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Social and Enviromental Influences on Opioid Sensitivity

社会和环境对阿片类药物敏感性的影响

基本信息

批准号：
7845339
负责人：
Mark A Smith
金额：
$ 6.68万
依托单位：
DAVIDSON COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2010-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7845339
关键词：
Academic Research Enhancement Awards Address Adolescence Adolescent Animal Model Animals Area Behavior Cocaine Companions Consumption Dependence Development Dose Drug Delivery Systems Drug abuse Drug usage Enrollment Equipment Feedback Female Food Funding Home environment Housing Human Illicit Drugs Individual Infusion procedures Intravenous Left Life Measures Methods Modification Movement NIH Program Announcements National Institute of Drug Abuse Operant Conditioning Opioid Parents Pharmaceutical Preparations Play Principal Investigator Radial Rattus Recovery Reporting Research Self Administration Self-Administered Series Sex Characteristics Stainless Steel Students Substance abuse problem System Testing Time United States National Institutes of Health Wages Water college critical period drug seeking behavior environmental enrichment for laboratory animals experience male novel parent grant prevent protective effect public health relevance research study response social

项目摘要

DESCRIPTION (provided by applicant): This application is in response to NOT-OD-09-058: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications. A major component of drug abuse research involves identifying the social and environmental variables that contribute to an individual's likelihood of developing problems with substance abuse and dependence. In the parent grant to this application (2R15DA014255), we proposed a series of studies examining the effects of social and environmental enrichment on measures of drug selfadministration. Those studies are nearing completion, and here we report that social and environmental enrichment during adolescence decreases responding maintained by a low dose of cocaine in female rats. One problem facing animal models of drug self-administration, especially those examining social and environmental manipulations, is that subjects must be removed from the home environment during testing. Consequently, the immediate effects of social contact cannot be examined on measures of drug self-administration that employ intravenous drug delivery. This represents a significant limitation of animal models, as drug use in humans typically occurs in the presence of others, and the behavior of these other people (i.e., whether or not they are also using drugs) can feedback to influence the drug consumption of the individual. With a few simple modifications to our existing operant conditioning chambers, we can construct a large selfadministration chamber that can also serve as a home cage for two rats. Using this chamber, we can examine drug self-administration in individual rats under conditions in which another rat is continuously present during drug self-administration sessions. Importantly, this arrangement allows us to compare drug self-administration in an animal that has a companion that also has free access to drugs (i.e., a co-user) versus an animal that has a companion without access to drugs (i.e., an abstainer). The primary aim of this project is to examine cocaine self-administration in isolated and socially housed rats, with the important caveat that the socially housed subjects will be living together in the same cage 24 hr/day, including during daily self-administration sessions. As a novel manipulation, we will examine the effects of having a companion that self-administers cocaine versus having a companion that does not self-administer cocaine. A final aim of this project is to examine these manipulations in both male and female rats to determine whether there are sex differences in the effects of social contact on measures of drug self-administration. PUBLIC HEALTH RELEVANCE: Adolescence marks a critical period in development in which individuals are particularly vulnerable to developing problems with substance abuse and dependence. Using an animal model, we will examine the effects of social contact with a companion with access to drugs (i.e., a co-user) versus without access to drugs (i.e., an abstainer) on cocaine self-administration in adolescent rats. We will examine these effects in both males and females to determine whether there are sex differences in the effects of social contact on drug-seeking behavior.

描述（由申请人提供）：本申请是对NOT-OD-09-058的回应：NIH宣布为竞争性修订申请提供恢复法案资金。药物滥用研究的一个主要组成部分是查明导致个人可能出现药物滥用和依赖问题的社会和环境变量。在本申请的母基金（2 R15 DA 014255）中，我们提出了一系列研究，以检查社会和环境富集对药物自我给药措施的影响。这些研究已接近完成，在这里，我们报告说，在青春期的社会和环境丰富减少响应维持低剂量的可卡因在雌性大鼠。药物自我给药的动物模型面临的一个问题，特别是那些研究社会和环境操纵的动物模型，是受试者在测试期间必须远离家庭环境。因此，社会接触的直接影响不能检查的措施，采用静脉给药的药物自我管理。这代表了动物模型的显著局限性，因为人类的药物使用通常发生在其他人存在的情况下，并且这些其他人的行为（即，他们是否也在使用药物）可以反馈以影响个体的药物消耗。通过对现有的操作性条件反射室进行一些简单的修改，我们可以构建一个大型的自我管理室，也可以作为两只大鼠的家笼。使用这个腔室，我们可以检查药物自我管理在个别大鼠的条件下，其中另一只大鼠在药物自我管理会话期间持续存在。重要的是，这种安排使我们能够比较具有伴侣的动物中的药物自我给药，所述伴侣也可以自由获得药物（即，共同使用者）与有同伴但不能获得药物的动物（即，戒酒者）。该项目的主要目的是检查可卡因自我管理在隔离和社会圈养的大鼠，与重要的警告，社会圈养的主题将生活在同一笼24小时/天，包括在日常自我管理会议。作为一种新的操纵，我们将检查有一个同伴，自我管理可卡因与有一个同伴，不自我管理可卡因的影响。本项目的最终目的是检查这些操作在雄性和雌性大鼠，以确定是否有性别差异的影响，社会接触的药物自我管理的措施。公共卫生相关性：青少年是发展的关键时期，在这一时期，个人特别容易出现药物滥用和依赖性问题。使用动物模型，我们将检查与获得药物的同伴（即，共同使用者）与没有获得药物（即，戒断者）对青少年大鼠可卡因自我给药的影响。我们将在男性和女性中检查这些影响，以确定社会接触对寻求药物行为的影响是否存在性别差异。