Neurostimulation and Recording of Real World Spatial Navigation in Humans

人类真实世界空间导航的神经刺激和记录

• 批准号: 10452606
• 负责人: NANTHIA A SUTHANA
• 金额: $ 107.47万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10452606
• 关键词: Address; Alzheimer' s Disease; Animals; Area; Augmented Reality; Basic Science; Behavior; Behavioral; Brain; Chiroptera; Chronic; Clinical; Clinical Sciences; Clinical Treatment; Cognitive; Collaborations; Coupling; Deep Brain Stimulation; Development; Devices; Disease; Electrodes; Electroencephalography; Electrophysiology (science); Environment; Epilepsy; Eye; Eye Movements; Foundations; Functional Magnetic Resonance Imaging; Future; Head Movements; Hippocampus (Brain); Human; Impairment; Implant; Learning; Location; Measurement; Measures; Medial; Memory; Memory Disorders; Memory impairment; Methodology; Methods; Morphologic artifacts; Motion; Movement; Nature; Neurons; Neurosciences; Participant; Patients; Pattern; Performance; Physiology; Positioning Attribute; Prevalence; Protocols documentation; Research; Rodent; Role; Route; Scientist; Source Code; Stimulus; Structure; System; Technology; Temporal Lobe; Testing; Therapeutic; Time; Virtual and Augmented reality; body position; brain research; gray matter; innovation; insight; neuroimaging; neuromechanism; neurophysiology; next generation; nonhuman primate; novel; open source; programs; research clinical testing; research study; spatial memory; theories; translational study; virtual reality; visual tracking; walking speed; way finding; wearable device; white matter; wireless

Project Summary/Abstract Decades of research and clinical observations have established that successful spatial navigation and memory depend on the hippocampus and associated structures in the medial temporal lobe (MTL), including entorhinal, perirhinal and parahippocampal cortices [1, 2]. It is thought that the supporting neuronal mechanisms rely on key oscillatory patterns of activity within the MTL that change dynamically when navigating through an environment [3-10]. However, traditional human neuroimaging methodologies do now allow for recording of MTL oscillatory activity during spatial navigation let alone physical movement. The proposed project will implement a first-of-its- kind platform for wireless deep brain recording and stimulation of MTL oscillatory activity during freely moving behaviors to investigate the relationship between spatial navigation, memory, and oscillatory activity, using intracranial electroencephalographic (iEEG) recordings in participants who are implanted with the Neuropace Responsive Neurostimulator (RNS®) for clinical evaluation and treatment of epilepsy. The RNS device will allow for the stimulation and recording of MTL iEEG activity during virtual reality (VR), augmented reality (AR), and real world (RW) spatial navigation tasks with simultaneous recording full-body and eye position and movement using wearable technologies. Together these studies will have access to 70 rare participants implanted with the RNS system over the project period through an ongoing multi-institutional collaboration among clinical and basic science leaders at UCLA, Stanford, and UCSF. Since our studies address basic questions about the role of oscillations in memory, the results will allow for the bridging of findings between species and lay the scientific foundation for helping future patients with diseases where memory is impaired such as Alzheimer’s disease and epilepsy.

项目总结/摘要 几十年的研究和临床观察已经证实，成功的空间导航和记忆 依赖于海马体和内侧颞叶（MTL）中的相关结构，包括内嗅， 嗅周和海马旁皮质[1，2]。据认为，支持神经元机制依赖于关键的 当在环境中导航时，MTL内动态变化的振荡活动模式 [3-10]。然而，传统的人类神经成像方法现在确实允许记录MTL振荡信号。 空间导航时的活动，更不用说身体运动了。该项目将实施其第一个- 一种用于自由运动时MTL振荡活动无线脑深部记录和刺激的平台 行为来研究空间导航，记忆和振荡活动之间的关系，使用 植入Neuropace的受试者的颅内脑电图（iEEG）记录 用于临床评估和治疗癫痫的反应性神经刺激器（RNS®）。RNS装置将允许 用于在虚拟现实（VR）、增强现实（AR）和 真实的世界（RW）空间导航任务，同时记录全身和眼睛的位置和运动 使用可穿戴技术。总之，这些研究将有机会获得70名罕见的参与者， RNS系统在项目期间通过临床和基础之间的持续多机构合作 加州大学洛杉矶分校、斯坦福大学和加州大学旧金山分校的科学领袖。由于我们的研究解决了关于 在记忆的振荡，结果将允许物种之间的发现桥梁，奠定了科学 基金会帮助未来的病人，其中记忆受损的疾病，如阿尔茨海默氏症， 癫痫