to the close recapitulation of certain clinical diseases and simpler husbandry considerations. Studies involving marmosets and squirrel monkeys comprise the bulk of NIH-funded research featuring neotropical primates in several areas, including neurodegenerative disorders, infectious diseases, and aging. In this resource application, we propose to develop a number of marmoset and squirrel monkey antibodies to address the gap between project goals and available reagents. Species-matched antibodies can deplete targeted lymphocyte subsets and allow investigators to probe the impact of specific immune populations on progression, protection, and recovery. Diagnostic antibodies that distinguish antibody classes and subclasses, cell surface biomarkers, and soluble mediators will reduce limitations imposed by poor reagent accessibility. To derive these reagents, the squirrel monkey and marmoset immunoglobulin and Fcg receptor repertoire will be exhaustively defined and characterized. The antibody resources described here can raise the bar on neotropical primate translational research by providing investigators validated tools to evaluate the immune response in models of infectious or inflammatory disease.

总结