Innovative Smartphone Application for Quitting Smoking among Seriously Mentally III

该独立之路奖（PIA）的长期目标是制定一个研究项目，重点是利用移动健康技术提高患有严重精神疾病（SMI）的成年人戒烟干预的有效性和覆盖面。这一长期目标将通过一项为期5年的培训和研究计划来实现，该计划将启动罗杰·维拉达加博士的独立研究和学术生涯计划。本奖项的职业目标是：(1)成为行为戒烟干预科学方面的专家；(2)掌握流动卫生干预措施的开发、测试和实施；(3)成为实施重度精神障碍患者临床试验的专家。这些职业目标将通过正式课程、培训、研讨会、全国会议、指导和研究经验来实现。从这个培训计划中获得的知识将装备PI追求以下目标。第一个目标是在一个专家小组的指导下，为重度精神障碍患者开发一款接受和承诺治疗智能手机戒烟应用程序，并为员工开发一款智能手机指导指南。第二个目标是在10名重度精神障碍患者的样本中对最终的应用程序和指导指南进行迭代可用性测试。最后，第三个目标是进行一项两组可行性随机试验，将新应用程序与基于最佳戒烟实践指南（QuitGuide）的应用程序进行比较，样本来自社区设置的90名重度精神障碍患者。两组将包括低成本的药理学干预（尼古丁替代疗法）。该试验的主要可行性结果（例如，招募和保留率）将确定进行全动力R01试验的可靠方法。Drs。Richard Ries将担任该PIA的主要导师，为Vilardaga博士接受培训并在新机构中成为独立调查员提供支持。SMI、戒烟、计算机科学和方法/统计方面的专家指导和咨询团队(dr。Ries, McClernon, Ziedonis, Saxon， Kientz和Atkins)将确保PI获得必要的支持，以成功完成拟议的研究。K99将在华盛顿大学和西雅图的弗雷德·哈钦森癌症研究中心举行。00将在杜克大学举行。这些尖端的研究机构将为完成PI的目标提供良好的环境。该研究符合NIDA的主要规划优先事项，即使用创新技术，整合行为和药理学干预，以改善药物使用治疗和结果（NOT-DA-10-019）。这项研究解决了一个严重的问题——重度精神障碍患者的高吸烟率，并提出了一种有希望的行为干预方法，可以在“现实世界”的环境中使用更广泛的技术来戒烟。通过为重度精神分裂症患者戒烟的流动卫生干预工作奠定基础，该项目将为重度精神分裂症患者的独立之路奠定基础。

The long term goal of this Pathway to Independence Award (PIA) is to develop a program of research focused on increasing the effectiveness and reach of smoking cessation interventions for adults with serious mental illness (SMI) using mobile health technology. This long term goal will be achieved via a 5-year training and research plan that will launch Dr. Roger Vilardaga’s independent program of research and academic career. The career objectives of this award are to: (1) become an expert in the science of behavioral smoking cessation interventions; (2) master the development, testing and implementation of mobile health interventions; (3) become an expert in the implementation of clinical trials in people with SMI. These career objectives will be achieved via formal coursework, trainings, seminars, national conferences, mentorship and research experience. The knowledge derived from this training plan will equip the PI to pursue the following aims. The first aim, guided by an expert panel, is to develop an Acceptance and Commitment Therapy smartphone application for smoking cessation for people with SMI, and a smartphone coaching guide for staff. The second aim is to conduct iterative usability testing of the resulting app and coaching guide in a sample of 10 people with SMI. Finally, the third aim is to conduct a two-arm feasibility randomized trial that compares the novel app to an app based on best-practice smoking cessation guidelines (QuitGuide) in a sample of 90 people with SMI from a community-based setting. Both arms will include a low cost pharmacological intervention (nicotine replacement therapy). The primary feasibility outcomes in this trial (e.g., recruitment and retention rates) will determine a reliable methodological approach to conduct a fully-powered R01 trial. Drs. Richard Ries will serve as the primary mentor on this PIA, providing support as Dr. Vilardaga receives his training and establishes himself as an independent investigator in a new institution. The mentoring and consulting team of experts in SMI, smoking cessation, computer science and methods/statistics (Drs. Ries, McClernon, Ziedonis, Saxon, Kientz and Atkins), will ensure that the PI receives the necessary support to successfully complete the proposed research. The K99 will take place at the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle. The R00 will take place at Duke University. These cutting-edge research institutions will provide an excellent environment for completion of the PI’s objectives. This study meets NIDA’s major programmatic priorities of using innovative technologies and integrating behavioral and pharmacological interventions to improve substance use treatment and outcomes (NOT-DA-10-019). The study addresses a serious problem –high smoking rates in people with SMI–, and it proposes the delivery of a promising behavioral intervention for smoking cessation in a “real-world” setting using a wider reaching technology. This PIA will forge the PI’s pathway to independence by laying the foundation for a career in mobile health interventions for smoking cessation in people with SMI.