Investigating neighborhood-environment contributions to midlife risk for dementia

调查邻里环境对中年痴呆风险的影响

• 批准号: 10457188
• 负责人: Aaron Reuben
• 金额: $ 6.93万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10457188
• 关键词: Age; Aging; Air Pollution; Amber; Archives; Birth; Brain; Brain Diseases; Characteristics; Clinical; Cognitive aging; Community Health; Data; Data Linkages; Dementia; Development; Disadvantaged; Disease; Economic Conditions; Educational process of instructing; Educational workshop; Elderly; Ensure; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Health; Exposure to; Fellowship; Future; Genetic; Geroscience; Goals; Grain; Grant; Health; Health Care Sector; Health Psychology; Health behavior; Hypertension; Individual; Inflammation; Intervention; Investigation; Leisures; Life; Link; Longevity; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Mediating; Mentors; Mentorship; Methods; Michigan; Modeling; Neighborhoods; Nerve Degeneration; Neurologic; Neurotoxins; New Zealand; Organ; Outcome; Pathologic; Patient Self-Report; Phase; Phenotype; Physical activity; Play; Policies; Population; Prevention; Psychosocial Assessment and Care; Public Health; Reporting; Research; Research Personnel; Resources; Risk; Risk Factors; Role; Social Conditions; Sports; Structure; Symptoms; System; Techniques; Testing; Time; Training; Training Activity; Universities; Work; Writing; age related; aging brain; base; behavior change; brain health; career; career preparation; cognitive ability; cognitive change; cognitive function; cognitive performance; cognitive testing; cohort; data resource; dementia risk; disorder prevention; evidence base; follow-up; good diet; gray matter; health disparity; high risk; improved; infancy; informant; innovation; insight; member; middle age; modifiable risk; neighborhood disadvantage; neuroimaging; neuropsychiatry; novel; prevent; prospective; psychosocial; skills; social; social stressor; sociodemographics; socioeconomics; stressor; symposium; white matter

PROJECT SUMMARY / ABSTRACT Older adults living in disadvantaged neighborhoods, marked by poor physical, social, and economic conditions, are at elevated risk for dementia regardless of their personal sociodemographic characteristics. It is not yet clear when in the lifespan such risk emerges or through which putative causal mechanisms, if it is indeed causal. The activities proposed in this application will fill key research gaps in environmental health and geroscience through first-ever longitudinal studies of neighborhood characteristics and brain aging in midlife, when it is still possible to intervene to prevent dementia. They will inform the identification of at-risk individuals and significantly advance the evidence base needed for potential neighborhood-level dementia interventions, which could leverage public resources outside the healthcare sector and operate without requiring individual behavior change. Proposed projects will integrate diverse geospatial neighborhood data (housed at Michigan State University) into the four-decade archives of the Dunedin Study of psychosocial health, development, and aging among a population-representative New Zealand-based cohort born in 1972 and followed to midlife. The Dunedin cohort is the only one in the world with fine-grained measures of brain integrity from infancy to midlife, with the latest assessment (age 45) including brain structural and functional antecedents of dementia. Studies will determine: (1) whether individuals living in disadvantaged neighborhoods demonstrate signs of accelerated brain aging by midlife; (2) if specific neighborhood characteristics are uniquely associated with midlife brain- health deficits; and (3) whether pro-degenerative health behaviors and conditions (e.g., low physical activity, hypertension, etc.) and are more common in disadvantaged settings and thus may act as causal meditators. The applicant’s career goal is to become a clinical neuropsychologist and independent academic researcher who conducts public health-oriented research on the degenerative consequences of environmental exposures in the hopes of identifying modifiable risk factors and unique interventions to lower the global burden of brain disease. This fellowship will leverage a multi-university training plan to significantly advance the applicant’s career by allowing him to: (1) enter a PI-role in the Dunedin Study; (2) gain additional training to advance his unique research goals, including in established and cutting-edge methods in geospatial analysis, neurotoxicant assessment, and premorbid modeling of brain aging and dementia; and (3) prepare for an innovative career bridging environmental health and psychology with job-readiness skills in teaching, mentoring, and grant writing and management. Mentored training will occur in psychiatric, geospatial, and environmental epidemiology labs at Duke, Michigan State, and Harvard, supplemented by coursework, workshops, and conferences. The fellowship will ensure the applicant's move to independence for a unique body of work investigating environmental contributions to pathological brain aging, with future steps involving additional data linkage and assessment in older and younger cohorts and at the next assessment phase of the Dunedin Study.

项目概要/摘要 生活在贫困社区的老年人，身体、社会和经济条件较差， 无论其个人社会人口特征如何，患痴呆症的风险都较高。现在还没有 明确这种风险在生命周期中何时出现，或者通过哪种假定的因果机制（如果确实如此） 因果。本申请中提出的活动将填补环境健康和环境方面的关键研究空白 通过对中年邻里特征和大脑衰老的首次纵向研究进行老年科学， 当仍然有可能进行干预以预防痴呆症时。他们将通知高危人群的识别 并显着推进潜在的社区级痴呆症干预措施所需的证据基础， 它可以利用医疗保健部门以外的公共资源，并且无需个人参与即可运作 行为改变。拟议的项目将整合不同的地理空间邻里数据（位于密歇根州） 州立大学）将其纳入但尼丁心理健康、发展和社会研究的四个十年档案中 新西兰 1972 年出生并一直持续到中年的人群的老龄化情况。这 但尼丁队列是世界上唯一一个对从婴儿期到中年的大脑完整性进行细粒度测量的队列， 最新评估（45 岁）包括痴呆症的大脑结构和功能前因。研究 将确定：（1）生活在贫困社区的个人是否表现出加速迹象 中年时大脑老化； (2) 如果特定的邻里特征与中年大脑唯一相关 健康缺陷； (3) 是否存在促退化的健康行为和状况（例如体力活动不足、 高血压等），并且在弱势环境中更为常见，因此可以作为因果冥想者。 申请人的职业目标是成为一名临床神经心理学家和独立学术研究员 世卫组织对环境暴露的退化后果进行公共卫生导向的研究 希望确定可改变的风险因素和独特的干预措施，以减轻全球大脑负担 疾病。该奖学金将利用多所大学的培训计划来显着提高申请人的能力 通过允许他：(1) 在达尼丁研究中担任 PI 角色； (2) 接受额外的培训以提高自己的能力 独特的研究目标，包括地理空间分析、神经毒物等方面的既定和前沿方法 大脑衰老和痴呆症的评估和病前建模； (3) 为创新职业做好准备 将环境健康和心理学与教学、指导和资助方面的就业准备技能联系起来 写作和管理。指导培训将在精神病学、地理空间和环境方面进行 杜克大学、密歇根州立大学和哈佛大学的流行病学实验室，辅以课程作业、研讨会和 会议。该奖学金将确保申请人独立从事独特的工作 研究环境对病理性大脑衰老的影响，未来的步骤涉及更多数据 在较老和较年轻的队列中以及达尼丁研究的下一个评估阶段进行联系和评估。