Investigating neighborhood-environment contributions to midlife risk for dementia

调查邻里环境对中年痴呆风险的影响

• 批准号: 10646205
• 负责人: Aaron Reuben
• 金额: $ 7.16万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10646205
• 关键词: Acceleration; Age; Aging; Air Pollution; Amber; Archives; Birth; Brain; Brain Diseases; Characteristics; Clinical; Cognitive aging; Data; Data Linkages; Dementia; Development; Disadvantaged; Disease; Economic Conditions; Educational process of instructing; Educational workshop; Elderly; Ensure; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Health; Exposure to; Fellowship; Future; Genetic; Geroscience; Goals; Grain; Grant; Health; Health Care Sector; Health behavior; Hypertension; Individual; Inequity; Inflammation; Intervention; Investigation; Leisures; Life; Link; Longevity; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Mediating; Mentors; Mentorship; Methods; Michigan; Modeling; Neighborhoods; Nerve Degeneration; Neurologic; Neurotoxins; New Zealand; Organ; Outcome; Pathologic; Patient Self-Report; Phase; Phenotype; Physical activity; Play; Policies; Population; Prevention; Psychology; Psychosocial Assessment and Care; Public Health; Reporting; Research; Research Personnel; Resources; Risk; Risk Factors; Role; Social Conditions; Sports; Structure; Symptoms; System; Techniques; Testing; Time; Training; Training Activity; Universities; Work; Writing; age related; aging brain; behavior change; brain health; career; career preparation; cognitive ability; cognitive change; cognitive function; cognitive performance; cognitive testing; cohort; data resource; dementia risk; disorder prevention; evidence base; follow-up; good diet; gray matter; health disparity populations; high risk population; improved; infancy; informant; innovation; insight; member; middle age; modifiable risk; neighborhood disadvantage; neuroimaging; neuropsychiatry; novel; prevent; prospective; psychosocial; skills; social; social stressor; sociodemographics; socioeconomics; stressor; symposium; white matter

PROJECT SUMMARY / ABSTRACT Older adults living in disadvantaged neighborhoods, marked by poor physical, social, and economic conditions, are at elevated risk for dementia regardless of their personal sociodemographic characteristics. It is not yet clear when in the lifespan such risk emerges or through which putative causal mechanisms, if it is indeed causal. The activities proposed in this application will fill key research gaps in environmental health and geroscience through first-ever longitudinal studies of neighborhood characteristics and brain aging in midlife, when it is still possible to intervene to prevent dementia. They will inform the identification of at-risk individuals and significantly advance the evidence base needed for potential neighborhood-level dementia interventions, which could leverage public resources outside the healthcare sector and operate without requiring individual behavior change. Proposed projects will integrate diverse geospatial neighborhood data (housed at Michigan State University) into the four-decade archives of the Dunedin Study of psychosocial health, development, and aging among a population-representative New Zealand-based cohort born in 1972 and followed to midlife. The Dunedin cohort is the only one in the world with fine-grained measures of brain integrity from infancy to midlife, with the latest assessment (age 45) including brain structural and functional antecedents of dementia. Studies will determine: (1) whether individuals living in disadvantaged neighborhoods demonstrate signs of accelerated brain aging by midlife; (2) if specific neighborhood characteristics are uniquely associated with midlife brain- health deficits; and (3) whether pro-degenerative health behaviors and conditions (e.g., low physical activity, hypertension, etc.) and are more common in disadvantaged settings and thus may act as causal meditators. The applicant’s career goal is to become a clinical neuropsychologist and independent academic researcher who conducts public health-oriented research on the degenerative consequences of environmental exposures in the hopes of identifying modifiable risk factors and unique interventions to lower the global burden of brain disease. This fellowship will leverage a multi-university training plan to significantly advance the applicant’s career by allowing him to: (1) enter a PI-role in the Dunedin Study; (2) gain additional training to advance his unique research goals, including in established and cutting-edge methods in geospatial analysis, neurotoxicant assessment, and premorbid modeling of brain aging and dementia; and (3) prepare for an innovative career bridging environmental health and psychology with job-readiness skills in teaching, mentoring, and grant writing and management. Mentored training will occur in psychiatric, geospatial, and environmental epidemiology labs at Duke, Michigan State, and Harvard, supplemented by coursework, workshops, and conferences. The fellowship will ensure the applicant's move to independence for a unique body of work investigating environmental contributions to pathological brain aging, with future steps involving additional data linkage and assessment in older and younger cohorts and at the next assessment phase of the Dunedin Study.

