USC ADRC Diversity Supplement - Guzman

南加州大学 ADRC 多样性补充 - 古兹曼

• 批准号: 10457217
• 负责人: HELENA Chang CHUI
• 金额: $ 5.72万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10457217
• 关键词: Age; Alzheimer' s Disease; Alzheimer’s disease biomarker; Amyloid; Animals; Axon; Basic Science; Biological; Biological Markers; Biology; Blood Vessels; Brain Pathology; Caregivers; Catchment Area; Cells; Cessation of life; Characteristics; Clinical; Clinical Research; Cohort Studies; Complex; Conflict (Psychology); Confounding Factors (Epidemiology); Data; Data Set; Databases; Dementia; Development; Diagnosis; Disease; Enrollment; Evaluation; Fostering; Gene Expression; Genetic; Genetic Transcription; Goals; Gossypium; Health Sciences; Heterogeneity; Hippocampus (Brain); Histologic; Histology; Human; Image; Image Analysis; Individual; Late Onset Alzheimer Disease; Latinx; Latinx population; Magnetic Resonance Imaging; Mentors; Metabolic; Methods; Microglia; Microscopic; Minority; Minority Groups; Modeling; Molecular; Molecular Genetics; Mutation; Neurofibrillary Tangles; Neurons; Neuropil Threads; Participant; Pathogenesis; Pathologic; Play; Positron-Emission Tomography; Postdoctoral Fellow; Prevalence; Process; RNA; RNA analysis; Research; Research Personnel; Resources; Risk Factors; Role; Senile Plaques; Slide; Spastic Paraparesis; Specificity; Standardization; Subgroup; System; Techniques; Temporal Lobe; Therapeutic Intervention; Time; Tissues; Translational Research; Underrepresented Minority; Vascular Diseases; Wool; Work; aging brain; apolipoprotein E-4; autosomal dominant Alzheimer' s disease; brain research; cell type; cohort; data management; diagnostic biomarker; digital imaging; doctoral student; education research; gamma secretase; neuroinflammation; neuron loss; neuropathology; neurotoxic; neurovascular unit; novel diagnostics; outreach; personalized medicine; pre-clinical; presenilin-1; preservation; recruit; research study; specific biomarkers; standard measure; tau Proteins; therapeutically effective; transcriptomics; vascular contributions; whole slide imaging

Abstract The 3 overarching goals of the USC Alzheimer Disease Research Center (ADRC) are to: 1) Elucidate vascular contributions to Alzheimer disease (AD), 2) catalyze basic, clinical, and translational research in AD at USC, and 3) contribute expertise in vascular disease, biomarkers, and imaging to national collaborative initiatives. The ADRC is led by 3 multiple PD/PIs: Chui, Zlokovic, and Toga and comprised of 6 required cores, the required Research Education Component (REC), and 1 optional imaging core. The Administration Core (Chui, Zlokovic, Toga) provides administrative and scientific oversight across USC ADRC, including fostering development projects and supporting ADRC-affiliated studies. The Clinical Core (Schneider, Ringman, Chui) performs standardized evaluations and diagnoses using the NACC Uniform Data Set (UDS), enrolls and follows participants in our 2 primary ADRC cohorts: Vascular Cohort Study (VCS) and Brain Research Study (BRS). The Data Management and Statistical Core (Toga and Chen) oversees the NACC UDS database, provides study- and core-specific databases and curates our large imaging data sets as a local and national resource. The Neuropathology Core (Miller and Hawes) performs standardized neuropathological examinations, stores and distributes biological tissues to research investigators. The Outreach, Recruitment, and Engagement Core (Aranda) works closely with the Clinical Core to recruit and retain the primary ADRC cohort, focusing on under- represented minority groups (especially Latinx), and the development of a participant-caregiver dyad resource database. The Biomarker Core (Zlokovic) uses state of the art methods to determine cell-and system-specific biomarkers related to the neurovascular unit, as well as to measure standard AD biomarkers. The Imaging Core (Toga and Pa) provides high field (3T and 7T) MR imaging, as well as amyloid/tau PET scans. The Research Education Component (Yassine) is dedicated to mentoring post-doctoral students committed to the study of minority issues in Alzheimer disease and related disorders. The USC Health Science Campus is located near high Latinx catchment areas. Treatable vascular-metabolic risk factors (VMRF) are particularly prevalent among the Latinx population and dovetail with the research focus of the USC ADRC.

摘要 南加州大学阿尔茨海默病研究中心(ADRC)的3个首要目标是：1)阐明血管 对阿尔茨海默病(AD)的贡献，2)催化AD的基础、临床和翻译研究，请访问 南加州大学，以及3)为国家协作贡献血管疾病、生物标记物和成像方面的专业知识 首创精神。ADRC由3个多PD/PI领导：Chui、Zlokovic和Toga，并由6个必需的核心组成， 必需的研究教育组件(REC)和1个可选的成像核心。管理核心 (Chui、Zlokovic、Toga)在整个南加州大学ADRC提供行政和科学监督，包括促进 发展项目和支持与发展中心有关的研究。临床核心(施耐德、林曼、崔) 使用NACC统一数据集(UDS)执行标准化评估和诊断、登记和跟踪 我们的两个主要ADRC队列的参与者：血管队列研究(VCS)和脑研究(BRS)。 数据管理和统计核心(Toga和Chen)监督NACC UDS数据库，提供 研究和核心特定的数据库，并将我们的大型成像数据集作为地方和国家资源进行管理。 神经病理核心(Miller和Hawes)执行标准化的神经病理检查，商店 并将生物组织分发给研究人员。拓展、招聘和参与的核心 (Aranda)与临床核心密切合作，招募和保留主要的ADRC队列，重点放在以下方面： 代表少数群体(特别是拉丁裔)，以及参与者-照顾者二元资源的开发 数据库。Biomarker Core(Zlokovic)使用最先进的方法确定特定于细胞和系统的 与神经血管单位相关的生物标记物，以及测量标准AD生物标记物。影像核心 (toga和pa)提供高场(3T和7T)MR成像，以及淀粉样蛋白/tau PET扫描。研究报告 教育部分(Yassine)致力于指导致力于研究 阿尔茨海默病及相关疾病中的少数群体问题。南加州大学健康科学校区位于 拉美裔人口聚集区。可治疗的血管代谢危险因素(VMRF)在 拉丁裔人口和与南加州大学ADRC的研究重点相吻合。