Bioproduction of high-value chemicals from Seaweeds

利用海藻生物生产高价值化学品

• 批准号: 2870117
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2870117
• 关键词: Bioproduction; value; chemicals; Seaweeds

With a predicted global market of >$2 billion and importance to e.g., textiles, adhesives, plastics industries, 3-hydroxypropionate (3-HP) is the world's third most valuable platform chemical. However, current biosynthetic and chemical routes for 3-HP production are too costly or inefficient for industrialscale production. This project aims to develop a cost-effective and low carbon emission microbial biosynthetic route for 3-HP production from algal waste.Molecular genetics will be employed to generate proprietary microbial strains with enhanced bio-3-HP production from abundant metabolites present in farmed macroalgae. Analytical chemistry techniques, e.g. chromatography and mass spectroscopy, will be used to quantify production of this high-value chemical. Growth conditions will be investigated in batch and ultimately in bioreactor settings that optimise bio-3-HP production by the strains generated. Furthermore, a method for 3-HP extraction from the cultured strains will be devised, tested, and optimised.

预计全球市场规模超过20亿美元，在纺织、粘合剂、塑料等行业，3-羟基丙酸酯（3-HP）是世界上第三大最有价值的平台化学品。然而，目前用于3-HP生产的生物合成和化学途径对于工业规模生产来说过于昂贵或效率低下。该项目旨在开发一种低成本、低碳排放的微生物生物合成途径，从藻类废弃物中生产3-HP。该项目将利用分子遗传学方法，从养殖大型藻类中丰富的代谢产物中产生具有增强生物3-HP产量的专有微生物菌株。分析化学技术，如色谱和质谱，将用于量化这种高价值化学品的生产。将分批研究生长条件，并最终在生物反应器设置中研究，以优化所产生菌株的bio-3-HP生产。此外，将设计、测试和优化从培养菌株中提取3-HP的方法。