Increasing the health equity and population-level impact of a digital therapeutic for smokers with psychiatric illness

提高数字疗法对患有精神疾病的吸烟者的健康公平性和人口影响

• 批准号: 10457176
• 负责人: Roger Vilardaga
• 金额: $ 12.12万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10457176
• 关键词: Abstinence; Address; Adopted; Adoption; Affect; Ancillary Study; Area; Award; Black Populations; Black race; Characteristics; Cigarette; Clinic; Clinical; Clinical Investigator; Clinical Trials; Collaborations; Communities; Control Groups; Counseling; Data; Data Set; Development; Devices; Drug usage; Effectiveness; Enrollment; Epidemiology; Future; Goals; Health; Health Services Accessibility; Independent Scientist Award; Individual; Interview; K-Series Research Career Programs; Laboratories; Latino; Latino Population; Learning; Life Experience; Link; Literature; Maintenance; Marketing; Measures; Mental disorders; Mentors; Mentorship; Methodology; Methods; Minority; Modeling; Not Hispanic or Latino; Outcome; Parents; Patient Representative; Patients; Population; Program Evaluation; Protocols documentation; Quality of life; Reach Effectiveness Adoption Implementation and Maintenance; Recommendation; Research; Research Design; Research Personnel; Sampling; Scientist; Smoker; Smoking; Socioeconomic Factors; Surveys; Technology Transfer; Testing; Therapeutic Intervention; Therapeutic Uses; Time; Tobacco Control Research; Tobacco Use Disorder; Tobacco use; Training; Translating; Voice; Work; addiction; base; behavioral health; community consultation; cost effectiveness; design; digital; digital intervention; digital treatment; efficacy evaluation; efficacy testing; efficacy trial; ethnic minority; experience; health equity; health inequalities; implementation evaluation; implementation facilitators; implementation science; informant; novel; outreach; population health; pragmatic trial; programs; psychological distress; quitline; racial and ethnic; racial minority; racism; recruit; scale up; severe mental illness; smoking cessation; trial design; user centered design

PROJECT ABSTRACT The goal of this Independent Scientist Award (K02) is to seek five years of training and protected time to enable and expand the work of a newly established independent investigator. The candidate’s laboratory, the Access to Behavioral Health for All (ABHA) Lab, is supported by a recent R01 (Parent Study; DA037276; March 2020-2025) that will evaluate the efficacy of a novel digital therapeutic (DTx) for smoking cessation tailored to patients with serious mental illness. The candidate’s research to date has focused on the development of DTx using user-centered design research, and the subsequent testing of their efficacy using clinical trials methodology. However, efficacy trials do not always translate into real-world practice, nor are tested treatments always adopted by racial and ethnic minorities. This gap is well documented in the implementation science literature. A recent longitudinal epidemiological survey (N=40,181) showed that while the smoking rates of Non-Hispanic Whites with serious psychological distress significantly declined over the last decade, no significant declines occurred among their Black and Latino counterparts. This data accentuates the critical need to develop DTx that have an equitable population health impact. Therefore, the five years of protected time provided by this Independent Scientist Award will fundamentally enhance the candidate’s current program of research by providing formal training and contact with expert collaborators in the following key areas: (1) health equity and participatory research, (2) implementation science, and (3) DTx’s oversight, marketing, and dissemination. The award will also support a convergent mixed-methods Ancillary Study based on the RE-AIM framework, that will examine health equity and implementation science outcomes in the Parent Study. This Independent Scientist Award will provide the necessary research experience and network of collaborators to scale up widespread dissemination of DTx addressing the systemic challenges of racial/ethnic minorities with tobacco use disorder and serious mental illness. Along with the planned collaborations with national experts in each of the key training domains, this award will establish the conditions to pursue and maintain this program of research in the future by protecting the candidate’s time from clinical responsibilities. In the short term, the award will generate preliminary data to inform the design of a large pragmatic trial that will evaluate equitable dissemination of DTx for smoking cessation in patients with serious mental illness. In the long term the award will generate a new body of research rigorously examining racial and ethnic inequities in DTx for addiction treatment, a new model for the equitable implementation and technology transfer of DTx among racial/ethnic minorities, and mentoring opportunities for diverse junior scientists that will extend the impact of this work beyond the candidate’s own program of research.

项目摘要 该独立科学家奖（K02）的目标是寻求五年的培训和受保护的时间 启用并扩大新成立的独立调查员的工作。候选人的实验室， 全民行为健康 (ABHA) 实验室得到最近的 R01（家长研究；DA037276； 2020 年 3 月至 2025 年），将评估新型数字疗法 (DTx) 的戒烟功效 为患有严重精神疾病的患者量身定制。候选人迄今为止的研究重点是 使用以用户为中心的设计研究开发 DTx，并使用以下方法对其功效进行后续测试 临床试验方法。然而，功效试验并不总是转化为现实世界的实践，也不是 少数种族和族裔总是采用经过测试的治疗方法。这种差距在 实施科学文献。最近的一项纵向流行病学调查（N=40,181）表明，虽然 患有严重心理困扰的非西班牙裔白人的吸烟率在过去几年中显着下降 过去十年，黑人和拉丁裔人口的数量没有出现显着下降。这个数据凸显了 迫切需要开发对人口健康具有公平影响的 DTx。因此，这五年 该独立科学家奖提供的受保护时间将从根本上提高候选人的能力 目前的研究计划，通过在以下方面提供正式培训和与专家合作者的联系 关键领域：(1) 健康公平和参与性研究，(2) 实施科学，以及 (3) DTx 的监督， 营销和传播。该奖项还将支持基于聚合混合方法的辅助研究 RE-AIM 框架将审查家长的健康公平性和实施科学成果 学习。该独立科学家奖将提供必要的研究经验和网络 合作者扩大 DTx 的广泛传播，解决种族/民族的系统性挑战 患有烟草使用障碍和严重精神疾病的少数群体。除了计划中的合作之外 每个关键培训领域的国家专家，该奖项将为追求和 通过保护候选人的时间免受临床责任来维持该研究计划。 在短期内，该奖项将产生初步数据，为大型实用试验的设计提供信息 将评估 DTx 在严重精神疾病患者戒烟中的公平传播。在 从长远来看，该奖项将产生一个新的研究机构，严格审视种族和民族不平等 DTx 用于成瘾治疗，DTx 公平实施和技术转让的新模式 少数族裔/族裔之间的合作，以及为不同的初级科学家提供指导机会，这将扩大 这项工作的影响超出了候选人自己的研究计划。