权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

The Influence of Gonadal Hormones on Opioid Use

性腺激素对阿片类药物使用的影响

基本信息

批准号：
10455011
负责人：
Mark A Smith
金额：
$ 32.7万
依托单位：
DAVIDSON COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-30 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10455011
关键词：
Abstinence Adverse event Androgens Behavior Biological Factors Chronic Clinical Research Cocaine Data Development Drug abuse Drug usage Epidemic Estradiol Estrogens Estrous Cycle Estrus Exhibits Female Gender Goals Gonadal Hormones Health Heroin Hormonal Hormones Intake Intervention Laboratory Rat Literature Measures Mediating Menstrual cycle Mental Depression Methamphetamine Modeling Morphine Opiate Addiction Opioid Ovarian Ovarian hormone Ovariectomy Pattern Pharmaceutical Preparations Phase Pilot Projects Primates Procedures Proestrus Progesterone Public Health Rattus Relapse Reporting Research Rodent Role Self Administration Series Sex Differences Steroids Stimulant Substance Use Disorder System Testosterone Time United States Woman antagonist base cocaine self-administration craving drug abuse vulnerability drug of abuse drug seeking behavior drug sensitivity endogenous opioids epidemiology study falls heroin use inhibitor male men novel opioid abuse opioid use opioid use disorder preclinical study proliferative phase Menstrual cycle receptor sex substance use

项目摘要

PROJECT SUMMARY Preclinical, clinical, and epidemiological studies have consistently revealed sex- and gender-related differences in substance use and the development of substance use disorders. Many of these sex differences can be attributed to gonadal hormones, and the effects of ovarian hormones across the estrous/menstrual cycle have been well documented for cocaine, methamphetamine, and other stimulants. Far fewer studies have examined the role of androgen hormones on drug sensitivity, and relatively few studies have examined the role of ovarian hormones on the self-administration of heroin and other opioids. This represents a limitation of the existing literature, given evidence that gonadal hormones alter sensitivity to the abuse-related effects of opioids in a manner very differently from the way they alter sensitivity to the effects of stimulants. The scientific objective of the proposed project is to characterize the effects of ovarian and androgen hormones on heroin self-administration in sexually mature male and female rats, while identifying hormonally based treatment interventions for opioid use disorders. To this end, Aim 1 will examine the effects of exogenous estradiol, progesterone, and their combination on heroin self-administration in gonadectomized male and female rats. Aim 2 will examine the role of endogenous ovarian hormones in the suppression of heroin self-administration during proestrus through receptor-selective antagonists. Aim 3 will examine the effects of exogenous estradiol and progesterone on heroin self-administration in gonadally intact female rats. Aim 4 will examine the effects of exogenous testosterone on heroin self-administration in gonadectomized male and female rats. Finally, Aim 5 will examine the effects of an androgen steroid inhibitor on heroin self-administration in gonadally intact male rats. The ultimate goal of these studies is to better predict sex-related differences in opioid use disorders and to identify novel and sex-specific treatment interventions for opioid abuse and addiction.

项目总结