Untangling the matrix of bacterial biofilms

解开细菌生物膜的基质

• 批准号: DP230101930
• 负责人: Prof Mark Schembri
• 金额: $ 33.22万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-07-07 至 2026-07-06
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230101930
• 关键词: Untangling; matrix; bacterial; biofilms

This research aims to use forefront molecular microbiology and biophysical approaches to advance fundamental knowledge on bacterial biofilms. These bacterial clusters are held together by an extracellular matrix comprised of bacterial-derived fibrous protein and the polysaccharide cellulose, which imparts structural integrity and resistance to antimicrobials. The major goals of this project are to dissect how bacteria regulate production of the biofilm matrix, and examine how changes in the composition of the matrix alters its properties, including the penetration of antimicrobial peptides and antibiotics. The outcomes will help address the economic burden of difficult to treat industrial, environmental and biomedical biofilms.

本研究旨在利用最前沿的分子微生物学和生物物理学方法来推进细菌生物膜的基础知识。这些细菌簇通过由细菌衍生的纤维蛋白和多糖纤维素组成的细胞外基质保持在一起，其赋予结构完整性和对抗菌剂的抗性。该项目的主要目标是剖析细菌如何调节生物膜基质的产生，并研究基质组成的变化如何改变其性质，包括抗菌肽和抗生素的渗透。这些成果将有助于解决难以处理的工业、环境和生物医学生物膜的经济负担。