Eradicating bacterial biofilms with nitroxide-antimicrobial hybrids

用硝基氧-抗菌剂混合物根除细菌生物膜

• 批准号: DP210101317
• 负责人: Prof Kathryn Fairfull-Smith
• 金额: $ 32.9万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-12-01 至 2025-11-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210101317
• 关键词: Eradicating; bacterial; biofilms; nitroxide; antimicrobial

This project aims to develop new antimicrobials to address the rise of drug-resistant infections and resilient bacterial communities called biofilms. We aim to break new ground in our fundamental knowledge of antimicrobial mechanisms and exploit this understanding by fusing cellular/molecular microbiology and synthetic chemistry approaches. We seek to gain an in-depth understanding of how nitroxides induce bacterial biofilm dispersal, which is critical for the discovery of anti-biofilm molecules that do not fail due to resistance development. These breakthroughs should induce a step-change in our ability to reduce the occurrence of biofilm-related infection in fields ranging from medical and veterinary to biotechnology and agriculture.

该项目旨在开发新的抗菌剂，以解决耐药感染和被称为生物膜的弹性细菌群落的上升问题。我们的目标是在抗菌机制的基础知识上取得新的突破，并通过融合细胞/分子微生物学和合成化学方法来利用这种理解。我们试图深入了解氮氧化物如何诱导细菌生物膜扩散，这对于发现抗生物膜分子至关重要，这些分子不会因耐药性的发展而失败。这些突破将导致我们在从医学和兽医到生物技术和农业等领域减少生物膜相关感染发生的能力逐步发生变化。