USC ADRC Diversity Supplement - Guzman

南加州大学 ADRC 多样性补充 - 古兹曼

• 批准号: 10457217
• 负责人: HELENA Chang CHUI
• 金额: $ 5.72万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10457217
• 关键词: Age; Alzheimer' s Disease; Alzheimer’s disease biomarker; Amyloid; Animals; Axon; Basic Science; Biological; Biological Markers; Biology; Blood Vessels; Brain Pathology; Caregivers; Catchment Area; Cells; Cessation of life; Characteristics; Clinical; Clinical Research; Cohort Studies; Complex; Conflict (Psychology); Confounding Factors (Epidemiology); Data; Data Set; Databases; Dementia; Development; Diagnosis; Disease; Enrollment; Evaluation; Fostering; Gene Expression; Genetic; Genetic Transcription; Goals; Gossypium; Health Sciences; Heterogeneity; Hippocampus (Brain); Histologic; Histology; Human; Image; Image Analysis; Individual; Late Onset Alzheimer Disease; Latinx; Latinx population; Magnetic Resonance Imaging; Mentors; Metabolic; Methods; Microglia; Microscopic; Minority; Minority Groups; Modeling; Molecular; Molecular Genetics; Mutation; Neurofibrillary Tangles; Neurons; Neuropil Threads; Participant; Pathogenesis; Pathologic; Play; Positron-Emission Tomography; Postdoctoral Fellow; Prevalence; Process; RNA; RNA analysis; Research; Research Personnel; Resources; Risk Factors; Role; Senile Plaques; Slide; Spastic Paraparesis; Specificity; Standardization; Subgroup; System; Techniques; Temporal Lobe; Therapeutic Intervention; Time; Tissues; Translational Research; Underrepresented Minority; Vascular Diseases; Wool; Work; aging brain; apolipoprotein E-4; autosomal dominant Alzheimer' s disease; brain research; cell type; cohort; data management; diagnostic biomarker; digital imaging; doctoral student; education research; gamma secretase; neuroinflammation; neuron loss; neuropathology; neurotoxic; neurovascular unit; novel diagnostics; outreach; personalized medicine; pre-clinical; presenilin-1; preservation; recruit; research study; specific biomarkers; standard measure; tau Proteins; therapeutically effective; transcriptomics; vascular contributions; whole slide imaging

Abstract The 3 overarching goals of the USC Alzheimer Disease Research Center (ADRC) are to: 1) Elucidate vascular contributions to Alzheimer disease (AD), 2) catalyze basic, clinical, and translational research in AD at USC, and 3) contribute expertise in vascular disease, biomarkers, and imaging to national collaborative initiatives. The ADRC is led by 3 multiple PD/PIs: Chui, Zlokovic, and Toga and comprised of 6 required cores, the required Research Education Component (REC), and 1 optional imaging core. The Administration Core (Chui, Zlokovic, Toga) provides administrative and scientific oversight across USC ADRC, including fostering development projects and supporting ADRC-affiliated studies. The Clinical Core (Schneider, Ringman, Chui) performs standardized evaluations and diagnoses using the NACC Uniform Data Set (UDS), enrolls and follows participants in our 2 primary ADRC cohorts: Vascular Cohort Study (VCS) and Brain Research Study (BRS). The Data Management and Statistical Core (Toga and Chen) oversees the NACC UDS database, provides study- and core-specific databases and curates our large imaging data sets as a local and national resource. The Neuropathology Core (Miller and Hawes) performs standardized neuropathological examinations, stores and distributes biological tissues to research investigators. The Outreach, Recruitment, and Engagement Core (Aranda) works closely with the Clinical Core to recruit and retain the primary ADRC cohort, focusing on under- represented minority groups (especially Latinx), and the development of a participant-caregiver dyad resource database. The Biomarker Core (Zlokovic) uses state of the art methods to determine cell-and system-specific biomarkers related to the neurovascular unit, as well as to measure standard AD biomarkers. The Imaging Core (Toga and Pa) provides high field (3T and 7T) MR imaging, as well as amyloid/tau PET scans. The Research Education Component (Yassine) is dedicated to mentoring post-doctoral students committed to the study of minority issues in Alzheimer disease and related disorders. The USC Health Science Campus is located near high Latinx catchment areas. Treatable vascular-metabolic risk factors (VMRF) are particularly prevalent among the Latinx population and dovetail with the research focus of the USC ADRC.

摘要 南加州大学阿尔茨海默病研究中心（ADRC）的3个首要目标是：1）阐明血管 对阿尔茨海默病（AD）的贡献，2）催化AD的基础，临床和转化研究， 南加州大学，和3）贡献血管疾病，生物标志物和成像的专业知识，以国家合作 举措ADRC由3个多个PD/PI领导：Chui，Zlokovic和Toga，并由6个必需的核心组成， 所需的研究教育组件（REC）和1个可选成像核心。行政核心 (Chui，Zlokovic，Toga）在南加州大学ADRC提供行政和科学监督，包括促进 发展项目和支持ADRC附属研究。临床核心（Schneider，Ringman，Chui） 使用NACC统一数据集（UDS）进行标准化评估和诊断， 我们的2个主要ADRC队列的参与者：血管队列研究（Vascular Cohort Study）和脑研究研究（Brain Research Study）（BRS）。 数据管理和统计核心（Toga和Chen）监督NACC UDS数据库，提供 研究和核心特定的数据库和策展我们的大型成像数据集作为地方和国家资源。 神经病理学核心（米勒和霍伊斯）进行标准化的神经病理学检查，存储 并将生物组织分发给研究人员。外展，招聘和参与核心 （Aranda）与临床核心密切合作，招募和保留主要的ADRC队列，重点是 代表少数群体（特别是拉丁裔），并开发参与者-照顾者二元资源 数据库生物标志物核心（Zlokovic）使用最先进的方法来确定细胞和系统特异性 与神经血管单位相关的生物标志物，以及测量标准AD生物标志物。成像芯 (Toga和Pa）提供高场（3 T和7 T）MR成像以及淀粉样蛋白/tau PET扫描。研究 教育部分（Yassine）致力于指导致力于研究的博士后学生， 阿尔茨海默病及相关疾病中的少数群体问题。南加州大学健康科学校区位于 高拉丁美洲集水区。可治疗的血管代谢危险因素（VMRF）在以下人群中特别普遍： 拉丁裔人口和吻合的研究重点南加州大学ADRC。