Development of high-value chemicals bioproduction integrating metabolic engineering, Design of Experiments and entrepreneurship

结合代谢工程、实验设计和创业精神开发高价值化学品生物生产

• 批准号: 2898855
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2898855
• 关键词: Development; value; chemicals; bioproduction; integrating

The use of genetically engineered strains to biomanufacture chemicals enables direct CO2-to-product systems with vastly superior environmental sustainability (reduced GHGe) and synthesisof isomer(s) with a purity not achieved by traditional chemistry. However, the engineering andoptimization of microbial bioproduction strains (essential components in the development ofbiological manufacturing systems) is time-consuming and costly. Coupled with the uncertainty ofbiological engineering, this leads to higher risk and a lower appetite for investment, makingcommercialisation challenging. To enable SynBio to make a meaningful contribution to theenormous fossil fuel problem, we propose to first commence with higher value beachhead targetproducts and solve current bottlenecks to developing viable solutions.

使用基因工程菌株生产化学品使二氧化碳直接转化为产品的系统具有极高的环境可持续性(减少了温室气体排放)，并合成了具有传统化学无法达到的纯度的同分异构体(S)。然而，设计和优化微生物生物生产菌株(开发生物制造系统的关键组件)是耗时和昂贵的。再加上生物工程的不确定性，这导致了更高的风险和更低的投资胃口，使商业化具有挑战性。为了使SynBio能够为巨大的化石燃料问题做出有意义的贡献，我们建议首先从更高价值的滩头目标产品入手，解决目前开发可行解决方案的瓶颈。