项目总结/摘要 生活在弱势社区的老年人，身体、社会和经济条件差， 无论他们的个人社会人口特征如何，患痴呆症的风险都很高。目前尚不 明确在生命周期中，这种风险何时出现或通过何种假定的因果机制出现，如果确实如此， 因果关系本申请中提出的活动将填补环境卫生领域的关键研究空白， 老年科学通过首次纵向研究邻里特征和中年大脑老化， 当它仍然有可能干预以预防痴呆症时。他们将告知识别处于风险中的个人 并显著推进潜在的社区级痴呆症干预所需的证据基础， 它可以利用医疗保健部门以外的公共资源， 行为改变拟议的项目将整合不同的地理空间邻里数据（位于密歇根州 州立大学）进入达尼丁研究的心理社会健康，发展和 在1972年出生并跟踪到中年的具有人口代表性的新西兰队列中进行老龄化。的 达尼丁队列是世界上唯一一个对婴儿到中年的大脑完整性进行精细测量的队列， 最新评估（45岁）包括痴呆症的大脑结构和功能前因。研究 将确定：（1）生活在弱势社区的个人是否表现出加速的迹象 中年大脑老化;（2）如果特定的邻居特征与中年大脑唯一相关， 健康缺陷;以及（3）是否有促退化的健康行为和状况（例如，体力活动少， 高血压等）在弱势环境中更常见，因此可能充当因果冥想者。 申请人的职业目标是成为一名临床神经心理学家和独立的学术研究者 世卫组织对环境暴露的退化后果进行面向公共卫生的研究 希望能够确定可改变的风险因素和独特的干预措施，以降低全球大脑负担， 疾病该奖学金将利用多所大学的培训计划，大大提高申请人的 通过允许他：（1）在达尼丁研究中担任PI角色;（2）获得额外的培训以提高他的职业生涯 独特的研究目标，包括在地理空间分析，神经毒素， 评估，以及大脑老化和痴呆症的发病前建模;以及（3）为创新职业做准备 在教学、指导和资助方面将环境健康和心理学与就业准备技能联系起来 写作和管理。指导培训将发生在精神病学，地理空间和环境 流行病学实验室在杜克，密歇根州立大学和哈佛，辅以课程，研讨会， 两会该奖学金将确保申请人的移动到一个独特的工作机构的独立 研究环境对病理性脑老化的影响，未来的步骤涉及更多的数据 在老年和年轻队列中以及在达尼丁研究的下一个评估阶段进行关联和评估。

项目成果

Association of Public Works Disasters with Substance Use Difficulties: Evidence from Flint, Michigan, Five Years after the Water Crisis Onset.

• DOI: 10.3390/ijerph20237090
• 发表时间: 2023-11-21
• 期刊: International journal of environmental research and public health

Toxicant exposure and the developing brain: A systematic review of the structural and functional MRI literature.

有毒物暴露和大脑发育：结构和功能 MRI 文献的系统回顾。

• DOI: 10.1016/j.neubiorev.2022.105006
• 发表时间: 2023
• 期刊: Neuroscience and biobehavioral reviews
• 影响因子: 8.2
• 作者: Fowler,CarinaH;Bagdasarov,Armen;Camacho,NicolasL;Reuben,Aaron;Gaffrey,MichaelS
• 通讯作者: Gaffrey,MichaelS

Prevalence of Depression and Posttraumatic Stress Disorder in Flint, Michigan, 5 Years After the Onset of the Water Crisis.

• DOI: 10.1001/jamanetworkopen.2022.32556
• 发表时间: 2022-09-01
• 期刊: JAMA NETWORK OPEN
• 影响因子: 13.8
• 作者: Reuben, Aaron;Moreland, Angela;Abdalla, Salma M.;Cohen, Gregory H.;Friedman, Matthew J.;Galea, Sandro;Rothbaum, Alex O.;Schmidt, Michael G.;Vena, John E.;Kilpatrick, Dean G.
• 通讯作者: Kilpatrick, Dean G.

Improving risk indexes for Alzheimer's disease and related dementias for use in midlife.

• DOI: 10.1093/braincomms/fcac223
• 发表时间: 2022
• 期刊: Brain communications
• 影响因子: 4.8

Socioenvironmental Adversity and Adolescent Psychotic Experiences: Exploring Potential Mechanisms in a UK Longitudinal Cohort.

• DOI: 10.1093/schbul/sbad017
• 发表时间: 2023-07-04
• 期刊: Schizophrenia bulletin
• 影响因子: 6.6
• 作者: Newbury JB;Arseneault L;Moffitt TE;Odgers CL;Howe LD;Bakolis I;Reuben A;Danese A;Sugden K;Williams B;Rasmussen LJH;Trotta A;Ambler AP;Fisher HL
• 通讯作者: Fisher HL