ELLIPSS: ELucidating the Landscape of Immunoendotypes in Psoriatic Skin and Synovium

ELLIPSS：阐明银屑病皮肤和滑膜的免疫内型概况

• 批准号: 10451910
• 负责人: Johann Eli Gudjonsson
• 金额: $ 110万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-21 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10451910
• 关键词: Advertising; Affect; Aftercare; Autoimmune; Award; Bioinformatics; Biopsy; Blood; Cell Communication; Cells; Chronic small plaque psoriasis; Clinical Data; Clinical Protocols; Cohort Studies; Collaborations; Collection; Common Data Element; Communication; Consult; Coupled; Cues; Data; Data Collection; Dermatologist; Development; Disease; Disease Pathway; Elderly; Electronic Health Record; Enrollment; Exclusion Criteria; Fostering; Funding Opportunities; Genetic; Goals; Human Resources; Immune; Immunologics; Immunologist; Immunology; Individual; Inflammation; Joints; Knowledge; Knowledge Portal; Leadership; Link; Lupus; Manuscripts; Measures; Mediating; Medicine; Michigan; Molecular; Molecular Analysis; Molecular Profiling; Participant; Pathogenicity; Pathologist; Pathology; Patient Recruitments; Patient-Focused Outcomes; Patients; Personnel Management; Phenotype; Physicians; Pilot Projects; Proteomics; Protocols documentation; Psoriasis; Psoriatic Arthritis; Quality Control; Research Personnel; Resolution; Rheumatoid Arthritis; Sampling; Science; Scientist; Site; Skin; Standardization; Structure; Synovial Membrane; Systemic Lupus Erythematosus; Systems Biology; Technology; Testing; Tissue Banks; Tissue Sample; Tissues; Training; United States; Universities; Work; biomarker identification; cell type; chronic pain; clinical phenotype; clinically relevant; cohort; data sharing; disease phenotype; ethnic diversity; gut microbiome; improved outcome; joint inflammation; joint injury; lipidomics; loss of function; microbial; microbiome; multidisciplinary; multiple omics; new therapeutic target; oral microbiome; participant enrollment; phenotypic data; programs; racial and ethnic; recruit; repository; rheumatologist; sample collection; scale up; skin microbiome; statistics; success; synergism; tissue processing; transcriptomics; treatment response

ABSTRACT Psoriatic Spectrum Diseases (PSD) affect over 8 million individuals in the U.S. living with psoriasis (PsO) or psoriatic arthritis (PsA) and encompass heterogeneous phenotypes of disease, ranging from plaque, guttate, palmoplantar, inverse, pustular, and erythrodermic forms of psoriasis, to synovial, enthesial, and axial forms of PsA. Here, we assembled a world class multidisciplinary team of scientists in PSD cohort assembly, clinical phenotyping, biosample acquisition, pathology, statistics, and bioinformatics, for the Accelerating Medicines Partnership Autoimmune and Immune-Mediated Diseases (AMP AIM) PSD Disease Teams (DTs). The major scientific goals of the PSD DT are to understand the cellular and molecular composition of distinct PSD endotypes and how they link with phenotypes, to identify how key pathogenic or regulatory cells spatially interact with each other and with environmental cues (i.e., microbiome), and to define at a single-cell level how the transition to PsA unfolds in the setting of PsO. To accomplish the goals of the PSD AMP, we propose the creation of the ELLIPSS (ELucidating the Landscape of Immunoendotypes in Psoriatic Skin and Synovium) Disease Team (DT). The AIMS of the ELLIPSS Team are to 1) to enroll diverse PSD cohorts and perform clinical phenotyping, data capture, and tissue collection. 2) to implement an effective management plan for the ELLIPSS multidisciplinary team. 3) to optimize interface of ELLIPSS team with AMP-AIM network. Lastly, a robust Opportunities Fund (OF) management program is proposed under the direction and leadership of Dr. James T. Elder at University of Michigan. The ELLIPSS PSD DT will efficiently integrate with the AMP AIM Network, facilitate collection of PSD biosamples, and help provide an unprecedented view of cell types and states, along with spatial and tissue interactions (skin, joint, blood, microbiome) to deconstruct/reconstruct the psoriatic disease spectrum.

抽象的 银屑病频谱疾病（PSD）影响了美国牛皮癣（PSO）或 银屑病关节炎（PSA）和疾病的异质表型，范围从斑块，胆量 牛皮癣的棕榈，逆，脓疱和红皮性形式，用于滑膜，触发和轴向形式的形式 PSA。在这里，我们组建了一个世界一流的多学科小组，科学家在PSD队列组装中，临床 表型，生物样品获取，病理，统计和生物信息学，用于加速药物 伴侣自身免疫和免疫介导的疾病（AMP AIM）PSD疾病小组（DTS）。 PSD DT的主要科学目标是了解不同的细胞和分子组成 PSD内型及其与表型的联系，以确定钥匙致病细胞的空间方式 彼此相互作用以及环境提示（即微生物组），并在单细胞级别定义如何 向PSA的过渡在PSO的环境中展开。为了实现PSD放大器的目标，我们建议 创建椭圆的创建（阐明银屑病和滑膜中免疫原样的景观） 疾病小组（DT）。椭圆团队的目的是1）注册多样的PSD队列并进行临床 表型，数据捕获和组织收集。 2）为椭圆实施有效的管理计划 多学科团队。 3）通过AMP-AIM网络优化椭圆团队的接口。最后，一个健壮的人 机会基金（）管理计划是在詹姆斯·T博士的指导和领导下提出的。 密歇根大学的长者。 Ellipss PSD DT将有效地与AMP AIM网络集成，促进PSD生物样本的收集， 并有助于提供细胞类型和状态的前所未有的视图，以及空间和组织相互作用（皮肤， 关节，血液，微生物组）以解构/重建银屑病疾病谱。