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Social and Enviromental Influences on Opioid Sensitivity

社会和环境对阿片类药物敏感性的影响

基本信息

批准号：
7845339
负责人：
Mark A Smith
金额：
$ 6.68万
依托单位：
DAVIDSON COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2010-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7845339
关键词：
Academic Research Enhancement Awards Address Adolescence Adolescent Animal Model Animals Area Behavior Cocaine Companions Consumption Dependence Development Dose Drug Delivery Systems Drug abuse Drug usage Enrollment Equipment Feedback Female Food Funding Home environment Housing Human Illicit Drugs Individual Infusion procedures Intravenous Left Life Measures Methods Modification Movement NIH Program Announcements National Institute of Drug Abuse Operant Conditioning Opioid Parents Pharmaceutical Preparations Play Principal Investigator Radial Rattus Recovery Reporting Research Self Administration Self-Administered Series Sex Characteristics Stainless Steel Students Substance abuse problem System Testing Time United States National Institutes of Health Wages Water college critical period drug seeking behavior environmental enrichment for laboratory animals experience male novel parent grant prevent protective effect public health relevance research study response social

项目摘要

DESCRIPTION (provided by applicant): This application is in response to NOT-OD-09-058: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications. A major component of drug abuse research involves identifying the social and environmental variables that contribute to an individual's likelihood of developing problems with substance abuse and dependence. In the parent grant to this application (2R15DA014255), we proposed a series of studies examining the effects of social and environmental enrichment on measures of drug selfadministration. Those studies are nearing completion, and here we report that social and environmental enrichment during adolescence decreases responding maintained by a low dose of cocaine in female rats. One problem facing animal models of drug self-administration, especially those examining social and environmental manipulations, is that subjects must be removed from the home environment during testing. Consequently, the immediate effects of social contact cannot be examined on measures of drug self-administration that employ intravenous drug delivery. This represents a significant limitation of animal models, as drug use in humans typically occurs in the presence of others, and the behavior of these other people (i.e., whether or not they are also using drugs) can feedback to influence the drug consumption of the individual. With a few simple modifications to our existing operant conditioning chambers, we can construct a large selfadministration chamber that can also serve as a home cage for two rats. Using this chamber, we can examine drug self-administration in individual rats under conditions in which another rat is continuously present during drug self-administration sessions. Importantly, this arrangement allows us to compare drug self-administration in an animal that has a companion that also has free access to drugs (i.e., a co-user) versus an animal that has a companion without access to drugs (i.e., an abstainer). The primary aim of this project is to examine cocaine self-administration in isolated and socially housed rats, with the important caveat that the socially housed subjects will be living together in the same cage 24 hr/day, including during daily self-administration sessions. As a novel manipulation, we will examine the effects of having a companion that self-administers cocaine versus having a companion that does not self-administer cocaine. A final aim of this project is to examine these manipulations in both male and female rats to determine whether there are sex differences in the effects of social contact on measures of drug self-administration. PUBLIC HEALTH RELEVANCE: Adolescence marks a critical period in development in which individuals are particularly vulnerable to developing problems with substance abuse and dependence. Using an animal model, we will examine the effects of social contact with a companion with access to drugs (i.e., a co-user) versus without access to drugs (i.e., an abstainer) on cocaine self-administration in adolescent rats. We will examine these effects in both males and females to determine whether there are sex differences in the effects of social contact on drug-seeking behavior.

描述（由申请人提供）：本申请是对 NOT-OD-09-058 的回应：NIH 宣布恢复法案资金可用于竞争性修订申请。药物滥用研究的一个主要组成部分涉及确定导致个人出现药物滥用和依赖性问题的可能性的社会和环境变量。在本申请的母基金 (2R15DA014255) 中，我们提出了一系列研究，检验社会和环境丰富对药物自我给药措施的影响。这些研究即将完成，在这里我们报告说，青春期的社会和环境丰富会降低雌性大鼠通过低剂量可卡因维持的反应。药物自我给药动物模型，特别是那些检查社会和环境操纵的动物模型面临的一个问题是，在测试过程中必须将受试者从家庭环境中移走。因此，不能通过采用静脉给药的自我给药措施来检验社会接触的直接影响。这代表了动物模型的一个重大局限性，因为人类吸毒通常发生在其他人在场的情况下，而这些其他人的行为（即，他们是否也使用毒品）可以反馈影响个体的吸毒。通过对现有的操作调节室进行一些简单的修改，我们可以构建一个大型自我管理室，该室也可以用作两只老鼠的家笼。使用该室，我们可以在另一只大鼠在药物自我给药过程中持续存在的情况下检查个体大鼠的药物自我给药情况。重要的是，这种安排使我们能够比较具有也可以自由获得药物的同伴（即共同使用者）的动物与具有无法获得药物的同伴（即戒酒者）的动物的药物自我给药。该项目的主要目的是检查隔离和社会饲养的老鼠的可卡因自我给药情况，但重要的是，社会饲养的受试者将每天 24 小时生活在同一个笼子里，包括在日常自我给药期间。作为一种新颖的操作，我们将研究同伴自行服用可卡因与同伴不服用可卡因的效果。该项目的最终目的是在雄性和雌性大鼠中检查这些操作，以确定社会接触对药物自我给药措施的影响是否存在性别差异。公共卫生相关性：青春期是发育的关键时期，在这个时期，个人特别容易出现药物滥用和依赖性问题。使用动物模型，我们将研究与能够获得毒品的同伴（即共同使用者）和无法获得毒品的同伴（即戒毒者）进行社会接触对青春期大鼠自我服用可卡因的影响。我们将检查男性和女性的这些影响，以确定社会接触对寻求毒品行为的影响是否存在性别差异。