Sustainable Bioproduction of Lactobionic Acid from Whey-Based Bioprocess and Expansion of Accessible Markets through Biotech Active Ingredients ("BIONICe")

该项目的重点是利用真正的工业废流，或从这些废流中提取的低价值产品的生物价态。一个例子是乳清、乳清渗透物或乳清衍生乳糖的生物价态，尽管乳糖每年生产奶酪和其他乳制品1.8亿至1.9亿吨，但仍然是未被充分利用的自然资源。该项目的重点是加速开发一种基于乳清的可持续生物工艺，用于生产乳糖酸，乳糖酸是一种关键、高效和理想的抗衰老和保湿化妆品成分，在其他一系列不同的市场上也有应用，如食品/制药和化学工业。该项目的成果将是一个具有商业意义的端到端过程，准备在一家选定的Toll制造公司进行第一次技术转让和初步制造试验。目标是主要用于化妆品和个人护理，特别是用于护肤品的环保成分的制造，这使得Activatec能够充分利用化妆品行业不断变化的面貌，这些变化是由快速变化的消费者趋势驱动的，这些趋势包括“有机”、“天然”、“绿色”和“环保”产品标签以及对“发酵化妆品”的兴趣。制造方法简单，与报道的非商业方法一致，但在设计上具有创新性，将允许成功的商业开发。整个方法旨在实现可持续性，利用无害环境的制造方法，包括产品下游回收和提纯所需的方法。预计这项技术也将是灵活的，有可能交叉应用于制造其他相关的特定目标产品和衍生品。

The project is focused on the use of true industrial waste streams, or the bio valorisation of low-value products derived from them. One example would be bio valorisation of whey, whey permeate, or whey derived lactose, which although produced in 180 to 190 million tonnes per annum from the manufacture of cheese and other dairy products, are still poorly exploited natural resources.The focus of this project is an accelerated development of a whey-based, sustainable bioprocess for the manufacture of lactobionic acid, a key, highly efficacious and desirable anti-ageing and moisturising cosmetic ingredient which also has applications in a range of other diverse markets such as Food/Pharma and the chemical industry. The project outcome will be a commercially relevant end-to­ end process ready for first tech transfer and initial manufacturing trials at a selected Toll manufacturing company.Targeting the environmentally sensitive manufacture of ingredients primarily for use in cosmetics and personal care and in particular for use in skincare permits Activatec to fully exploit the changing face of the cosmetics industry driven by the rapidly changing consumer trends towards 'organic'; 'natural' 'green' and 'environmentally sensitive' product labelling and the trending interest in 'fermented cosmetics'The manufacturing approach is simplistic, in line with reported non-commercial methods, but innovative in design which will permit successful commercial exploitation. The whole approach is designed for sustainability utilising environmentally benign manufacturing methods including those required for the downstream recovery and purification of the product. The technology is also expected to be flexible with the potential for cross-application for the manufacture of other related specific target products and derivatives.