Neurostimulation and Recording of Real World Spatial Navigation in Humans

人类真实世界空间导航的神经刺激和记录

• 批准号: 10665617
• 负责人: NANTHIA A SUTHANA
• 金额: $ 106.7万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10665617
• 关键词: Address; Alzheimer' s Disease; Animals; Area; Augmented Reality; Basic Science; Behavior; Behavioral; Brain; Chiroptera; Chronic; Clinical; Clinical Sciences; Clinical Treatment; Cognitive; Collaborations; Coupling; Deep Brain Stimulation; Development; Devices; Disease; Electrodes; Electroencephalography; Electrophysiology (science); Environment; Epilepsy; Eye; Eye Movements; Foundations; Functional Magnetic Resonance Imaging; Future; Head Movements; Hippocampus; Human; Impairment; Implant; Institution; Learning; Location; Measurement; Measures; Medial; Memory; Memory Disorders; Memory impairment; Methodology; Methods; Morphologic artifacts; Motion; Movement; Nature; Neurons; Neurosciences; Participant; Patients; Pattern; Performance; Physiology; Positioning Attribute; Prevalence; Protocols documentation; Research; Rodent; Role; Route; Scientist; Source Code; Stimulus; Structure; System; Technology; Temporal Lobe; Testing; Therapeutic; Time; Virtual and Augmented reality; body position; brain research; gray matter; innovation; insight; neuroimaging; neuromechanism; neurophysiology; next generation; nonhuman primate; novel; open source; programs; research clinical testing; research study; spatial memory; theories; translational study; virtual; visual tracking; walking speed; way finding; wearable device; white matter; wireless

Project Summary/Abstract Decades of research and clinical observations have established that successful spatial navigation and memory depend on the hippocampus and associated structures in the medial temporal lobe (MTL), including entorhinal, perirhinal and parahippocampal cortices [1, 2]. It is thought that the supporting neuronal mechanisms rely on key oscillatory patterns of activity within the MTL that change dynamically when navigating through an environment [3-10]. However, traditional human neuroimaging methodologies do now allow for recording of MTL oscillatory activity during spatial navigation let alone physical movement. The proposed project will implement a first-of-its- kind platform for wireless deep brain recording and stimulation of MTL oscillatory activity during freely moving behaviors to investigate the relationship between spatial navigation, memory, and oscillatory activity, using intracranial electroencephalographic (iEEG) recordings in participants who are implanted with the Neuropace Responsive Neurostimulator (RNS®) for clinical evaluation and treatment of epilepsy. The RNS device will allow for the stimulation and recording of MTL iEEG activity during virtual reality (VR), augmented reality (AR), and real world (RW) spatial navigation tasks with simultaneous recording full-body and eye position and movement using wearable technologies. Together these studies will have access to 70 rare participants implanted with the RNS system over the project period through an ongoing multi-institutional collaboration among clinical and basic science leaders at UCLA, Stanford, and UCSF. Since our studies address basic questions about the role of oscillations in memory, the results will allow for the bridging of findings between species and lay the scientific foundation for helping future patients with diseases where memory is impaired such as Alzheimer’s disease and epilepsy.

项目总结/文摘