Neurostimulation and Recording of Real World Spatial Navigation in Humans

项目摘要/摘要 几十年的研究和临床观察已经证实，成功的空间导航和记忆 依赖于海马体和内侧颞叶(MTL)的相关结构，包括内嗅觉， 海马周和海马旁皮质[1，2]。据认为，支持神经元的机制依赖于键 在环境中导航时动态更改的MTL内的活动振荡模式 [3-10]。然而，传统的人类神经成像方法现在确实允许记录MTL振荡 空间导航期间的活动，更不用说身体运动了。拟议的项目将实施首个ITS- 一种无线脑深部记录和刺激自由运动时MTL振荡活动的平台 研究空间导航、记忆和振荡活动之间关系的行为，使用 植入神经起搏的受试者的颅内脑电记录 用于癫痫临床评估和治疗的反应性神经刺激器(RNS®)。RNS设备将允许 在虚拟现实(VR)、增强现实(AR)期间刺激和记录MTL iEEG活动，以及 同时记录全身和眼睛位置和运动的真实世界(RW)空间导航任务 使用可穿戴技术。这些研究总共将有70名罕见的参与者被植入 通过临床和基础医疗机构之间持续的多机构合作，在项目期间建立RNS系统 加州大学洛杉矶分校、斯坦福大学和加州大学旧金山分校的科学领袖。因为我们的研究解决了关于 记忆中的振荡，结果将允许在物种之间架起发现的桥梁，并奠定科学 帮助未来患有记忆受损疾病的患者的基金会，如阿尔茨海默氏症和 癫痫。

Project Summary/Abstract Decades of research and clinical observations have established that successful spatial navigation and memory depend on the hippocampus and associated structures in the medial temporal lobe (MTL), including entorhinal, perirhinal and parahippocampal cortices [1, 2]. It is thought that the supporting neuronal mechanisms rely on key oscillatory patterns of activity within the MTL that change dynamically when navigating through an environment [3-10]. However, traditional human neuroimaging methodologies do now allow for recording of MTL oscillatory activity during spatial navigation let alone physical movement. The proposed project will implement a first-of-its- kind platform for wireless deep brain recording and stimulation of MTL oscillatory activity during freely moving behaviors to investigate the relationship between spatial navigation, memory, and oscillatory activity, using intracranial electroencephalographic (iEEG) recordings in participants who are implanted with the Neuropace Responsive Neurostimulator (RNS®) for clinical evaluation and treatment of epilepsy. The RNS device will allow for the stimulation and recording of MTL iEEG activity during virtual reality (VR), augmented reality (AR), and real world (RW) spatial navigation tasks with simultaneous recording full-body and eye position and movement using wearable technologies. Together these studies will have access to 70 rare participants implanted with the RNS system over the project period through an ongoing multi-institutional collaboration among clinical and basic science leaders at UCLA, Stanford, and UCSF. Since our studies address basic questions about the role of oscillations in memory, the results will allow for the bridging of findings between species and lay the scientific foundation for helping future patients with diseases where memory is impaired such as Alzheimer’s disease and epilepsy.